Search results for " Coronary Artery Disease"

showing 10 items of 49 documents

Polyvascular subclinical atherosclerosis in familial hypercholesterolemia: The role of cholesterol burden and gender

2019

International audience; BACKGROUND AND AIM:Heterozygous familial hypercholesterolemia (HeFH) is a genetic disease characterized by a heterogeneous phenotype. The assessment of cardiovascular (CV) risk is challenging for HeFH. Cholesterol burden (CB) allows to estimate the lifelong exposure to high levels of cholesterol. The aim of this study was to analyze the distribution of subclinical atherosclerosis and the relationship between atherosclerosis and the CB in a sample of HeFH patients, focusing on sex-related differences.METHODS AND RESULTS:154 asymptomatic HeFH subjects underwent coronary-artery-calcium score (CACs) and Doppler ultrasound of carotid and femoral arteries. Yearly lipid pro…

Carotid Artery DiseasesMaleCarotid atherosclerosisPeripheral arterial atherosclerosisTime Factors[SDV]Life Sciences [q-bio]Endocrinology Diabetes and MetabolismMedicine (miscellaneous)Coronary Artery DiseaseDiseaseFamilial hypercholesterolemia030204 cardiovascular system & hematologySeverity of Illness Indexchemistry.chemical_compound0302 clinical medicineRisk FactorsAtherosclerosis; Calcium score; Cardiovascular disease; Cardiovascular risk; Cholesterol burden; Coronary artery calcium; Familial hypercholesterolemia; Peripheral arterial atherosclerosis; Adult; Aged; Asymptomatic Diseases; Biomarkers; Carotid Artery Diseases; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Female; Femoral Artery; Genetic Predisposition to Disease; Humans; Hyperlipoproteinemia Type II; Male; Middle Aged; Paris; Peripheral Arterial Disease; Phenotype; Prevalence; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Sex Factors; Time Factors; Young AdultPrevalenceMedicineNutrition and Dietetics[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismMiddle AgedPrognosisCardiovascular diseaseCalcium score3. Good healthFemoral ArteryCholesterol burdenCholesterolPhenotypeAtherosclerosiCardiologyPopulation studyFemalemedicine.symptomCardiology and Cardiovascular MedicineAdultParismedicine.medical_specialtyFamilial hypercholesterolemia030209 endocrinology & metabolismRisk AssessmentAsymptomaticCoronary artery calciumHigh cholesterolHyperlipoproteinemia Type IIPeripheral Arterial DiseaseYoung Adult03 medical and health sciencesSex Factors[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineHumansGenetic Predisposition to DiseaseAgedbusiness.industryCholesterolAtherosclerosismedicine.diseaseCardiovascular riskCross-Sectional StudieschemistrySubclinical atherosclerosisAsymptomatic DiseasesbusinessBiomarkers
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Prognostic value of clinical routine multislice computed tomography coronary angiography in patient with suspected or known coronary artery disease: …

2009

Comuted Tomography coronary angiography coronary artery disease
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Italian multicenter, prospective study to evaluate the negative predictive value of 16- and 64-slice MDCT imaging in patients scheduled for coronary …

2009

This was a prospective, multicenter study designed to evaluate the utility of MDCT in the diagnosis of coronary artery disease (CAD) in patients scheduled for elective coronary angiography (CA) using different MDCT systems from different manufacturers. Twenty national sites prospectively enrolled 367 patients between July 2004 and June 2006. Computed tomography (CT) was performed using a standardized/optimized scan protocol for each type of MDCT system (> or =16 slices) and compared with quantitative CA performed within 2 weeks of MDCT. A total of 284 patients (81%) were studied by 16-slice MDCT systems, while 66 patients (19%) by 64-slice MDCT scanners. The primary analysis was on-site/off…

