Search results for " DIABET"
showing 10 items of 3021 documents
Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes
2022
Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in lipid metabolism and hence in maintaining metabolic health. We have previously introduced a hypothesis suggesting that BCAA degradation mechanistically connects to lipid oxidation and storage in skeletal muscle. To test our hypothesis, the present study examined the effects of BCAA deprivation and supplementation on lipid oxidation, lipogenesis and lipid droplet characteristics in murine C2C12 myotubes. In addition, the role of myotube contract…
Heart rate recovery after exercise and maximal oxygen uptake in sedentary patients with type 2 diabetes
2015
Aims: Heart rate recovery after exercise (HRR) is an estimate of autonomic modulation of the heart, and has been shown to be inversely associated with insulin resistance, metabolic syndrome, and type 2 diabetes [1]. Type 2 diabetes is associated with poor exercise tolerance and maximal aerobic capacity (VO2max) [2]. Aim of our study was to assess the relationship between HRR and VO2max in sedentary patients with type 2 diabetes. Methods: Maximal treadmill exercise testing using standard or modified Bruce protocol was performed in 16 (8 males and 8 females) sedentary patients with type 2 diabetes (T2D), and in 16 (9 males and 7 females) age-matched sedentary non-diabetic controls (ND). HRR (…
Pirmā tipa cukura diabēta pacientu klīniskais novērojums endokrinologa praksē: metabolās kompensācijas novērtējums, akūto komplikāciju blakusslimību …
2017
Pētījuma darba galvenais mērķis ir analizēt dažāda smaguma hipoglikēmiju biežumu pirmā tipa cukura diabēta pacientiem un salīdzināt to ar diabēta metabolo kompensāciju. Materiāli un metodes: pētījumā tika analizētas „Latvijas Universitātes Medicīniskās pēcdiploma izglītības institūta” Dr.med. Kristīnes Ducenas pacientu ambulatorās kartes. Tika analizēti pacientu dati ar apstiprinātu diagnozi – pirmā tipa cukura diabēts. Atsevišķi tika apstrādāti dati par pacienta dzimumu, vecumu, cukura diabēta ilgumu (gados), HbA1C līmeni un citām autoimūnām blakussaslimšanām. Atkarībā no HbA1c līmeņa, pētījuma dalībnieki tika sadalīti sekojošās grupās: ●Pirmā grpa- laba diabēta kompensācija (HbA1c 7,5%). …
Atherosclerosis: risk assessment and the role of aiming for optimal glycaemic control in young patients with type 1 diabetes
2023
Wprowadzenie: Dzieci z cukrzycą typu 1 (type 1 diabetes mellitus – DM1) mają w porównaniu ze zdrowymi rówieśnikami podwyższone ryzyko rozwoju zaawansowanej miażdżycy oraz choroby sercowo-naczyniowej (cardiovascular disease – CVD), a niedostateczna kontrola glikemii jest najważniejszym modyfikowalnym czynnikiem ryzyka CVD w DM1. Aktualne metody oceny kontroli glikemii to ocena hemoglobiny glikowanej (HbA1c), samokontrola glikemii za pomocą glukometru (SMBG), a także stosowanie systemów ciągłego monitorowania glukozy (CGM). Do pośredniej oceny ryzyka rozwoju CVD mogą służyć badania rozszerzenia tętnicy w odpowiedzi na niedokrwienie (flow-mediated dilatation – FMD) i prędkości fali tętna (PWV)…
Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control
2008
Background: Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim: Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods: In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results: The pre–post course showed that already in the first quarter, a statis…
Tapaustutkimus tyypin 2 diabetesasiakkaan liikuntapuheesta ja motivoivan haastattelun menetelmien ilmenemisestä diabeteshoitajan liikuntaneuvonnassa
2011
Tutkielman tarkoituksena oli tutkia, miten motivoivan haastattelun menetelmät ilmenivät diabeteshoitajan toteuttamassa liikuntaneuvonnassa sekä arvioida tyypin 2 diabetesasiakkaan liikuntaan motivoitumiseen ja sitoutumiseen yhteydessä olevia tekijöitä kahden vuoden seuranta-aikana. Tutkimusaineisto oli osa Jyväskylän yliopiston Terveystieteiden laitoksen diabetespotilaiden terveysneuvonnan seurantatutkimusta (2000 - 2002). Tässä tutkimuksessa käytetty aineisto koostui tyypin 2 diabetesasiakkaan ja diabeteshoitajan videoiduista ja litteroiduista terveysneuvontatilanteista kahden vuoden seuranta-aikana. Liikuntaan liittyvät puheenvuorot irrotettiin tutkimuksen kohteeksi ja aineisto analysoiti…
Progestogens and risk of breast cancer: a link between bone and breast?
2015
This article reviews the data supporting the role of receptor activator of the nuclear factor kappa (RANK) and its ligand, RANKL, in progestogen-induced breast cancer. Both experimental and clinical studies have been included. The expression of both RANK and RANKL has been described in epithelial cells of both mice and humans. Experiments of gain and loss of function in mice have shown that RANK/RANKL mediate alveologenesis during pregnancy or the estrous cycle. Moreover, the participation of the RANK/RANKL has been detected in models of breast carcinogenesis associated with progestogens-like medroxyprogesterone acetate. Recent clinical studies have found that the expression of RANK is asso…
Assessment of the tibia using ultrasonic guided waves in pubertal girls
2002
The purpose of this study was to compare low frequency ultrasonic guided wave measurements with established ultrasound and bone density measurements in terms of their ability to characterize the tibia in pubertal girls. Subjects were 12-14-year-old girls ( n=106) who were participating in a calcium and vitamin D intervention study. A prototype low frequency pulse transmission device consisting of a uniaxial scanning mechanism and low frequency transducers orientated perpendicularly to the limb was used to measure two ultrasound velocities in the tibia. The first velocity, V1, was that of the first arriving signal, similar to that measured by existing commercial tibial ultrasound devices. Th…
Case Report: Unmasking Hypercalcemia in Patients With Neuroendocrine Neoplasms. Experience From Six Italian Referral Centers
2021
BackgroundHypercalcemia is a common paraneoplastic syndrome which can occur in up to 10% of patients with advanced neoplasms. Paraneoplastic parathyroid hormone-related protein (PTHrP) represents the most frequent cause of this syndrome. In neuroendocrine neoplasms (NENs) paraneoplastic hypercalcemia is rare.Case SeriesThe present series includes all patients with NENs and paraneoplastic hypercalcemia from four Italian centres: (I) A 40-year-old man was hospitalized for repeated episodes of falls, hyposthenia and drowsiness. Severe hypercalcemia was found. Metastatic pancreatic G2 NEN and PTHrP-related hypercalcemia were diagnosed. The patient started therapy with somatostatin analogs (SSA)…
HLA Class II Differentiates Between Thyroid and Polyglandular Autoimmunity.
2015
The HLA class II genes are susceptibility genes for autoimmune endocrine diseases; however, scarce data are available pertaining to the determinants of genetic susceptibility to polyglandular autoimmunity (PGA). A total of 300 consecutive and unselected patients with either PGA or monoglandular autoimmune thyroid disease (AITD) and 100 healthy control subjects were genotyped for the HLA class II DRB1, -DQA1, and -DQB1 alleles. Compared to patients with AITD and controls, the HLA-DRB1*03 (pc =0.001), *04 (pc<0.001), -DQA1*03 (pc<0.001), and -DQB1*02 (pc =0.001) alleles were increased in patients with PGA. When dividing patients with Hashimoto's thyroiditis (HT) into those with PGA (PGA-HT) v…