Search results for " FORMS"

showing 10 items of 199 documents

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Ondansetron.

2019

Literature data pertaining to the physicochemical, pharmaceutical, and pharmacokinetic properties of ondansetron hydrochloride dihydrate are reviewed to arrive at a decision on whether a marketing authorization of an immediate release (IR) solid oral dosage form can be approved based on a Biopharmaceutics Classification System (BCS)-based biowaiver. Ondansetron, a 5HT3 receptor antagonist, is used at doses ranging from 4 mg to 24 mg in the management of nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative treatment. It is a weak base and thus exhibits pH-dependent solubility. However, it is able to meet the criteria of "high solubility" as well as "high permeabi…

NauseaPharmaceutical ScienceAdministration OralBiological Availabilitydissolution02 engineering and technologyBioequivalencePharmacology030226 pharmacology & pharmacyDosage formBiopharmaceuticsOndansetronExcipients03 medical and health sciencesondansetron hydrochloride dihydrate0302 clinical medicinePharmacokineticsMedicineHumansDissolution testingDosage FormsOndansetron hydrochloridebusiness.industrybiopharmaceutics classification system (BCS)solubility021001 nanoscience & nanotechnologyBiopharmaceutics Classification SystemOndansetronbiowaiverTherapeutic Equivalencymedicine.symptompermeability0210 nano-technologybusinessmedicine.drugTablets
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New Families as an Educational Emergency

2017

One phenomenon typical of late-modern Western societies is the extreme pluralisation of family forms, a true and proper archipelago of families, so that: the family can no longer be reasonably discussed in the singular, just as well as each couple seems to form a «mixed couple» . Observing the data describing this phenomenon and any perceived trends, prompt a first general consideration, from an educational perspective: the aspects related to couple formation, the choice of whether to marry, the preferred family forms, all highlight a breakup between the older and the younger generations. In short, we are confronted with a new culture of human relationships: this new culture sets new symbol…

New couple relationships New family forms The couple's being a couple From couple to family The family's being a family The family as an existential The right to an aeducational safeguardSettore M-PED/01 - Pedagogia Generale E Sociale
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Prefazione

2014

In un contesto in continua evoluzione per effetto della globalizzazione e della rivoluzione tecnologica, la definizione del concetto di devianza e l’esplorazione dei suoi cambiamenti rendono necessaria una riflessione trasversale a diversi ambiti disciplinari, attraversando il confine tra sociologia della devianza e diritto. In a changing environment as a result of globalization and technological revolution, the definition of the concept of deviance and the exploration of its changes make necessary a cross-reflection in different disciplines, crossing the border between sociology of deviance and law.

New forms of deviance Internet and control digital nativesSettore SPS/11 - Sociologia Dei Fenomeni PoliticiSettore SPS/12 - Sociologia Giuridica Della Devianza E Mutamento SocialeNuove forme di devianza Internet e controllo nativi digitali
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Viaggi nell’immaginario: il turismo virtuale nel sito UNESCO di Tarragona

2023

Le nuove tecnologie hanno trasformato in modo radicale non solo la geografia come disciplina, ma anche le geografie del mondo. Il digitale ha assunto, infatti, un ruolo di mediazione sempre più pervasivo nella produzione dello spazio, come delle conoscenze e degli immaginari geografici. Le possibilità offerte dal virtuale, in particolare, offrono oggi un contributo decisivo nella comunicazione dei significati attribuiti ai luoghi e rispondono in modo sempre più efficace ai bisogni emergenti del settore turistico. Le esperienze di visita mediate dal digitale mirano a coinvolgere i sensi e risultano efficaci quando promuovono immersioni rigorosamente realistiche. Nel quadro di queste riflessi…

New technologies have radically transformed not only geography as a discipline but also the geographies of the world. Indeed the digital has assumed an increasingly pervasive mediating role in the production of space as of geographic knowledge and imaginaries. The possibilities offered by the virtual in particular now offer a decisive contribution in communicating the meanings attributed to places and respond increasingly effectively to the emerging needs of the tourism sector. Digitally mediated visitor experiences aim to engage the senses and are effective when they promote rigorously realistic immersions. Within the framework of these reflections the paper highlights the renewed relevance of authenticity both of the tourism experience and of cultural heritage in relation to its potential for attraction and proposes a contextualization of the theme in light of the unprecedented opportunities granted by technologies for the creation of virtual and augmented spaces. The proposed discussion is therefore also a journey aimed at exploring authenticity as a tool through which new technologies can effectively mediate a sense of place and foster brand communication of a destination. The case study is the UNESCO site of Tarragona whose most relevant image for urban policies is presented. This shared figuration spatially defined and rooted in a precise historical moment is reconstructed on the one hand through the analysis of functional documentation for the candidacy and on the other by means of a review of mobile applications developed for the promotion of the city's cultural heritage. The proposed journey and exploration of the place return in light of the research data and in conclusion the central role played by digital technologies in mediating the UNESCO imaginary. The forms of virtual tourism in Tarragona confirm that to travel is to experience a text enveloped in time and inscribed in space.Settore M-GGR/01 - Geografia
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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A survey on solvable sesquilinear forms

