Search results for " Dermatitis"
showing 10 items of 131 documents
Langerhans cells regulate autoimmune CD8 T cell-mediated interface dermatitis
2017
CCL27 Signaling in the Tumor Microenvironment
2021
Chemokines are a group of small proteins which play an important role in leukocyte migration and invasion. They are also involved in the cellular proliferation and migration of tumor cells.Chemokine CCL27 (cutaneous T cell-attracting chemokine, CTACK) is mainly expressed by keratinocytes of the normal epidermis. It is well known that this chemokine plays an important role in several inflammatory diseases of the skin, such as atopic dermatitis, contact dermatitis, and psoriasis. Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in t…
53 Human bio-monitoring of epoxy resins and hardeners in the production of rotor: blades
2018
Introduction In a small company producing rotor blades for aviation from carbon composites, epoxy resins based on Novolac and isophorone diamine as hardener are used. Both compounds can be absorbed via skin contact and were shown to be strong skin sensitizers. As a part of risk assessment, the industrial physician prompted a biological monitoring to determine the internal exposure of the workers. Methods 6 workers were identified with potential contact to the hardener and resin. We have collected pre- and post-shift urine samples at the beginning and mid of the work week and analysed them for the concentration of isophoronediamine and bisphenol-f-diglycidylethermetabolites as biomarker for …
Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization
2014
A murine repeated protein-patch model has been established to study epicutaneous sensitization in atopic dermatitis. This model has shown a predominant Th2 and a weak Th1 response in both BALB/c and C57BL/6 mice. However, Th responses induced in the repeated model are not consistent with the generally accepted theory that BALB/c and C57BL/6 mice are Th2 and Th1 prone and are representatives of human atopy and non-atopy, respectively. In this study, a single protein-patch model was established, which showed in addition to the Th2 response, a remarkable Th1 response in C57BL/6 mice, but not in BALB/c mice. Moreover, using muLangerin-DTR mice, we demonstrated that dermal dendritic cells, but n…
Structure d'attachement dans la dermatite atopique
2011
Atopic dermatitis is an inflammatory skin disorder which usually appears before the age of five, and heals naturally little by little after adolescence in over 90% of cases. Why this spontaneous improvement occurs is not clearly established for this multi-factor skin disorder, for which the etiopathology has yet to be determined (immune system maturity?).There is a clear relationship between this pathology and the psyche: major psychological repercussions affecting the quality of life, aggravation or triggering of skin reactions due to stress, alleviation of lesions using psychotherapy. Observation of patterns of attachment is important in the field of psychopathology, but is not often unde…
Cyanocobalamin Ultraflexible Lipid Vesicles: Characterization and In Vitro Evaluation of Drug-Skin Depth Profiles
2021
Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory skin disorders, which importantly affect the quality of life of patients who suffer them. Among other causes, nitric oxide has been reported as part of the triggering factors in the pathogenesis of both conditions. Cyanocobalamin (vitamin B12) has shown efficacy as a nitric oxide scavenger and some clinical trials have given positive outcomes in its use for treating skin pathologies. Passive skin diffusion is possible only for drugs with low molecular weights and intermediate lipophilicity. Unfortunately, the molecular weight and hydrophilicity of vitamin B12 do not predict its effective diffusion through the skin…
Patients Withdrawing Dupilumab Monotherapy for COVID-19-Related Reasons Showed Similar Disease Course Compared With Patients Continuing Dupilumab The…
2022
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Efectos del cambio climático en las helmintiasis animales y zoonóticas
2008
Current knowledge of animal and zoonotic helminthiases in which effects of climate change have been detected is reviewed. Climate variables are able to affect the prevalence, intensity and geographical distribution of helminths, directly influencing free-living larval stages and indirectly influencing mainly invertebrate, but also vertebrate, hosts. The impact of climate change appears to be more pronounced in trematodes, and is mainly shown by increased cercarial production and emergence associated with global warming. Fascioliasis, schistosomiasis (S. japonicum) and cercarial dermatitis caused by avian schistosomes have been the focus of study. Alveolar echinococcosis is currently the onl…
The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
2021
Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin. According to recent research such phenomena are closely related to the microbial dysbiosis of the skin. There is growing evidence that cutaneous microbiota and bacterial biofilms negatively affect skin barrier function, contributing to the onset and exacerbation of AD. This review summarizes the latest data on the mechanisms leading to microbiome dysbiosis and biofilm formation in AD, and the influence of these phenomena on skin barrier function.
Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis.
2009
The capacity of climatic conditions to modulate the extent and intensity of parasitism is well known since long ago. Concerning helminths, among the numerous environmental modifications giving rise to changes in infections, climate variables appear as those showing a greater influence, so that climate change may be expected to have an important impact on the diseases they cause. However, the confirmation of the impact of climate change on helminthiases has been reached very recently. Only shortly before, helminthiases were still noted as infectious diseases scarcely affected by climate change, when compared to diseases caused by microorganisms in general (viruses, bacteriae, protozoans). Th…