Search results for " Competitive"
showing 10 items of 237 documents
Distribution of chlorpromazine in a simplified blood influenced by various drugs
1973
The binding of chlorpromazine to erythrocytes and to albumin as influenced by other drugs was studied in a simplified blood (31.5±0.3% bovine erythrocytes, 4 g-% bovine serum albumin in 0.02 M phosphate buffer solution containing 0.15 M NaCl). the total concentration of chlorpromazine in the simplified blood was 10−4 M, the concentration of the displacing drugs was 10−3 M. After an incubation period of 3 h at 22° C the chlorpromazine concentration was determined in the albumin solution after centrifugation of the blood at 3000×g and in the aqueous phase after ultracentrifugation at 150000×g. Under control conditions 68.1±0.9% of chlorpromazine was bound to the erythrocytes, 28.5±0.9% was bo…
The atractiveness and competitiveness of tourist destinations: A study on Southern Italian regions
2009
The present paper aims to assess the relative attractiveness of competing tourist destinations on the basis of individual visitors' perceptions regarding a holiday destination. Using the feeling of tourist well-being achieved by individual tourists we evaluate indirectly the competitive ability of the tourist area to offer a compound tourist site attractiveness. The methodology employed here uses individual survey questionnaires on the tourists' evaluation of the quality of tourist facilities and attributes in a given area (the 'regional tourist profile') as the basis for constructing an aggregate expression for the relative attractiveness of that area. Using various multidimensional statis…
The economic impact of the EFF on the competitiveness of Sicilian fish companies
2017
The measure 2.3 of the European Fisheries Fund, in Sicily, claimed investments of fish companies in production capacity expansion and modernization of fish processing. Have these investments been effective in supporting the competitiveness of these companies and have they influenced the economic sustainability of the regional seafood chain? Proposed analysis contributes to this assessment through an exploratory survey and a review of the changes in their business performance.
Faktori, kas ietekmē Latvijas loģistikas uzņēmumu konkurētspēju ES
2019
Promocijas darbā tiek pētīta Latvijas loģistikas uzņēmumu konkurētspēja. Loģistika ir viena no galvenajām Latvijas nozarēm. Tāpēc ir svarīgi pievērsties galvenās nozares uzlabošanai. Tomēr konkurence nav balstīta uz vienu faktoru; būs vairāki faktori, kas ietekmē konkurētspēju. Promocijas darbā tiek pētīti Latvijas loģistikas uzņēmumu konkurētspēju ietekmējošie faktori. Konkurence Eiropas Savienībā ir tik spēcīga, tāpēc ir svarīgi koncentrēties uz Latvijas loģistikas uzņēmumu konkurētspēju, lai uzlabotu produktivitāti un peļņu. Loģistikas nozares sarežģītība arī padara to par būtisku to izpētei. Tā kā loģistikas nozare ir atkarīga no vairākiem faktoriem, promocijas darbā tiek analizēti četr…
Sicilian floriculture companies and the role of transport in increasing their competitiveness
2008
The aim of this study is to provide a deeper understanding of the Sicilian floriculture sector, which has recently become one of the most important on a regional and national scale. By analysing production, sales and logistical aspects of its production companies and specifically looking at aspects regarding transport logistics, this study highlights the sector operators. preference for road transport that offers better guarantees in terms of delivery speed with respect to other means of transport, an essential requirement for the transport of flowers and plants. However, operators are increasingly showing interest in alternative means of transport that may reduce transport time and, especi…
SYNTHESIS AND IN VITRO AFFINITIES OF VARIOUS MDL 100907 DERIVATIVES AS POTENTIAL 18F-RADIOLIGANDS FOR 5-HT2A RECEPTOR IMAGING WITH PET
2008
Radiolabelled piperidine derivatives such as [(11)C]MDL 100907 and [(18)F]altanserin have played an important role in diagnosing malfunction in the serotonergic neurotransmission. A variety of novel piperidine MDL 100907 derivatives, possible to label with (18)F-fluorine, were synthesized to improve molecular imaging properties of [(11)C]MDL 100907. Their in vitro affinities to a broad spectrum of neuroreceptors and their lipophilicities were determined and compared to the clinically used reference compounds MDL 100907 and altanserin. The novel compounds MA-1 (53) and (R)-MH.MZ (56) show K(i)-values in the nanomolar range towards the 5-HT(2A) receptor and insignificant binding to other 5-HT…
Total synthesis and evaluation of [18F]MHMZ.
2007
Radiochemical labeling of MDL 105725 using the secondary labeling precursor 2-[(18)F]fluoroethyltosylate ([(18)F]FETos) was carried out in yields of approximately 90% synthesizing [(18)F]MHMZ in a specific activity of approximately 50MBq/nmol with a starting activity of approximately 3GBq. Overall radiochemical yield including [(18)F]FETos synthon synthesis, [(18)F]fluoroalkylation and preparing the injectable [(18)F]MHMZ solution was 42% within a synthesis time of approximately 100 min. The novel compound showed excellent specific binding to the 5-HT(2A) receptor (K(i)=9.0 nM) in vitro and promising in vivo characteristics.
RNA-binding activity of the rat calmodulin-binding PEP-19 protein and of the long PEP-19 isoform
2012
Synthesis of H1˚ histone protein, in the developing rat brain, seems to be regulated mainly at the post-transcriptional level. Since regulation of RNA metabolism depends on a series of RNA-binding proteins, we have been searching for RNA-binding proteins involved in the post-transcriptional regulation of the H1˚ gene. We recently reported isolation, from a cDNA expression library, of an insert encoding a novel protein, the C-terminal half of which is identical to that of PEP-19, a brain-specific protein involved in calcium metabolism. The novel protein was called long PEP-19 isoform (LPI). Herein we show that LPI, as well as PEP-19, can bind H1˚ RNA. Moreover, in order to improve production…
Emerging Economies’ Institutional Quality and International Competitiveness: A PLS-SEM Approach
2021
The home country’s institutional framework determines the capacity to compete in the global arena. This paper discusses the linkage between institutional quality (IQ) and international competitiveness (IC). We measured institutions’ quality in emerging economies through the use of selected indicators between 2007–2017. To evaluate the proposed IQ constructs and their relationship with IC, we applied partial least squares – structural equation modeling (PLS-SEM) analysis. The model outcomes suggest that political and lack of systemic conditions have a significant and negative effect on international competitiveness, while science, technology, engineering and mathematics (STEM) resource condi…
Zebrafish Reveals Different and Conserved Features of Vertebrate Neuroglobin Gene Structure, Expression Pattern, and Ligand Binding
2004
Neuroglobin has been identified as a respiratory protein that is primarily expressed in the mammalian nervous system. Here we present the first detailed analysis of neuroglobin from a non-mammalian vertebrate, the zebrafish Danio rerio. The zebrafish neuroglobin gene reveals a mammalian-type exon-intron pattern in the coding region (B12.2, E11.0, and G7.0), plus an additional 5'-non-coding exon. Similar to the mammalian neuroglobin, the zebrafish protein displays a hexacoordinate deoxy-binding scheme. Flash photolysis kinetics show the competitive binding on the millisecond timescale of external ligands and the distal histidine, resulting in an oxygen affinity of 1 torr. Western blotting, i…