Search results for " DAMAGE"
showing 10 items of 1139 documents
[OP.3B.03] INFLUENCE OF SUBCLINICAL RENAL DAMAGE ON EARLY VASCULAR AGING IN PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS
2016
Objective: It is well known that kidney is frequently involved in patients with Systemic Lupus Erythematosus (SLE) However, conflicting data exist about the impact of renal involvement on vascular damage in this group of patients. The aim of this study was to evaluate the influence of renal damage on assessed by aortic pulse wave velocity (aPWV), evaluated a by intima-media thickness (IMT) measurement and assessed by renal resistive index (RRI) measurement, in patients with SLE. Design and method: We enrolled 52 SLE subjects (mean age 39 +/- 12 years), divided in two subgroups according to ACR/SLICC classification: patients with lupus nephritis, (LNG), and individuals presenting other featu…
SUBCLINICAL RENAL DAMAGE IS ASSOCIATED WITH A REDUCED CHOROIDAL THICKNESS IN PATIENTS WITH PRIMARY HYPERTENSION
2018
Objective: The retina is considered the easiest accessible window to study the state of the systemic microcirculation, even if the choroid is the most important vascular layer of the eye. Our understanding of the choroid has been greatly increased in last years since the introduction of advanced techniques of optical coherence tomography (OCT). Our study was aimed to assess choroidal thickness by using Swept-Source OCT (SS-OCT) in essential hypertensive patients (EHs) with and without subclinical renal damage (SRD). Design and method: We enrolled 100 EHs of which 65 without kidney damage and 35 with SRD. In all the participants SS-OCT and a routine biochemical work-up were performed. Glomer…
[OP.7D.07] 24-HOUR CENTRAL BLOOD PRESSURE IS BETTER ASSOCIATED WITH TARGET ORGAN DAMAGE OF HYPERTENSION THAN BRACHIAL BLOOD PRESSURE
2017
Objective: The VASOTENS international, multicenter, observational, non-randomized, prospective study aims at evaluating the impact of 24-hour pulse wave analysis of ambulatory blood pressure (BP) recordings on target organ damage and cardiovascular prognosis of hypertensive patients. In the present analysis of study baseline data we checked whether organ damage of hypertension i) is better associated with 24-hour central than peripheral BP and ii) is related to ambulatory arterial stiffness, estimated by pulse wave velocity (PWV) and augmentation index (AIx). Design and method: In 334 hypertensive patients (mean age 53+/-15, 52% males, 45% treated) we obtained 24-hour ABPMs, echocardiograms…
Responsabilità per trattamenti tricologici: casistica ed indagine conoscitiva
2012
The Authors report two cases of refund claim of personal damages for presumed professional responsibility of hairdressers, related to professional activities for trichological procedures. In fact acquired data show that, in the last years, there are many claims, even in civil litigation, for presumed professional responsibility concerning cosmetic medical-surgical practices, but also of typically moving crafts, for activities performed by these professionals. So, for many aspects of these events, medical examiner, is involved in the evaluation of causation between performed activities and complained subsistence of sequelae that could be considered damage of good constitutionally protected. …
Biochemical Factors and Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma
1992
A distinction between primary and secondary manifestations of brain damage from acute insults, such as trauma, or ischemia is not only of scientific interest but also of the highest clinical significance. After all, prevention of secondary brain damage in patients with severe head injury or cerebral ischemia is the ultimate purpose of treatment, including the measures of emergency care. It can be assumed that the secondary sequelae of head injury are as important for the outcome as the primary insult is. Therefore, it is obvious that development of more effective forms of treatment requires a better understanding of the mechanisms underlying secondary brain damage. Manifestations of seconda…
Gli ingegneri camerali in Sicilia dopo il terremoto del 1823
2016
La memoria intende indagare, attraverso lo studio delle fonti bibliografiche e soprattutto di una copiosa documentazione archivistica, il ruolo determinante svolto dalle istituzioni attraverso l’attività degli ingegneri camerali, tecnici alle dirette dipendenze dell’amministrazione regia, tra i quali emergono alcuni tra i professionisti più attivi del tempo quali Luigi Speranza, Giuseppe Patti e Alessandro Emmanuele Marvuglia. Questi ultimi vennero incaricati di effettuare numerosi sopralluoghi nelle zone colpite dal terremoto al fine di valutare e monitorare i danni, redigendo sia quadri di carattere generale relativi ai singoli centri, che perizie di dettaglio volte all’accertamento dei d…
Incipient damage identification through characteristics of the analytical signal response
2008
The analytical signal is a complex representation of a time domain signal: the real part is the time domain signal itself, while the imaginary part is its Hilbert transform. It has been observed that damage, even at a very low level, yields clearly detectable variations of analytical signal quantities such as phase and instantaneous frequency. This observation can represent a step toward a quick and effective tool to recognize the presence of incipient damage where other frequency-based techniques fail. In this paper a damage identification procedure based on an adimensional functional of the square of the difference between the characteristics of the analytical theoretical and measured sig…
Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays
2019
International audience; The human genome is replete with repetitive DNA sequences that can fold into thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular enzymes exist to cope with these structures whose stable accumulation would result in DNA damage through interference with DNA transactions such as transcription and replication. Therefore, the chemical stabilization of secondary DNA structures offers an attractive way to foster DNA transaction-associated damages to trigger cell death in proliferating cancer cells. While much emphasis has been recently given to DNA quadruplexes, we focused here on three-way DNA junctions (TWJ) and report on a strategy t…
Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)2]: study of its interaction with DNA and hydrogen peroxide
2001
A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; α=112.05(2), β=93.92(2), γ=108.30(2)° and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N s u l f o n a m i d a t e and N q u i n o l i n e atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.
Piezospectroscopic study of mechanical stress in Al2O3:Cr under swift heavy ion irradiation
2009
Abstract The spatial distribution of mechanical stresses in Al2O3:Cr single crystal irradiated with (1 ÷ 3) MeV/amu Kr, Xe and Bi ions has been studied by using laser confocal scanning microscopy technique. The stress level as a function of the ion penetration depth has been evaluated from depth-resolved photostimulated R-line luminescence spectra exploiting the piezospectroscopic method. As it was found, the stress field generated by swift heavy ion irradiation is composed of stresses with maximal magnitude comparable with the ultimate stress limit of ruby crystals. Experimental data are discussed in the framework of a model considering the Cr3+ atoms as individual piezosensors.