Search results for " Emission"
showing 10 items of 1496 documents
The DAT ligand [(18)F]PR17.MZ mirrors the in vivo pharmacokinetic profile of [(11)C]cocaine with significantly improved monoamine transporter selecti…
2010
(18) F-labeled folic acid derivatives for imaging of the folate receptor via positron emission tomography.
2013
The folate receptor (FR) is already known as a proven target in diagnostics and therapy of cancer. Furthermore, the FR is involved in inflammatory and autoimmune diseases. The major advantage as a valuable target is its strongly limited expression in healthy tissues. Over the past two decades, several folic acid-based radiopharmaceuticals addressing the FR have been developed, and some of them show great potential for applications in clinical routine. However, most of these radiofolates were developed for single photon emission computed tomography imaging, and only a few can be used for positron emission tomography (PET) imaging. The development of suitable (18) F-labeled derivatives for PE…
Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide
2011
4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield.
Performance evaluation of a high resolution dedicated breast PET scanner
2016
Purpose: Early stage breast cancers may not be visible on a whole-body PET scan. To overcome whole-body PET limitations, several dedicated breast positron emission tomography (DbPET) systems have emerged nowadays aiming to improve spatial resolution. In this work the authors evaluate the performance of a high resolution dedicated breast PET scanner (Mammi-PET, Oncovision). Methods: Global status, uniformity, sensitivity, energy, and spatial resolution were measured. Spheres of different sizes (2.5, 4, 5, and 6 mm diameter) and various 18 fluorodeoxyglucose (18F-FDG) activity concentrations were randomly inserted in a gelatine breast phantom developed at our institution. Several lesion-to-ba…
Hyaluronan-Based Graft Copolymers Bearing Aggregation-Induced Emission Flurogens
2017
In order to develop a technology platform based on two natural compounds from biorenewable resources, a short series of hyaluronan (HA) copolymers grafted with propargylated ferulic acid (HA-FA-Pg) were designed and synthesized to show different grafting degree values and their optical properties were characterized in comparison with reference compounds containing the same ferulate fluorophore. Interestingly, these studies revealed that the ferulate fluorophore was quite sensitive to the restriction of intramolecular motion and its introduction into the rigid HA backbone, as in HA-FA-Pg graft copolymers, led to higher photoluminescence quantum yield values than those obtained with the isola…
Development of Trackable Anticancer Agents Based on Metal Complexes
2016
Abstract The design of trackable anticancer agents is of major interest for the future development of therapeutics based on nonplatinum metal complexes such as Ru(II), Os(II), or Au(I) derivatives, and more particularly for the understanding of the mechanism of action of these metal-based drugs. This review reports the synthesis and the first biological studies of original trackable complexes, in which the metal complex was coupled to an imaging probe, such as a fluorophore (coumarin, borodipyrromethene derivative (BODIPY), porphyrin), or a chelating agent (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)) for radioisotopic imaging PET (positron emission tomography) or SPECT …
REMOTE SENSING ANALYSIS COUPLED TO FIELD MEASUREMENTS FOR THE EVALUATION OF METHANE EMISSIONS FROM A LANDFILL SITE: A CASE STUDY
2015
SUMMARY: the waste disposal in sanitary landfills generates landfill gas (LFG), mainly constituted by methane (CH4) and carbon dioxide (CO2), because of the anaerobic degradation of the organic matter contained in the disposed waste. It is worth mentioning that CH4 is recognized as one of the most important contributor to global warming and sanitary landfills for Municipal Solid Waste (MSW) have been found to be a significant source of CH4 generation and emission. The main aim of the present work was the evaluation of methane emissions from a Sicilian landfill site by coupling of direct field measurements and ground temperature data acquired through remote sensing techniques. It is worth me…
Development of a Model to Estimate the Risk of Emission of Greenhouse Gases from Forest Fires
2022
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Quantum chemical modelling of electron polarons and green luminescence in PbTiO3perovskite crystals
2002
In an extension of our previous study on the electron polarons and excitons in KNbO3, KTaO3 and BaTiO3 (Kotomin E A, Eglitis R I and Borstel G 2000 J. Phys. Condens. Matter 12 L557; Eglitis R I, Kotomin E A and Borstel G 2002 J. Phys. Condens. Matter 14 3735) by the semiempirical Hartree–Fock method we present here results for free electron polarons in the PbTiO3 perovskite crystal. We discuss the origin of the intrinsic visible band emission of PbTiO3 perovskite oxides (so-called 'green luminescence') which has remained a topic of high interest during the last quarter of a century. We present a theoretical calculation modelling this emission in the framework of a concept of charge transfer…
Controlling laser assisted radiative recombination with few-cycle laser pulses
2006
We report on the radiative recombination of a free electron with a hydrogenic ion in the presence of a few-cycle pulses. It has been shown that the main features of the emission spectra may be described in the framework of a semiclassical model in which the recombination is viewed as a two-step process. The spectra width of the emitted photon energy is practically confined in a range of values in which the emission is classically allowed. Moreover, it has been found that spectra width can be controlled by varying the carrier envelope phase and/or the pulse peak intensity.