6533b837fe1ef96bd12a270d

RESEARCH PRODUCT

Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry

Christiano ArganoNicola ScichiloneGiuseppe NatoliNobili AlessandroGino Roberto CorazzaPier Mannuccio MannucciFrancesco PerticoneCorrao SalvatorePier Mannuccio MannucciAlessandro NobiliAntonello PietrangeloGiuseppe LicataFrancesco VioliGino Roberto CorazzaSalvatore CorraoMarengoni AlessandraFrancesco SalernoMatteo CesariMauro TettamantiLuca PasinaCarlotta FranchiGabriella MiglioLaura CortesiIlaria ArdoinoAlessio NovellaDomenico PriscoElena SilvestriGiacomo EmmiAlessandra BettiolCenci CaterinaGianni BioloMichela ZanettiMartina GuadagniMichele ZaccariMassimiliano ChiuchMichele ZaccariMassimo VanoliGiulia GrignaniEdoardo Alessandro PulixiMauro BernardiSilvia Li BassiLuca SantiGiacomo ZaccheriniGraziana LupattelliElmo MannarinoVanessa BianconiFrancesco PaciulloRiccardo AlcidiRanuccio NutiRoberto ValentiMartina RuvioSilvia CappelliAlberto PalazzuoliDomenico GirelliFabiana BustiGiacomo MarchiMario BarbagalloLigia DominguezFloriana CocitaVincenza BeneduceLidia PlancesSalvatore CorraoGiuseppe NatoliSalvatore MularoMassimo RaspantiFederica CavallaroMarco ZoliIlaria LazzariMattia BrunoriElisa FabbriDonatella MagalottiRaffaella ArnòFranco Laghi PasiniPier Leopoldo CapecchiGiuseppe PalascianoMaria Ester ModeoCarla Di GennaroMaria Domenica CappelliniDiletta MairaValeria Di StefanoGiovanna FabioSonia SeghezziMarta MancarellaMargherita Migone De AmicisGiacomo De LucaNatalia ScaramelliniMatteo CesariPaolo Dionigi RossiSarah DamantiMarta ClericiFederica ContiGiulia BoniniBarbara Brignolo OttoliniAntonio Di SabatinoEmanuela MiceliMarco Vincenzo LentiMartina PisatiCostanza Caccia DominioniGiovanni MurialdoAlessio MarraFederico CattaneoRoberto PontremoliValentina BeccatiGiulia NobiliMaria Beatrice SecchiDavide GhelfiLuigi AnastasioLucia SofiaMaria CarboneFrancesco CipolloneMaria Teresa GuagnanoEmanuele ValerianiIlaria RossiGerardo MancusoDaniela CalipariMosè BartoneGiuseppe DelitalaMaria BerriaChiara PesAlessandro DelitalaMaurizio MuscaritoliAlessio MolfinoEnrico PetrilloGiuseppe ZuccalàGabriella D’aurizioGiuseppe RomanelliAlessandra MarengoniAlberto ZucchelliFrancesca ManzoniAndrea VolpiniAntonio PicardiUmberto Vespasiani GentilucciPaolo GalloChiara Dell’untoGiorgio AnnoniMaurizio CorsiGiuseppe BellelliSara ZazzettaPaolo MazzolaHajnalka SzaboAlessandra BonfantiFranco ArturiElena SuccurroMariangela RubinoBruno TassoneGiorgio SestiMaria Grazia SerraMaria Antonietta BleveLaura GasbarroneMaria Rosaria SajevaAntonio BrucatoSilvia GhidoniFabrizio FabrisIrene BertozziGiulia BogoniMaria Victoria RabuiniElisabetta CosiPaolo ScarinziAnnalisa AmabileElisabetta OmenettoTancredi PrandiniRoberto ManfrediniFabio FabbianBenedetta BoariAlfredo De GiorgiRuana TiseoRoberto De GiorgioGiuseppe PaolissoMaria Rosaria RizzoClaudio BorghiEnrico StrocchiEugenia IannielloMario SoldatiCarlo SabbàFrancesco Saverio VellaPatrizia SuppressaAndrea SchilardiFrancesca LoparcoGiovanni Michele De VincenzoAlessio ComitangeloEmanuele AmorusoLuigi FenoglioAndrea FalcettaChristian BraccoAnna L. Fracanzani Silvia FargionSilvia TiraboschiAnnalisa CespiatiGiovanna ObertiGiordano SigonFlora PeyvandiRaffaella RossioBarbara FerrariGiulia ColomboPasquale AgostiValter MonzaniValeria SavojardoChristian FolliGiuliana CerianiFrancesco SalernoGiada PalliniFranco DallegriLuciano OttonelloLuca LiberaleLara CaserzaKassem SalamNicola Lucio LiberatoTiziana TogninGiovanni Battista BianchiSabrina GiaquintoFrancesco PurrelloAntonino Di PinoSalvatore PiroRenzo RozziniLina FalangaElena SpazziniCamillo FerrandinaGiuseppe MontrucchioPaolo PetittiPaolo PeassoEdoardo FavaleCesare PolettoRaffaella SalmiPiergiorgio GaudenziFrancesco VioliLudovica PerriRaffaele LandolfiMassimo MontaltoAntonio MirijelloLuigina GuastiLuana CastiglioniAndrea MarescaAlessandro SquizzatoLeonardo CampiottiAlessandra GrossiMarco BertolottiChiara MussiGiulia LancellottiMaria Vittoria LibbraGiulia DondiElisa PellegriniLucia CarulliMatteo GalassiYasmine GrassiFrancesco PerticoneMaria PerticoneRosa BattagliaMarco FiliceRaffaele MaioVincenzo StanghelliniEugenio RuggeriSara Del VecchioAndrea SalviRoberto LeonardiGiampaolo DamianiWilliam CapeciArmando GabrielliMassimo MattioliGiuseppe Pio MartinoLorenzo BiondiPietro PettinariRiccardo GhioAnna Dal ColSalvatore MinisolaLuciano ColangeloMirella CilliGiancarlo LabbadiaAntonella AfeltraBenedetta MariglianoMaria Elena PipitaPietro CastellinoLuca ZanoliSamuele PignataroAlfio GennaroJulien BlancoValter SaraccoMarisa FogliatiCarlo BussolinoFrancesca MeteMiriam GinoAntonio CittadiniCarlo VigoritoMichele ArcopintoAndrea SalzanoEmanuele BobbioAlberto M. MarraSirico DomenicoGuido MoreoFrancesca GaspariniSilvia ProloGloria PinaAlberto BallestreroFabio FerrandoSergio BerraSimonetta DassiMaria Cristina NavaBruno GraziellaStefano BaldassarreSalvatore FragapaniGabriella GrudenGiorgio GalantiGabriele MascheriniCristian PetriLaura StefaniMargherita GirinoValeria PiccinelliFrancesco NassoVincenza GioffrèMaria PasqualeGiuseppe ScattolinSergio MartinelliMauro TurrinLeonardo SechiCristina CatenaGianluca ColussiNicola PassarielloLuca RinaldiFranco BertiGiuseppe FamularoPatrizia TarsitaniRoberto CastelloMichela PasinoGian Paolo CedaMarcello Giuseppe MaggioSimonetta MorgantiAndrea ArtoniStefano Del GiaccoDavide FirinuFrancesca LosaGiovanni PaolettiGiulia CostanzoGiuseppe MontaltoAnna LicataValentina MalerbaFilippo Alessandro MontaltoAntonino LascoGiorgio BasileAntonino CatalanoLorenzo MalatinoBenedetta StancanelliValentina TerranovaSalvatore Di MarcaRosario Di QuattroLara La MalfaRossella CarusoPatrizia MecocciCarmelinda RuggieroVirginia BoccardiTiziana MeschiFulvio LauretaniAndrea TicinesiAntonio NouvennePietro MinuzLuigi FondrieschiMario PirisiGian Paolo FraDaniele SolaMassimo PortaPiero RivaRoberto QuadriErica LarovereMarco NovelliGiorgio ScanziCaterina MengoliStella ProviniLaura RicevutiEmilio SimeoneRosa ScurtiFabio TollosoRoberto TarquiniAlice ValorianiSilvia DolentiGiulia VanniniAlberto TedeschiLucia TrottaRiccardo VolpiPietro BocchiAlessandro VignaliSergio HarariChiara LonatiMara CattaneoFederico Napoli