Coronary angiographyAdultDiagnostic ImagingMalemedicine.medical_specialtyCoronary Artery DiseaseCoronary Angiographydiagnosis/radiographyCoronary artery diseasemethodsCoronary artery disease16- and 64-slice MDCT imaging coronary angiographySettore MED/36 - Diagnostica per Immagini e RadioterapiaPredictive Value of TestsCoronary Angiography/*methods Coronary Artery Disease/*diagnosis/*radiography Diagnostic Imaging/methods80 and overCardiac CTMedicineHumansRadiology Nuclear Medicine and imagingIn patientcardiovascular diseasesProspective StudiesProspective cohort studyTomographyNeuroradiologyAgedAged 80 and overmedicine.diagnostic_testbusiness.industryMultidetector CTNon invasiveReproducibility of ResultsInterventional radiologyGeneral MedicineAdult Aged Aged; 80 and over Coronary Angiography; methods Coronary Artery Disease; diagnosis/radiography Diagnostic Imaging; methods Female Humans Italy Male Middle Aged Predictive Value of Tests Prospective Studies Reproducibility of Results Tomography; X-Ray Computed; methodsMiddle Agedmedicine.diseasePredictive valueSettore MED/11 - Malattie Dell'Apparato CardiovascolareX-Ray Computedcoronary angiographyCTCardiac CT; Coronary artery disease; Multidetector CTItalyFemaleRadiologycoronary angiographybusinessTomography X-Ray Computed
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Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): a multicen…

2013

PURPOSE: This study was done to assess the prognostic value of computed tomography coronary angiography (CTCA) in a large multicentre population of patients with suspected coronary artery disease (CAD) and, in particular, its incremental value compared with traditional methods for risk stratification. MATERIALS AND METHODS: This is a retrospective observational study that began in January 2003 conducted on patients with suspected CAD assessed with CTCA on the basis of symptoms (chest pain, dyspnoea) and/or abnormal or equivocal stress test and/or a high cardiovascular risk profile. The participating centres will provide data obtained with CTCA performed with 16-slice or higher equipment. Ex…

Coronary angiographyMaleContrast MediaComputed tomographyCoronary DiseaseCoronary AngiographyCoronary artery diseaseComputed tomography coronary angiographyCoronary artery diseaseComputer-AssistedRisk FactorsRegistriesTomographyNeuroradiologyeducation.field_of_studymedicine.diagnostic_testcomputed tomography coronary angiography; coronary artery disease; prevalence of disease; prognosis; registry; risk stratificationRadiographic Image InterpretationInterventional radiologyGeneral MedicineMiddle AgedPrognosisX-Ray ComputedResearch DesignRisk stratificationCardiologyPrevalence of diseaseRadiographic Image Interpretation Computer-AssistedFemaleRadiologymedicine.medical_specialtyRegistryPrognosiEndpoint DeterminationPopulationRisk AssessmentComputed tomography coronary angiography; Coronary artery disease; Prevalence of disease; Prognosis; Risk stratification; Registry; Analysis of Variance; Contrast Media; Coronary Disease; Endpoint Determination; Female; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Radiographic Image Interpretation Computer-Assisted; Retrospective Studies; Risk Assessment; Risk Factors; Coronary Angiography; Registries; Research Design; Tomography X-Ray ComputedInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingeducationRisk stratificationProportional Hazards ModelsRetrospective StudiesAnalysis of Variancebusiness.industrymedicine.diseasebusinessTomography X-Ray ComputedLa Radiologia medica
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Low dose CT of the heart: a quantum leap into a new era of cardiovascular imaging.

2010

In 10 years, computed tomography coronary angiography (CTCA) has shifted from an investigational tool to clinical reality. Even though CT technologies are very advanced and widely available, a large body of evidence supporting the clinical role of CTCA is missing. The reason is that the speed of technological development has outpaced the ability of the scientific community to demonstrate the clinical utility of the technique. In addition, with each new CT generation, there is a further broadening of actual and potential applications. In this review we examine the state of the art on CTCA. In particular, we focus on issues concerning technological development, radiation dose, implementation,…

Coronary angiographymedicine.medical_specialtyCardiologyComputed tomographycardiac CTCoronary DiseaseCoronary AngiographyRadiation DosageCoronary artery diseaseComputed tomography coronary angiographyCoronary artery diseasemedicineTrainingLow dose ctHumansRadiology Nuclear Medicine and imagingMedical physicsNeuroradiologymedicine.diagnostic_testEquipment Safetybusiness.industryRadiation doseRadiation doseGeneral MedicineConventional coronary angiographymedicine.diseaseComputed tomography coronary angiography Conventional coronary angiography Coronary artery disease Radiation dose TrainingClinical realitySafety EquipmentbusinessSettore MED/36 - Diagnostica Per Immagini E RadioterapiaRadiologyTomography X-Ray ComputedLa Radiologia medica
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SYNTAX score is associated with in-hospital mortality as assessed by GRACE risk score in patients with acute myocardial infarction

