Search results for " Ep"
showing 10 items of 3258 documents
Odorant Metabolism Analysis by an Automated Ex Vivo Headspace Gas-Chromatography Method
2015
International audience; In the olfactory epithelium (OE), odorant metabolizing enzymes have the dual function of volatile component detoxification and active clearance of odorants from the perireceptor environment to respectively maintain the integrity of the tissues and the sensitivity of the detection. Although emphasized by recent studies, this enzymatic mechanism is poorly documented in mammals. Thus, olfactory metabolism has been characterized mainly in vitro and for a limited number of odorants. The automated ex vivo headspace gas-chromatography method that was developed here was validated to account for odorant olfactory metabolism. This method easily permits the measurement of the f…
Role of Ocular Angiogenic Factors in the Development of Neovascular Age-Related Macular Degeneration
2020
Abstract Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of AMD characterised by abnormal growth of newly formed blood vessels in chorioidea which typically involves fluid accumulation in the retina or retinal haemorrhage, retinal epithelial detachments, hard exudate or subretinal scars. The process of angiogenesis is controlled by ocular angiogenic factors, which have enabled the development of different treatment options aimed at these factors. This review aims to compile the available information about the most commonly identified ocular angiogenic factors, uncovering their role in …
Oxidation-Induced Increase In Photoreactivity of Bovine Retinal Lipid Extract
2017
Open access original paper Source : 10th EPR Workshop on Applications of EPR in Biology and Medicine, 2016 in Krakow, POLAND.; International audience; The mammalian retina contains a high level of polyunsaturated fatty acids, including docosahexaenoic acid (22:6) (DHA), which are highly susceptible to oxidation. It has been shown that one of the products of DHA oxidation-carboxyethylpyrrole (CEP), generated in situ, causes modifications of retinal proteins and induces inflammation response in the outer retina. These contributing factors may play a role in the development of age-related macular degeneration (AMD). It is also possible that some of the lipid oxidation products are photoreactiv…
Comparative validity of the ASSO - Food Frequency Questionnaire for the web-based assessment of food and nutrients intake in adolescents
2015
Background : A new web-based food frequency questionnaire (the ASSO–FFQ) was developed within the ASSO Project funded by the Italian Ministry of Health. Objective : The aim of the present study is to assess the validity of the ASSO–FFQ at food groups, energy, and nutrients level. Design and subjects : The validation study compared the ASSO–FFQ against a weighted food record (WFR) measuring foods, beverages and supplements intake, compiled during the week following the ASSO–FFQ administration. Ninety-two subjects aged 14–17, recruited from secondary schools in Palermo (Italy), completed the ASSO–FFQ and WFR. The intake of 24 food groups, energy, and 52 nutrients were taken as main outcomes. …
Did you hear? Auditory prospective memory cues are more beneficial for autistic than for non-autistic children and adolescents
2021
Item does not contain fulltext Background: The transition from primary to secondary school is particularly difficult for autistic children, a transition underpinned by an increase in prospective memory (PM) demands. Aims: To better understand PM in autistic children of the relevant age range and its underlying processes, the current study investigated the impact of cue salience (distinctiveness) on PM in autistic and non-autistic children and adolescents. The study was unique in manipulating the visual and auditory salience of PM cues. Salient cues are assumed to put lower demands on executive control resources as compared to cues that blend in with the ongoing activity. Methods and procedu…
Assessment of genetically modified sugar beet H7‐1 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐006)
2017
Efsa Panel On Genetically Modified Organisms (gmo)Scientific opinionRequestor: European Commission (DG SANTE)Question number: EFSA-Q-2017-00026; Following the submission of application EFSA-GMO-RX-006 under Regulation (EC) No 1829/2003 fromKWS SAAT SE and Monsanto Company, the Panel on Genetically Modified Organisms of the EuropeanFood Safety Authority (GMO Panel) was asked to deliver a scientific risk assessment on the datasubmitted in the context of the renewal of authorisation application for the herbicide-tolerantgenetically modified sugar beet H7-1. The data received in the context of this renewal applicationcontained a systematic search and evaluation of literature, updated bioinforma…
Ficciones inmunitarias. Sobre la lógica de la inmunidad en la cultura contemporánea
2018
This article develops the concept of “immunitarian fiction” taking as paradigmatic examples epidemics and zombie narratives, which share the idea of contagion as the main matrix of their narrative. The article tries to address the following question: in what way do these fictions, and other similar ones, participate in the imaginary of immunity and, at the same time, show some of their internal contradictions? For this, the text reflects on a set of cultural products of mass diffusion (novels, television series, cinematographic works). We analyze, in the first place, how these fictions highlight the fears and social anxieties linked to the tensions of the “immune paradigm” and represent the…
"In der Mathematik ist ein Streit mit Sicherheit zu entscheiden". Perspektiven einer Soziologie der Mathematik
2000
Die Mathematik wird in diesem Aufsatz als ein empirisches Beispiel präsentiert, an dem sich die Voraussetzungen eines "rationalen Dissenses" exemplarisch untersuchen lassen. Denn im Gegensatz zu anderen epistemischen Kulturen gibt es in der Mathematik weder interpretative Flexibilität noch unentscheidbare Kontroversen. Auf der Basis einer medientheoretischen Perspektive und einer Feldstudie in einem internationalen Mathematikinstitut geht der Aufsatz der Frage nach, ob die Soziologie im Falle der Mathematik nicht auf eine prinzipielle Grenze stößt. In einem ersten Teil wird die These einer epistemischen Besonderheit der Mathematik präzisiert und in Auseinandersetzung mit zwei programmatisch…
DE PRESSUPOSTOS SOBRE O CONHECIMENTO E A APRENDIZAGEM À PRÁXIS NA FORMAÇÃO DO TRADUTOR
2016
Este artigo discute o problema da ausência de programas acadêmicos de qualificação para professores de tradução que têm de recorrer às suas próprias intuições e à abordagem pedagógica popular. Objetiva identificar os entendimentos subjacentes da natureza do conhecimento e da aprendizagem que estão por trás da tradicional prática de ensino do “Quem quer vai fazer a primeira sentença?”, bem como das abordagens didáticas alternativas. Embora existam algumas publicações inspiradoras e motivadoras sobre metodologias inovadoras de ensino centradas no aluno, estas ainda carecem de discussões sobre a epistemologia pedagógica ou quaisquer princípios gerais ou teoria da educação. A principal tese pro…
Can copper(II) mediate Hoogsteen base-pairing in a left-handed DNA duplex? A pulse EPR study
2010
Pulse EPR spectroscopy is sued to investigate possible structural features of the copper(II) ion coordinated to poly(dG-dC) poly(dG-dC) in a frozen aqueous solution, and the structural change of the polynucleotide induced by the presence of the metal ion. Two different copper species were identified and their geometry explained by a molecular model. According to this model, one species is exclusively coordinated to a single guanine with the N7 nitrogen atom forming a coordinative bond with the copper. In the other species, a guanine and a cytosine form a ternary complex together with the copper ion. A copper crosslink between the N7 of guanine and N3 of cytosine is proposed as the most prob…