Search results for " DOM"
showing 10 items of 2750 documents
Influence of the quadratic term in the alongwind stochastic response of SDOF structures
1996
A parametric study, regarding the influence of the quadratic pressure term, which is often neglected in the literature, on the stochastic alongwind response of a single-degree-of-freedom (SDOF) structure subjected to wind action, is presented. The results are reported in terms of percentages of difference in the evaluation of the response, by considering and neglecting the quadratic pressure term. The changing parameters considered are: the terrain drag coefficient, the structure height, the structure natural radian frequency, the structure damping coefficient and the wind reference mean velocity. The response stochastic analysis has been carried out in the time domain, by means of the mome…
Rappresentazioni vertiginose. Tre esempi: Perec, Lequeu, Douat
2022
Nel novembre del 2009 il Museo del Louvre decise di affidare a Umberto Eco la direzione di una serie di conferenze da tenere su un argomento di sua scelta. Eco scelse il tema della ‘lista’ conferendo a quella manifestazione il nome di Vertige de la liste a cui seguì un saggio dallo stesso titolo pubblicato da Bompiani. Questa breve nota prende in prestito la stessa tematica che, per via del suo carattere altamente ete-rogeneo, è in grado di coinvolgere diversi ambiti del sapere senza minimamente accennare ad esaurirsi. L’elenco, strettamente legato alla figura retorica dell’accumulazione, può infatti costituirsi di segni, parole, suoni e di qualsiasi altra forma di rappresentazione utile a …
Protocol for rational design of covalently interacting inhibitors.
2014
The inhibition potencies of covalent inhibitors mainly result from the formation of a covalent bond to the enzyme during the inhibition mechanism. This class of inhibitors has essentially been ignored in previous target-directed drug discovery projects because of concerns about possible side effects. However, their advantages, such as higher binding energies and longer drug-target residence times moved them into the focus of recent investigations. While the rational design of non-covalent inhibitors became standard the corresponding design of covalent inhibitors is still in its early stages. Potent covalent inhibitors can be retrieved from large compound libraries by covalent docking approa…
Modeling of Cell Membrane Targeting: Specific Recognition, Binding, and Protein Domain Formation in Ligand-Containing Model Biomembranes
1990
Drug delivery systems are designed to assist, accelerate, and control transport of pharmacologically active agents from sites of administration to specified targets in organs and tissues. So-called controlled drug delivery systems are intended to maintain continuously efficacious drug concentrations in vivo, either locally or systemically, over longer time periods. They should provide constant dosage levels above a minimum level of efficacy yet below mandated toxicity levels — a significant advantage over many conventional systemically administered formulations. Site-specific targeting of drugs, particularly those agents which prove highly toxic in small doses, can be utilized to maintain t…
Mpdz is a quantitative trait gene for drug withdrawal seizures
2004
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
2021
The identification of chemical compounds able to bind specific sites of the human/viral proteins involved in the SARS-CoV-2 infection cycle is a prerequisite to design effective antiviral drugs. Here we conduct a molecular dynamics study with the aim to assess the interactions of ivermectin, an antiparasitic drug with broad-spectrum antiviral activity, with the human Angiotensin-Converting Enzyme 2 (ACE2), the viral 3CLpro and PLpro proteases, and the viral SARS Unique Domain (SUD). The drug/target interactions have been characterized in silico by describing the nature of the non-covalent interactions found and by measuring the extent of their time duration along the MD simulation. Results …
The embodiment of wastewater data for the estimation of illicit drug consumption in Spain
2021
Data obtained from wastewater analysis can provide rapid and complementary insights in illicit drug consumption at community level. Within Europe, Spain is an important country of transit of both cocaine and cannabis. The quantity of seized drugs and prevalence of their use rank Spain at the top of Europe. Hence, the implementation of a wastewater monitoring program at national level would help to get better understanding of spatial differences and trends in use of illicit drugs. In this study, a national wastewater campaign was performed for the first time to get more insight on the consumption of illicit drugs within Spain. The 13 Spanish cities monitored cover approximately 6 million inh…
Descriptive and hedonic temporal sensory analysis
2016
Over the last years, so-called rapid methods for sensory evaluation have been developed to collect sensory description of products from consumers. Moving forward in this direction, this thesis proposes to pair Temporal Dominance of Sensations (TDS) with dynamic liking. This new method, named Temporal Drivers of Liking (TDL), highlights sensory drivers of consumer liking and determines how the dynamic perception can impact the hedonic response. This work proposes to compute the Liking While Dominant (LWD) score as the average liking scores given to a product while a given attribute was perceived as dominant and to look at its deviation from the mean liking score of this product. When signifi…
On the Non-Intrusive Load Monitoring in dwellings: a feasibility perspective
2021
The oncoming modernization process of the power grids, driven above all by decarbonisation objectives and the continuous improvement of digital technologies, is encouraging active participation in the electricity market by consumers through the Demand-Response mechanism. From this perspective, the introduction of smart meters and energy consumption monitoring devices plays a fundamental role, being able to give benefits to consumers, suppliers and the electricity grid itself. This paper proposes a supervised method of non-intrusive load monitoring (NILM) based on the recognition of patterns in the time domain with the Dynamic Time Warping algorithm which is suitable for low-cost smart meter…
Stochastic response determination of structural systems modeled via dependent coordinates: a frequency domain treatment based on generalized modal an…
2019
Generalized independent coordinates are typically utilized within an analytical dynamics framework to model the motion of structural and mechanical engineering systems. Nevertheless, for complex systems, such as multi-body structures, an explicit formulation of the equations of motion by utilizing generalized, independent, coordinates can be a daunting task. In this regard, employing a set of redundant coordinates can facilitate the formulation of the governing dynamics equations. In this setting, however, standard response analysis techniques cannot be applied in a straightforward manner. For instance, defining and determining a transfer function within a frequency domain response analysis…