2013

Coronary angiographymedicine.medical_specialtyFramingham Risk ScoreIn hospital mortalitybusiness.industryCoronary arteriosclerosisHospital mortalitymedicine.diseaseInternal medicineMedicineIn patientMyocardial infarctionMedical emergencyCardiology and Cardiovascular MedicineMulti vessel coronary artery diseasebusinessEuropean Heart Journal
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Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in…

2021

Abstract Background There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clini…

Coronary artery abnormalities; Hypotension; Kawasaki disease; Multisystem inflammatory syndrome associated with coronavirus disease; Myocarditis; Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection; SARS-CoV-2; Age Distribution; Antirheumatic Agents; Aspirin; C-Reactive Protein; COVID-19; Child; Child Preschool; Coronary Artery Disease; Cough; Diarrhea; Dyspnea; Female; Glucocorticoids; Heart Failure; Humans; Hyperferritinemia; Hypotension; Immunoglobulins Intravenous; Immunologic Factors; Infant; Intensive Care Units Pediatric; Interleukin 1 Receptor Antagonist Protein; Italy; Lymphopenia; Male; Mucocutaneous Lymph Node Syndrome; Myocarditis; Platelet Aggregation Inhibitors; SARS-CoV-2; Shock; Systemic Inflammatory Response Syndrome; Tachypnea; Troponin T; VomitingMalelcsh:Diseases of the musculoskeletal systemcoronary artery abnormalities; hypotension; kawasaki disease; multisystem inflammatory syndrome associated with coronavirus disease; myocarditis; pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection; SARS-CoV-2; age distribution; antirheumatic agents; aspirin; C-reactive protein; COVID-19; child ; preschool; coronary artery disease; cough; diarrhea; yspnea; female; glucocorticoids; heart failure; humans; hyperferritinemia; hypotension; immunoglobulins; intravenous; immunologic factors; infant; intensive care units; pediatric; interleukin 1 receptor antagonist protein; italy; lymphopenia; male; mucocutaneous lymph node syndrome; myocarditis; platelet aggregation inhibitors; SARS-CoV-2; shock; systemic inflammatory response syndrome; tachypnea; troponin T; vomitingMyocarditiCoronary Artery Disease030204 cardiovascular system & hematologySARS-CoV-2 Kawasaki disease Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection Myocarditis Hypotension Multisystem inflammatory syndrome associated with coronavirus disease Coronary artery abnormalitiesCoronary artery diseaseSettore MED/38 - Pediatria Generale E Specialistica0302 clinical medicineGlucocorticoidImmunologic FactorMultisystem inflammatory syndrome associated with coronavirus diseaseImmunology and AllergyChildCoronary artery abnormalitieFisher's exact testPediatricTachypneabiologylcsh:RJ1-570Antirheumatic AgentImmunoglobulins IntravenousShockPediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infectionSettore MED/38Systemic Inflammatory Response SyndromeIntensive Care UnitsMyocarditisC-Reactive ProteinItalyAntirheumatic AgentsChild PreschoolCohortsymbolsPlatelet aggregation inhibitorFemaleHypotensionIntravenousCoronary artery abnormalitiesHumanResearch ArticleDiarrheamedicine.medical_specialtyMyocarditisVomitingImmunoglobulinsMucocutaneous Lymph Node SyndromeIntensive Care Units Pediatric03 medical and health sciencessymbols.namesakeAge DistributionRheumatologyTroponin TInternal medicineLymphopeniamedicineHumansImmunologic FactorsPreschoolGlucocorticoids030203 arthritis & rheumatologyHeart FailureAspirinKawasaki diseasebusiness.industrySARS-CoV-2Platelet Aggregation InhibitorC-reactive proteinCOVID-19Infantlcsh:Pediatricsmedicine.diseaseSystemic inflammatory response syndromeInterleukin 1 Receptor Antagonist ProteinDyspneaCoughImmunoglobulins IntravenouPediatrics Perinatology and Child Healthbiology.proteinKawasaki diseaseHyperferritinemialcsh:RC925-935businessPlatelet Aggregation InhibitorsPediatric rheumatology online journal
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Methods to investigate coronary microvascular function in clinical practice.

