Search results for " Design"
showing 10 items of 5050 documents
Double Flow Bioreactor for In Vitro Test of Drug Delivery.
2015
In this work, double-structured polymeric scaffolds were produced, and a double flow bioreactor was designed and set up in order to create a novel system to carry out advanced in vitro drug delivery tests. The scaffolds, consisting of a cylindrical porous matrix, are able to host cells, thus mimicking a three-dimensional tumor mass: moreover, a âpseudo-vascularâ structure was embedded into the matrix, with the aim of allowing a flow circulation. The structure that emulates a blood vessel is a porous tubular-shaped scaffold prepared by Diffusion Induced Phase Separation (DIPS), with an internal lumen of 2 mm and a wall thickness of 200 micrometers. The as-prepared vessel was incorporated…
Smart inulin-based polycationic nanodevices for siRNA delivery
2017
The advances of short interfering RNA (siRNA) mediated therapy provide a powerful option for the treatment of many diseases by silencing the expression of targeted genes including cancer development and progression. Inulin is a very simple and biocompatible polysaccharide proposed by our groups to produce interesting delivery systems for Nucleic Acid Based Drugs (NABDs), such as siRNA, either as polycations able to give polyplexes and polymeric coatings for nanosystems having a metallic core. In this research field, different functionalizing groups were linked to the inulin backbone with specific aims including oligoamine such as Ethylendiammine (EDA), Diethylediamine (DETA), Spermine, (SPM…
Multisensory texture exploration at the tip of the pen
2016
A tool for the multisensory stylus-based exploration of virtual textures was used to investigate how different feedback modalities (static or dynamically deformed images, vibration, sound) affect exploratory gestures. To this end, we ran an experiment where participants had to steer a path with the stylus through a curved corridor on the surface of a graphic tablet/display, and we measured steering time, dispersion of trajectories, and applied force. Despite the variety of subjective impressions elicited by the different feedback conditions, we found that only nonvisual feedback induced significant variations in trajectories and an increase in movement time. In a post-experiment, using a pa…
Design of Advanced Digital Systems Based on High-Speed Optical Links
2012
Optical fiber links offer very important benefits as EMI immunity, low losses, high bandwidth, etc, so an increasing number of communication applications are being developed and deployed. At both sides of these optical links, the optical data signal has to be converted to (or from) the electronic domain. The processing of such a high speed optical signals is not straightforward in most cases, and special considerations need to be taken into account for a proper electronic design.
Bim and architectural heritage: Towards an operational methodology for the knowledge and the management of cultural heritage
2016
The study aims to answer the growing need for virtuously organize informational apparatuses related to Cultural Heritage. We propose a methodology that integrates multidisciplinary processes of interaction with information aimed at survey, documentation, management, knowledge and enhancement of historic artifacts. It is needed to review and update the procedure of instrumental data acquisition, standardization and structuring of the acquired data in a three-dimensional semantic model as well as the subsequent representability and accessibility of the model and the related database. If the use of Building Information Modeling has in recent years seen a consolidation in the procedures and the…
Family background and problems at school and in society: The role of family composition, emotional atmosphere and parental education
1997
Three studies were carried out to examine the extent to which family composition, size and atmosphere, parental control, and the level of parental education and socioeconomic status, are associated with young people’s problems at school, and later on in society. In study 1, twenty-four 13- to 14-year-old underachievers, and 24 of their matched-pair controls, and 24 overachievers and 24 of their matchedpair controls, were compared according to their family background. In study 2, sixteen low achieving pupils, 20 vocational school pupils and 21 senior high school pupils, aged between 14 and 19, were examined. In study 3, twenty unemployed young adults, 14 students with health problems, and 23…
Problem Space Identification for Developing Virtual Reality Learning Environments
2021
Our study argues that the extant literature on virtual reality-based learning environments (VRLEs) currently lacks proper definitions and context descriptions for a problem space, which is fundamental for conducting design science research (DSR). Without properly conducted problem space identification, the most pivotal problems cannot be identified resulting solutions lacking validity and unreliable evaluations. This is a major challenge for the DSR in the educational field, but also for the research on VRLEs. The purpose of this paper is to introduce a novel DSR method to support rigorous problem space identification, which would allow rigorous and profound problem space analysis. The inst…
Rational Design of Thermoresponsive Microgel Templates with Polydopamine Surface Coating for Microtissue Applications.
2021
Functional microgels provide a versatile basis for synthetic in vitro platforms as alternatives to animal experiments. The tuning of the physical, chemical, and biological properties of synthetic microgels can be achieved by blending suitable polymers and formulating them such to reflect the heterogenous and complex nature of biological tissues. Based on this premise, this paper introduces the development of volume-switchable core-shell microgels as 3D templates to enable cell growth for microtissue applications, using a systematic approach to tune the microgel properties based on a deep conceptual and practical understanding. Microscopic microgel design, such as the tailoring of the microg…
Learning automata based energy-efficient AI hardware design for IoT applications
2020
Energy efficiency continues to be the core design challenge for artificial intelligence (AI) hardware designers. In this paper, we propose a new AI hardware architecture targeting Internet of Things applications. The architecture is founded on the principle of learning automata, defined using propositional logic. The logic-based underpinning enables low-energy footprints as well as high learning accuracy during training and inference, which are crucial requirements for efficient AI with long operating life. We present the first insights into this new architecture in the form of a custom-designed integrated circuit for pervasive applications. Fundamental to this circuit is systematic encodin…
Formulations and exact algorithms for the distance-constrained generalized directed rural postman problem
2017
[EN] The generalized directed rural postman problem is an arc routing problem with many interesting real-life applications, such as routing for meter reading. In this application, a vehicle with a receiver travels through a series of neighborhoods. If the vehicle gets closer than a certain distance to a meter, the receiver is able to record the gas, water, or electricity consumption. Therefore, the vehicle does not need to traverse every street, but only a few, to get close enough to each meter. We study an extension of this problem in which a fleet of vehicles is available. Given the characteristics of the mentioned application, the vehicles have no capacities but there is a maximum distan…