Search results for " EVALUATION"
showing 10 items of 1458 documents
Disability and work: fitness for work judgement.
2006
The role of physicians, in particular those dealing with health promotion in the workplace, takes on a specific meaning in relation to the difficulties that disabled people encounter both in order to reach the workplace and to reconcile their working activity with the difficulties that result from their condition. Observing the data concerning employment of disabled persons in Italy, it becomes dramatically evident that among the disabled subjects of working age only 17% are employed. OBJECTIVE: The objective of the occupational health physician is to recognise the impairment, study the disability and, possibly, eliminate or reduce the handicap. Achieving this target is difficult, and there…
Disseny i desenvolupament d'exams a partir d'eines de web semàntica
2011
La Web Semàntica no és una proposta de futur. És una realitat. Davant del creixement caòtic de recursos i l'absència d'una organització clara del web actual, la web semàntica advoca per classificar, dotar d'estructura i anotar els recursos amb semàntica explícita processable per màquines. En aquest article presentem els resultats d'una investigació realitzada a la Universitat de Múrcia pel grup TECNOMOD i el GITE, que de manera multidisciplinar hem abordat l'aplicació d'un programa semàntic denominat OeLE en una assignatura virtual de la Titulació de Pedagogia. Es va dissenyar un entorn d'avaluació en xarxa compost pel programa OeLE i un sistema de consulta del feedback que OeLE proporciona…
Copolymerization of VDF and HFP in Supercritical Carbon Dioxide: A Robust Approach for Modeling Precipitation and Dispersion Kinetics
2012
A kinetic model is developed for the heterogeneous free-radical copolymerization of vinylidene fluoride and hexafluoropropylene in supercritical CO 2. The model accounts for polymerization in both the dispersed (polymer-rich) phase and in the continuous (polymer-free) supercritical phase, for radical interphase transport, diffusion limitations, and chain-length-dependent termination in the polymer-rich phase. A parameter evaluation strategy is developed and detailed to estimate most of the kinetic parameters a priori while minimizing their evaluation by direct fitting. The resulting model predictions compare favorably with the experimental results of conversion and MWD at varying monomer fe…
Theory of heterogeneous viscoelasticity
2015
We review a new theory of viscoelasticity of a glass-forming viscous liquid near and below the glass transition. In our model we assume that each point in the material has a specific viscosity, which varies randomly in space according to a fluctuating activation free energy. We include a Maxwellian elastic term and assume that the corresponding shear modulus fluctuates as well with the same distribution as that of the activation barriers. The model is solved in coherent-potential approximation (CPA), for which a derivation is given. The theory predicts an Arrhenius-type temperature dependence of the viscosity in the vanishing-frequency limit, independent of the distribution of the activatio…
Revista electrónica de investigación y evaluación educativa
2014
Resumen tomado de la publicación Título, resumen y palabras clave en inglés y español Se muestra el proceso seguido para diseñar e identificar las propiedades psicométricas del instrumento de evaluación del constructo Atención a la Diversidad como variable de contexto. Para ello, se ha comenzado con una pequeña revisión de los instrumentos utilizados para recoger información sobre la diversidad tanto cultural como social, lingüística o en capacidades. A continuación y, partiendo de una clasificación de los distintos enfoques teóricos, se ha construido un primer instrumento, apostando por un enfoque inclusivo. Posteriormente se procede a una validación por expertos. Tras la validación se tom…
The new 5- or 6-azapyrimidine and cyanuric acid derivatives of L-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic space…
2011
Abstract We report on the synthesis of the novel types of cytosine and 5-azacytosine (1–9), uracil and 6-azauracil (13–18) and cyanuric acid (19–22) derivatives of l -ascorbic acid, and on their cytostatic activity evaluation in human malignant tumour cell lines vs. their cytotoxic effects on human normal fibroblasts (WI38). The CD spectra analysis revealed that cytosine (5 and 6), uracil (14–16), 6-azauracil (17) and cyanuric acid (21) derivatives of l -ascorbic acid bearing free amino group at ethylenic spacer existed as a racemic mixture of enantiomers, whereas L-ascorbic derivatives containing the C-5 substituted hydroxy group at the ethylenic spacer were obtained in (4R, 5S) enantiomer…
Chemical composition and antimicrobial activity of the essential oils of some species of Anthemis sect. Anthemis (Asteraceae) from Sicily
2017
The chemical composition of the essential oils isolated from the aerial parts of Anthemis arvensis L. subsp. arvensis, Anthemis cretica subsp. messanensis (Brullo) Giardina & Raimondo and from flowers and leaves of Anthemis cretica subsp. columnae (Ten.) Frezén were determinated by GC–FID and GC–MS analyses. Torreyol (85.4%) was recognised as the main constituent of the Anthemis arvensis subsp. arvensis essential oil, while in the essential oils of Anthemis cretica subsp. messanensis, collected on the rock and cultivated in Hortus Botanicus Panormitanus, (E)-chrysanthenyl acetate (28.8 and 24.2% resp.), 14-hydroxy-α-humulene (8.1 and 5.3% resp.), santolina triene (8 and 5.8% resp.) and …
New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors.
2008
Bond-based quadratic indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis (LDA) were used to discover novel lead trichomonacidals. The obtained LDA-based quantitative structure-activity relationships (QSAR) models, using nonstochastic and stochastic indices, were able to classify correctly 87.91% (87.50%) and 89.01% (84.38%) of the chemicals in training (test) sets, respectively. They showed large Matthews correlation coefficients of 0.75 (0.71) and 0.78 (0.65) for the training (test) sets, correspondingly. Later, both models were applied to the virtual screening of 21 chemicals to find new lead antitrichomonal agents. Predictions agreed with experimental resu…
Preclinical evidence of new opioid modulators for the treatment of addiction.
2010
Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects. New pharmacological compounds are necessary to improve the outcome of treatments and reduce adverse side effects. Moreover, drugs that act on the opioid system can also be of benefit in the treatment of alcohol or cocaine addiction. AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date).The reader will be informed of the latest drugs shown in animal models to modify dependence on opiates and the reinforcing…
Covalent binding of drug metabolites to DNA ? a tool of predictive value?
1980
The presently available data suggest at least some correlation between covalent binding of drug metabolites to DNA and carcinogenicity of that drug. More data, however, are needed to establish the predictability of covalent DNA binding assays for extrahepatic cancer. A covalent binding assay requires administration of radioactively labelled compound to the experimental animals; the availability of labelled compound and requirements as to radiochemical purity, chemical and biochemical stability are limiting the applicability of this procedure. Many technical pitfalls accompany covalent DNA binding assays. It is concluded that at the present time DNA binding assays do not represent routine pr…