2012

A growing amount of data is increasingly showing the relevance of coronary microvascular dysfunction (CMVD) in several clinical contexts. This article reviews techniques and clinical investigations of the main noninvasive and invasive methods proposed to study coronary microcirculation and to identify CMVD in the presence of normal coronary arteries, also trying to provide indications for their application in clinical practice.

Diagnostic Imagingmedicine.medical_specialtymyocardial contrast echocardiographyCoronary microcirculationCoronary Artery DiseaseCoronary microvascular functionDiagnostic toolsintracoronary Doppler ultrasoundMicrocirculationcoronary microcirculationtransthoracic Doppler echocardiographyCoronary artery diseaseCoronary circulationcardiovascular magnetic resonanceInternal medicineCoronary CirculationmedicineDIAGNOSTIC TOOLSHumansNormal coronary arteriesbusiness.industryMicrocirculationGeneral Medicinemedicine.diseaseSettore MED/11 - Malattie Dell'Apparato Cardiovascolarediagnostic investigationClinical PracticeMyocardial contrast echocardiographymedicine.anatomical_structurePETcardiovascular magnetic resonance; coronary microcirculation; diagnostic investigation; intracoronary Doppler ultrasound; myocardial contrast echocardiography; PET; transthoracic Doppler echocardiography; Coronary Artery Disease; Coronary Circulation; Diagnostic Imaging; Humans; Microcirculation; Cardiology and Cardiovascular MedicineSettore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARECardiologymicrovascular functionHEARTCORONARYbusinessCardiology and Cardiovascular Medicine
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Non-coding RNAs and Coronary Artery Disease

2020

Coronary artery disease (CAD) is the leading death cause worldwide. Non-coding RNA (ncRNA) are key regulators of genetic expression and thus can affect directly or indirectly the development and progression of different diseases. ncRNA can be classified in several types depending on the length or structure, as long non-coding RNA (lncRNA), microRNA (miRNA) and circularRNA (circRNA), among others. These types of RNA are present within cells or in circulation, and for this reason they have been used as biomarkers of different diseases, therefore revolutionizing precision medicine. Recent research studied the capability of circulating ncRNA to inform about CAD presence and predict the outcome …

Enfermedad cardiovascularRNABiomarkerDiseaseComputational biologyGenética humanaBiologyNon-coding RNAPrecision medicinemedicine.diseaseARNCoronary artery disease (CAD)Coronary artery disease03 medical and health scienceslncRNA0302 clinical medicineBiomarker; Coronary artery disease (CAD); circRNA; lncRNA; miRNAGene expressionmicroRNAmedicineBiomarker (medicine)Cardiopatía coronariacircRNA030212 general & internal medicinemiRNA
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Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

2022

AIMS Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic-effects might be responsible for part of the unaccounted genetic variance. Here we attempted a proof-of-concept study to identify non-additive genetic effects, namely epistatic interactions, associated with CAD. METHODS AND RESULTS We tested for epistatic interactions in ten CAD case-control studies and UK Biobank with focus on 8,068 SNPs at 56 loci with known associations with CAD risk. We identified a SNP pair located in cis at the LPA locus, rs1800769 …

GeneticsPhysiologyMedizinEpistasis GeneticSingle-nucleotide polymorphismLocus (genetics)Genome-wide association studyCoronary Artery DiseaseBiologyPolymorphism Single NucleotideMinor allele frequencyCardiovascular DiseasesStatistical Genetics ; Epistasis ; Coronary Artery Diseases ; LpaPhysiology (medical)Genetic predispositionHumansAdditive genetic effectsEpistasisGenetic Predisposition to DiseaseCardiology and Cardiovascular MedicineGenome-Wide Association StudyLipoprotein(a)Genetic association
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