Search results for " DOC"
showing 10 items of 1281 documents
Design of antitumor drugs targeting c-kit receptor by a new mixed ligand-structure based method
2020
An important challenge, in the medicinal chemistry field, is the research of novel forceful drugs to overcome tumor-acquired resistance. The c-Kit tyrosine kinase receptor (TKR) represents a suitable target for the carcinogenesis control of gastro-intestinal stromal (GIST), leukemia, and mastocytosis tumors; nevertheless, several hotspot mutations of the protein limit the efficacy of a few clinical administered TKRs inhibitors. In this study, a new in silico protocol based on ligand and structure-based combined method is proposed, with the aim to identify a set of new c-Kit inhibitors able to complex c-Kit mutated proteins. A recent and freely available web-server DRUDIT is used for the lig…
Experimental-Like Affinity Constants and Enantioselectivity Estimates from Flexible Docking
2012
Experimental-like affinity constants and enantioselectivity estimates, not predicted so far computationally, were obtained using a novel flexible modeling/docking combined strategy. The S- and R-warfarin-human serum albumin (HSA, site I) complexes were used as an interaction model. The process for a verified estimation includes the following: (i) ionized open chain forming at physiological pH (a recent focus); (ii) conformational search (molecular mechanics and Monte Carlo methods); (iii) rigid protein-flexible ligand docking (GlideXP) generating low energy paired S- and R-poses; (iv) graphical comparison against the X-ray crystal structure (unsatisfactory verification step); (v) quantum po…
Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-based Pharmacophore Modeling/Docking Approach
2020
To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no approved therapies for treating this coronavirus infection. The process of new drug development is expensive and time-consuming, so that drug repurposing may be the ideal solution to fight the pandemic. In this paper, we selected the proteins encoded by SARS-CoV-2 and using homology modeling we identified the high-quality model of proteins. A structure-based pharmacophore modeling study was performed to identify the pharmacophore features for each…
Creences de docents shipibo-konibo, envers el joc infantil i el seu paper a l'escola
2019
espanolEl juego es un espacio fundamental para el desarrollo infantil que permite a los ninos explorar el entorno y a si mismos de modos cada vez mas complejos, construir conocimiento, vincularse y cooperar con los otros y adaptarse al mundo de forma flexible. En la escuela, el juego impulsa la construccion de aprendizajes significativos y otorga mayor motivacion para aprender. Sin embargo, a pesar de esto el juego esta desapareciendo de los procesos educativos. Dado que las creencias docentes tienen implicancias directas en lo que ocurre en las aulas de clases, esta investigacion tiene como objetivo explorar las creencias sobre el juego de docentes de tres comunidades Shipibo-Konibo de la …
La hostelería valenciana: un sector en cambio
1988
ESTE ARTICULO INTENTA ANALIZAR LA HOSTELERIA DE LA COMUNIDAD VALENCIANA, SECTOR TURISTICO TRADICIONAL QUE SUFRE HOY LA DURA COMPETENCIA DE OTRAS FORMAS DE ALOJAMIENTO. ADEMAS, SU ESTRUCTURA POPULAR Y MINIFUNDISTA Y LA FUERTE ESTACIONALIDAD DE SU DEMANDA SON PROBLEMAS AÑADIDOS QUE NECESITAN UNA URGENTE SOLUCION PARA SALIR DE LA CRISIS ACTUAL. (A)
Leitbilder im Recht: Grenzen der Ordnung – Chancen der Unordnung
2018
„Guiding principles“ as topoi in German juridical discourse are mainly analyzed with regard to their relation to familiar dogmatic and methodological categories. This article suggests engaging with a deconstructing, psychoanalysis-inspired approach to the guiding principles of legal discourse.
La Modelización como herramienta de evaluación competencial
2016
[EN] The concept of competency has become more and more important in our educational system, partly due because of external tests assessing educational quality, as PISA, highlight the need not only to introduce methodological changes in the teaching of mathematics in the Secondary education, but also to design new tools in order to develop mathematical competence, understood as the ability of our students to mathematize real life situations. In this thesis we want to study the role that modelling tasks can play in the development of mathematical competency, and, particularly, in problem solving. For this aim, we have designed a series of modelling tasks based on three different perspectives…
Design, Synthesis and Biological Evaluation of 7-Chloro-9
2019
Glycogen synthase kinase-3β (GSK-3β) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer’s disease. We herein report on the optimization of a novel class of GSK-3β inhibitors based on the tofacitinib-derived screen hit 3-((3R,4R)-3-((7-chloro-9H-pyrimido[4,5-b]indol-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile (1). We synthesized a series of 19 novel 7-chloro-9H-pyrimido[4,5-b]indole-based derivatives and studied their structure–activity relationships with focus on the cyanoacetyl piperidine moiety. We unveiled the crucial role of the nitrile group and its importance for the activity of this compound series. A successfu…
Análisis de las calificaciones compartidas en la modalidad participativa de la evaluación colaborativa entre docente y estudiantes
2020
Current trends in educational assessment in different branches of higher education share the common goal of uniting learning with assessment. Most approaches and theoretical and practical developments in this field revolve around four main factors: feedback, democratization, alignment and relevance. This paper proposes the use of co-assessment as a means of ensuring dialogue-based, democratic and fairer evaluations. With co-assessment, the responsibility is shared by the teacher and the students, who negotiate and agree on the appraisal of student tasks and, in this paper, also on the awarded mark. The aim of this study is to analyse the relationship between a series of jointly agreed marks…
Competency Profile of the Elementary School Teacher : analysis of Pre-service Elementary School Teacher's Opinion
2014
ResumenEl objeto del presente estudio se centra en conocer la opinión del alumnado de la primera promoción del Grado en Educación Primaria de la Universidad de La Rioja (n=105) sobre las competencias que configuran el perfil del docente, con el fin de contrastarla con los resultados que nos brinda la investigación y esbozar propuestas para la formación de los futuros maestros. Para tal fin se diseña y administra un autoinforme integrado por diferentes atributos presentados en un formato de respuesta de tipo Likert. Los resultados han derivado en dos escalas; la primera determina el ser del docente y se agrupa en competencias para saber hacer y en competencias afectivo-emocionales; la segund…