Search results for " DEMENTIA"

A SOCIAL EXPERIMENT TO OVERTURN PREJUDICES ON ALZHEIMER’S DISEASE IN NURSING HOMES USING ARTISTIC PHOTOGRAPHY

2016

It is widely known that Alzheimer’s disease is burdened with strong prejudices with negative connotations. This may contribute to increase patient’s isolation and marginalization, and to render Nursing Homes places of confinement and seclusion. Residents with dementia have trouble in relating with the outside world and in expressing themselves about their own disease, due to their cognitive decline, but also because of marginalization. We used artistic photography as an accessible and effective tool to bring down barriers and encourage residents’ communication. Artistic photography is the most immediate and accessible form of art for all people. The aim of our social experiment was to help …

OXIDATIVE STRESS AND ALZHEIMER’S DISEASE

2012

Introduction: Brain tissue is particularly susceptible to oxidative damage, which has been associated with pathological findings of Alzheimer’s disease (AD), such as amyloid plaques and protein fibrils. Oxidative stress alterations, including increased production of reactive oxygen metabolites, decline of antioxidant systems, and decreased efficiency in repairing damaged molecules, have been linked to the development of AD. Postmortem studies on brain tissue from AD patients have shown several oxidative damage markers, such as increased lipid peroxidation, oxidative damage of proteins, glyco-oxidation, and reduction of antioxidant enzyme systems. Methods: We studied 40 patients referred to …

Methodological matters on an Alzheimer's dementia trial: is a double-blind randomized controlled study design sufficient to draw strong conclusions o…

2007

Letter to Editor

MAGNESIUM AND ALZHEIMER’S DISEASE: IMPLICATIONS FOR DIET AND NUTRITION

2015

Rey-Osterrieth Complex figure performance in patients with degenerative dementia using Boston Qualitative Scoring System

2013

Frequency and clinical features of progranulin mutation carriers in a series of patients affected by frontotemporal lobar de generation: report of a …

2010

Mitochondrial DNA TRNACYS mutation in a family with frontotemporal dementia and Parkinson’s disease

2010

Subventricular zone in motor neuron disease with frontotemporal dementia.

2011

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress

2020

Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a growing body of evidence that links air pollution not only to adverse cardiorespiratory effects but also to increased risk of cerebrovascular and neuropsychiatric disorders. Despite being a relatively new area of investigation, overall, there is mounting recent evidence showing that exposure to multiple air pollutants, in particular to fine particles, may affect the central nervous system (CNS) and brain health, thereby contributing to …

C9ORF72 in a Large Series of Italian and Sardinian Familial and Sporadic ALS Patients (IN9-1.003)

2012

Objective: To assess the frequency and the phenotype of a large series of Italian sALS and fALS with C9ORF72 repeat expansions. Background Recently we found that large expansions of hexanucleotide repeats (GGGGCC) in the first intron of the C9ORF72 gene, located in the chromosome 9p21, are related to familial and sporadic ALS cases(Renton et al, 2011). Design/Methods: We assessed 126 index fALS (106 Italians, 20 of Sardinians) and 601 sALS (485 Italians, 116 Sardinians), negative for other ALS-related genes mutations. Patients were collected through the ITALSGEN consortium. Repeat primer PCR to screen the presence of the hexanucleotide expansion in the first intron of C9ORF72 have been perf…