subject

Malemedicine.medical_specialtyChronic ObstructiveCirrhosisSocio-culturaleComorbidity030204 cardiovascular system & hematologycomorbiditieselderlyPulmonary Disease03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineInternal medicinemedicine80 and overCOPDHumans030212 general & internal medicineLS4_4RegistriesHospital MortalityCOPD comorbidities elderly internal medicine in-hospital mortality.Depression (differential diagnoses)Cause of deathAgedRetrospective Studies1-year mortality; 3-month mortality; COPD; comorbidities; elderly; internal medicine; in-hospital mortalityAged 80 and overCOPDbusiness.industry1-year mortality; 3-month mortality; COPD comorbidities elderly internal medicine in-hospital mortalitymedicine.diseaseIm - Original1-year mortality; 3-month mortality; COPD comorbidities elderly internal medicine in-hospital mortality; Aged; Aged 80 and over; Comorbidity; Female; Humans; Internal Medicine; Male; Pulmonary Disease Chronic Obstructive; Registries; Retrospective Studies; Hospital Mortalityinternal medicineClinical diagnosisCohortEmergency Medicine1-year mortality3-month mortalityCOPD comorbidities elderly internal medicine in-hospital mortality1-year mortality 3-month mortality COPD comorbidities elderly internal medicine in-hospital mortality.Observational studyFemalebusiness1 year mortalityin-hospital mortality

description

Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards. Electronic supplementary material The online version of this article (10.1007/s11739-020-02412-1) contains supplementary material, which is available to authorized users.

yearjournalcountryeditionlanguage
2020-07-27
10.1007/s11739-020-02412-1http://hdl.handle.net/11591/436885