Search results for " Databases"
showing 10 items of 140 documents
The Italian multiple sclerosis register
2019
The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the …
Years of life that could be saved from prevention of hepatocellular carcinoma
2016
Summary Background Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim To assess how many years of life are lost after HCC diagnosis. Methods Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18–61 y…
RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures
2020
The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life. The accumulation of solved repeat structures provides new possibilities for classification and detection, but also increasing the need for annotation. Here we present RepeatsDB 3.0, which addresses these challenges and presents an extended classification scheme. The major conceptual change compared to the previous version is the hierarchical classification combining top levels based solely on structural similarity (Class > Topology > Fold) with two new lev…
Monitoring the rate of hospitalization before rotavirus immunization in Italy utilizing ICD9-CM regional databases
2009
BACKGROUND: Recently, two Rotavirus (RV) vaccines were licensed in Italy, rendering RV illness a vaccine preventable disease. To assess the RV hospitalization rate in Italy, a study focused on the Regional hospital discharge forms (HDD) databases was carried out. RESULTS: Regional HDD databases from Piemonte, Veneto, Friuli-Venezia-Giulia and Marche were analyzed. A total of 434,335 hospitalizations were counted in the study timeframe and 13,234 VE diagnoses (3% of hospitalizations) were collected. A total of 8546 RVE cases (2% of hospitalizations, 64% of all VE) were observed, of which 1.2% were primary diagnoses (PD) and 0.8% secondary diagnosis (SD). The RVE hospitalization peak (4.9%) w…
Salinity and Bacterial Diversity: To What Extent Does the Concentration of Salt Affect the Bacterial Community in a Saline Soil?
2014
In this study, the evaluation of soil characteristics was coupled with a pyrosequencing analysis of the V2-V3 16S rRNA gene region in order to investigate the bacterial community structure and diversity in the A horizon of a natural saline soil located in Sicily (Italy). The main aim of the research was to assess the organisation and diversity of microbial taxa using a spatial scale that revealed physical and chemical heterogeneity of the habitat under investigation. The results provided information on the type of distribution of different bacterial groups as a function of spatial gradients of soil salinity and pH. The analysis of bacterial 16S rRNA showed differences in bacterial compositi…
A Data Association Algorithm for People Re-Identification in Photo Sequences
2010
In this paper, a new system is presented to support the user in the face annotation task. Every time a photo sequence becomes available, the system analyses it to detect and cluster faces in set corresponding to the same person. We propose to model the problem of people re-identification in photos as a data association problem. In this way, the system takes advantage from the assumption that each person can appear at most once in each photo. We propose a fully automated method for grouping facial images, the method does not require any initialization neither a priori knowledge of the number of persons that are in the photo sequence. We compare the results obtained with our method and with s…
Knowledge Discovery and Digital Cartography for the ALS (Linguistic Atlas of Sicily) Project
2009
In this paper the latest developments of the ALS (Linguistic Atlas of Sicily) project are presented. The ALS project has the purpose to define methodologies and tools to allow researches in the socio-linguistic field. Different types of variables (both quantitative and qualitative) are involved. The whole framework is based on the definition of ontology-based applications for the creation, retrieval, manipulation and browsing of related data. To this aim, some mapping processes have been defined. The framework eventually shows the result in many ways including spatial maps. The on-going collaboration process is a perfect example a domain hybridizing process, enabling the training on-the-fie…
Towards Mkda: A Data Mining Semantic Web Service
2008
Nowadays a huge amount of raw medical data is generated. These data, analyzed with data mining techniques, could be used to produce new knowledge. Unluckily such tasks need skilled data analysts, and not so many researchers in medical field are also data mining experts. In this paper we present a web based system for knowledge discovery assistance in Medicine able to advice a medical researcher in this kind of tasks. The experiment specifications are expressed in a formal language we have defined. The system GUI helps the user in the their composition. The system plans a Knowledge Discovery Process (KDP). The KDP is designed on the basis of rules in a knowledge base. Finally the system exec…
Towards MKDA: A Knowledge Discovery Assistant For Researches in Medicine
2007
Nowadays doctors are generating a huge amount of raw data. These data, analyzed with data mining techniques, could be sources of new knowledge. Unluckily such tasks need skilled data analysts, and not so much researchers in Medicine are also data mining experts. In this paper we present a web based system for knowledge discovery assistance in Medicine able to advice a medical researcher in this kind of tasks. The user must define only the experiment specifications in a formal language we have defined. The system GUI helps users in their composition. Then the system plans a Knowledge Discovery Process (KDP) on the basis of rules in a knowledge base. Finally the system executes the KDP and pr…
An Innovative Statistical Tool for Automatic OWL-ERD Alignment
2016
Aligning two representations of the same domain with different expressiveness is a crucial topic in nowadays semantic web and big data research. OWL ontologies and Entity Relation Diagrams are the most widespread representations whose alignment allows for semantic data access via ontology interface, and ontology storing techniques. The term ""alignment" encompasses three different processes: OWL-to-ERD and ERD-to-OWL transformation, and OWL-ERD mapping. In this paper an innovative statistical tool is presented to accomplish all the three aspects of the alignment. The main idea relies on the use of a HMM to estimate the most likely ERD sentence that is stated in a suitable grammar, and corre…