Search results for " Continent"
showing 10 items of 182 documents
The influence of socio-economic and surveillance characteristics on breast cancer survival: a French population-based study.
2008
International audience; Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the endpoint. The Cox regression model was used for multivariate analysis. County of residence, age group, occupational status, mammographic surveillance, gynaecological prevention consultations and the diagnosis mammography, whether within a screening framework or not, were independent prognostic factors of survival. Moreover, for the same age group, and on…
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
2011
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may p…
The Ventian mammal age (Latest Miocene): present state
2013
[EN] The Ventian land mammal age includes most of the Spanish faunas assigned to the biochronologic unit MN 13. It is correlatable with the Messinian, although it may include, in its latest part, Early Pliocene faunas. We propose that the Ventian begins with the fi rst occurrence of the Muridae genus Stephanomys (7 Ma, paleomagnetic dating from El Bunker, Teruel basin), well recorded in Teruel basin, and ends with the appearance of Promimomys (ca. 5 Ma), also registered in the Teruel basin. We suggest a new reorganization of the Ventian. The first subdivision corresponds to the zone M (Dam et al., 2001). The second, zone N, is proposed here for the first time, being equivalent to the zone w…
Ten millennia of hepatitis B virus evolution
2021
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd…
Italian familial defective apolipoprotein B patients share a unique haplotype with other Caucasian patients.
2001
Familial defective apolipoprotein (apo) B-100 together with familial hypercholesterolemia are the two common genetic conditions that cause hypercholesterolemia. Familial defective apolipoprotein B-100 is due to mutations around codon 3500 of the apo B gene. The most-characterized mutation is a G>A transition at nucleotide 10,708 that results in the substitution of arginine by glutamine at codon 3500 (Apo B Arg3500Gln). Two other mutations are caused by a C>T transition, one at nucleotide 10,800 (Apo B Arg3531Cys) and the other at nucleotide 10,707 (apo B Arg3500Trp). In the present study we describe three new Italian cases of familial defective apolipoprotein B-100 (Apo B Arg3500Gln), one f…
Quality of life in women undergoing urinary diversion for bladder cancer: results of a multicenter study among long-term disease-free survivors
2012
Purpose: Women undergoing radical cystectomy (RC) and urinary diversion for bladder cancer experience substantial limitations in health-related quality of life (HRQOL). However, the level of discomfort caused by different urinary diversion has been never evaluated in long term survivors. The aim of this multicenter study is to evaluate differences in HRQOL among recurrence-free women undergoing cutaneous ureterostomy (CUS), Bricker's ileal conduit (BK-IC) and Orthotopic neobladder VIP (ONB-VIP) in disease-free females treated with radical cystectomy (RC), with long-term follow up (mean 60.1 months; range 36-122 months). Materials and methods: All consecutively treated female patients from t…
Changes in climatic signals of English oak tree-ring width and cross-section area of earlywood vessels in Latvia during the period 1900–2009
2012
Abstract We investigated changes in response of wood formation in English oak (Quercus robur L.) to climatic factors since 1900. It was hypothesised that the effect of winter and spring temperatures has weakened, while summer precipitation has become limiting. Increment cores were taken from 40 sites across Latvia. Tree-ring width and cross-section area of earlywood vessels were measured and cross-dated. Regional chronologies were built by pooling time series of trees within two regions of Latvia (western and eastern region), which differed in continentality. Climatic signals differed between the proxies (tree-ring width and earlywood vessel cross-section area) and between regions. Mean cro…
Pediatric Urinary Diversion: Review and Own Experience
1992
New insights into the diseases of childhood, profound improvements and new developments in surgical techniques as well as the knowledge gained from long-term follow-up have altered the strategies and indications for urinary diversion in childhood. Continent urinary diversion is generally the method of choice. We are able to construct high capacity, low pressure reservoirs to protect the upper urinary tract and achieve continence. Nowadays, there is hardly any indication for permanent cutaneous urinary diversion. Temporary and intermediate cutaneous diversion are used only when serious conditions such as renal function deterioration occur. The possibility to convert any incontinent form of u…
Tectono-stratigraphic modelling of the North Sicily continental margin (southern Tyrrhenian Sea).
2004
A two-dimensional numerical modelling that simulate the kinematic and thermal response of the lithosphere to thinning was used for the quantitative reconstruction of the late Neogene to Recent times tectonic and stratigraphic evolution of the North Sicily continental margin (southern Tyrrhenian Sea). The numerical study of the evolution of the North Sicily margin builds on the crustal image and kinematic interpretation of the margin obtained by Pepe et al. [Tectonics 19 (2000) 241] on the basis of seismic data and gravity modelling. Tectonic modeling indicate that different segments of the margin were undergoing different vertical movements, which are mainly expression of the rifting and th…
Gathering different marine geology data (seismics, acoustics, sedimentological) to investigate active fluid seepage (AFS) in the southern region of t…
2017
Active Fluid Seepage (AFS) at the seafloor is a global phenomenon associated with seafloor morphologies in different geodynamic contexts. Advances geophysical techniques have allowed geoscientists to characterise pockmarks, mounds and flares associated with AFS. We present a range of marine geological data acquired in the central Mediterranean Sea (northern Sicily continental margin, northwestern Sicily Channel and offshore the Maltese Islands), which allow us to identify AFSs. The AFSs are spatially distributed as clusters, aligned or isolated at different depths, ranging from few decametres offshore the Maltese Islands, up to 400 m offshore north Sicily and in the northwestern Sicily chan…