Search results for " Dose"
showing 10 items of 593 documents
Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DAL…
2014
The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The followi…
Ru-Based Thin Film Temperature Sensor for Space Environments: Microfabrication and Characterization under Total Ionizing Dose
2016
The paper shows the microfabrication processes of a Ruthenium-based resistance temperature detector and its behavior in response to irradiation at ambient temperature. The radiation test was done in a public hospital facility and followed the procedures based on the ESA specification ESCC 22900. The instrumentation system used for the test is detailed in the work describing the sensors resistance evolution before, during, and after the exposure. A total irradiation dose of 43 krad with 36 krad/h dose rate was applied and a subsequent characterization was performed once the Ru sensors were submitted to an 80°C annealing process during a period of 168 h. The experimental measurements have sho…
Diagnostic Performance and Radiation Dose of the EOS System to Image Enchondromatosis: A Phantom Study
2020
Background: Radiation doses and capability of EOS, conventional radiography (CR), and computed tomography (CT) to detect and measure enchondromas in a dedicated five-year-old anthropomorphic phantom were compared. Methods: To simulate enchondromas, minced pieces of chicken bone and cartilage were packed in conventional kitchen plastic foil to create ovoidal/rounded masses and randomly hung on the phantom. The phantom was imaged five times with CR, CT, and EOS, each time changing the number and position of inserts. All images were reviewed by a senior radiologist and a radiology resident. Results: EOS and CR detected all inserts in 4/5 cases (80%), while in one case 1/17 inserts was not seen…
Fogging effect correction of Gafchromic HD-V2 film response for its use in high-dose radiotherapy
2020
GAFChromic® HD-V2 film is a reliable dose measurement device, thin, flexible, inexpensive, simple to use and easy to analyze. The response in terms of net absorbance with respect to absorbed dose was found to be linear in a large dose range, which supports the feasibility of using the film dosimeters in many applications, such as radiotherapy. For its use, a "fogging" effect must be take into account since film response changes with time. To determine a calibration curve valid for any time, fogging effect was investigated for more than 400 days. A correction procedure allows the use of HD-V2 film dosimeters in high-dose radiotheraphy, as brachytherapy, and quality assurance (QA) procedures.
Influence of the simultaneous calibration of multiple ring dosimeters on the individual absorbed dose
2021
Abstract Ring dosimeters for personal dosimetry are calibrated in accredited laboratories following ISO 4037-3 guidelines. The simultaneous irradiation of multiple dosimeters would save time, but has to be carefully studied, since the scattering conditions could change and influence the absorbed dose in nearby dosimeters. Monte Carlo simulations using PENELOPE-2014 were performed to explore the need to increase the uncertainty of H p 0 .07 in the simultaneous irradiation of three and five DXT-RAD 707H-2 (Thermo Scientific) ring dosimeters with beam qualities: N-30, N-80 and N-300. Results show that the absorbed dose in each dosimeter is compatible with each of the others and with the refere…
Response charactterization of ammonium tartrate solid state pellets for ESR dosimetry with radiotherapeutic photon and electron beams.
2001
Solid state pellets (1 mm thick) for electron spin resonance (ESR) dosimetry were made using ammonium tartrate as the radiation-sensitive substance. Their behaviour was experimentally investigated as a function of dose with 60Co gamma rays. The calibration function obtained permits measurements of absorbed dose in the 2-50 Gy range, with a combined uncertainty of +/-4%. The lowest detectable dose was about 0.5 Gy. These properties are comparable with or even better than those of ESR dosimeters made from other materials. The time stability of the ESR signal of ammonium tartrate dosimeters at different storage conditions after irradiation was studied. A rather complex behaviour was observed, …
A Monte Carlo study of intersource effects in dome-type applicators loaded with LDR Cs-137 sources
2005
In this study, the dose rate distributions produced by low dose rate Cs-137 sources loaded in afterloadable dome applicators are studied using the Monte Carlo method. Dose differences between Monte Carlo results and calculations done using the superposition principle are within 1-3% in front of the applicator and between 3 and 10% near and along the longitudinal source axis. Consequently, the real doses to lateral vaginal wall, rectum and bladder are very close to the doses estimated applying the superposition principle, while the dose to the vaginal cuff has been overestimated by up to 10%.
Characterization of the ESR response of alanine dosimeters to low-energy Cu-target X-tube photons
2017
Abstract This article describes Electron Spin Resonance (ESR) response measurements of Kodak BioMax alanine films exposed to low-energy X-rays from a Cu-target tube operating at 20 kV. Commercial alanine detectors were used to ensure maximum reproducibility of the results, while the choice of a film was due the low penetration of the soft X-rays. X-ray energy spectra and fluences were determined with an innovative digital semiconductor detector system. These data were used to quantify the irradiation of the alanine films in terms of absorbed dose to water. The alanine films were found to present a stable response, highly linear with dose. To our knowledge, these data have not been previousl…
Depth-dose measurement corrections for the surface electronic brachytherapy beams of an Esteya® unit: a Monte Carlo study
2020
Abstract Three different correction factors for measurements with the parallel-plate ionization chamber PTW T34013 on the Esteya electronic brachytherapy unit have been investigated. This chamber type is recommended by AAPM TG-253 for depth-dose measurements in the 69.5 kV x-ray beam generated by the Esteya unit. Monte Carlo simulations using the PENELOPE-2018 system were performed to determine the absorbed dose deposited in water and in the chamber sensitive volume at different depths with a Type A uncertainty smaller than 0.1%. Chamber-to-chamber differences have been explored performing measurements using three different chambers. The range of conical applicators available, from 10 to 30…
An EPR method for discriminating radiation beams in ammonium tartrate and tooth enamel
2008
The radiation linear energy transfer (LET), which is the energy released by ionizing radiation per path unit, arouses great scientific interest because the biological damage produced by ionizing radiation in tissues is strictly related to LET. Radiation beams with different LETs will cause different spatial energy distribution and therefore different effects inside matter. In the last twenty years the EPR spectroscopy has become a valuable dosimetric tool. This technique allows absorbed dose measurements through the detection of free radicals produced by ionizing radiation in organic and/or inorganic compounds. In this work we have analyzed the possibility of using the acquisition of two co…