2018

The aim of this paper is to present a unified theory of many Kato type representation theorems in terms of solvable forms on a Hilbert space \((H,\langle\cdot,\cdot\rangle)\) In particular, for some sesquilinear forms Ω on a dense domain \(D\subseteq\mathcal {H}\) one looks for a representation \(\Omega(\xi,\eta)= \langle T\xi,\eta\rangle\) \((\xi\epsilon\mathcal{D}\mathcal(T),\eta\epsilon D)\) where T is a densely defined closed operator with domain \(D(\mathcal{T})\subseteq \mathcal{D}\). There are two characteristic aspects of a solvable form on H. One is that the domain of the form can be turned into a reexive Banach space that need not be a Hilbert space. The second one is that represe…

Operator (physics)Banach spaceHilbert spaceKato’s representation theoremType (model theory)Combinatoricssymbols.namesakeSettore MAT/05 - Analisi MatematicaProduct (mathematics)Bounded functionDomain (ring theory)symbolsQ-closed and solvable sesquilinear formsUnified field theoryMathematics
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Actuality of Art Education at the Beginning of XX Century in East Europe. Graphic Constructions Through Gestaltung and Formenlehre in Figurative Crea…

2018

The great innovations in the field of the elaboration of forms and figures in the last century have often sometimes accompanied the amazement and optimism of the discovery, a methodological uncertainty shared with other fields of Knowledge. It is undeniable that the advent of information technology and representation—together with the socio-economic changes that have taken place—has laid the foundations for an irreversible ontological leap in the process of form processing, and yet very often there are references historians that can somehow inspire current theories and practices. In this sense, some interpretations considered to be classical, from Valery to Benjamin, from Arnheim to Waburg,…

PaintingSculptureTheory of Formsmedia_common.quotation_subjectField (Bourdieu)ArtLiteral and figurative languageThe artsGestaltung Proun formenlehre teaching of figurative creativitiesVisual arts educationAestheticsSettore ICAR/17 - DisegnoComposition (language)media_common
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Identification of Distributed Systems with Logical Interaction Structure

2012

This paper focuses on the structure identification problem for a class of networked systems, where the interaction among components or agents is described through logical maps. In particular, agents are heterogeneous cooperating systems, i.e. they may have different individual dynamics and different interaction rules depending on input events. While we assume that the individual agents' dynamics are known, each agent has partial knowledge of the logical map encoding the interaction of another agent with its neighbors. Based on the so-called algebraic normal form for binary functions, we present a technique by which the network structure described by a logical function can be dynamically est…

Partial knowledgeTheoretical computer scienceInteraction ruleDistributed computingBinary numberClass (philosophy)Individual dynamicAlgebraic normal formLogical functionAlgebraic normal forms; Binary functions; Cooperating systems; Distributed systems; Individual agent; Individual dynamics; Interaction rules; Interaction structures; Logical functions; Logical maps; Lower approximation; Network structures; Networked systems; Partial knowledge; Real systems; Structure identification; Truth tablesBinary functionSettore ING-INF/04 - AutomaticaLogical mapMathematicsCooperating systemStructure (mathematical logic)Networked systemStructure identificationTruth tablesTruth tableMobile robotReal systemParameter identification problemAlgebraic normal formIdentification (information)Lower approximationInteraction structureIndividual agentDistributed systemNetwork structure
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Object, Structure, and Form

2012

The main task of this paper is to develop the non-Platonist view of mathematics as a science of structures I have called, borrowing the label from Putnam, `realism with the human face'. According to this view, if by `object' we mean what exists independently of whether we are thinking about it or not, mathematics is a science of patterns (structures), where patterns are neither objects nor properties of objects, but aspects (or aspects of aspects, etc.) of concrete objects which dawn on us when we represent objects (or aspects of... within a given system (of representation). Mathematical patterns, therefore, are real, because they ultimately depend on concrete objects, but are neither objec…

Patterns Mathematical structuralism Abstract objects Forms of representation Systems of representation RealismSettore M-FIL/02 - Logica E Filosofia Della Scienza
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Simultaneous dissolution profiles of two drugs, sulfadiazine-trimethoprim and amitriptyline-perphenazine, in solid oral dosage forms by a FIA manifol…

2002

The simultaneous determination of two dissolution profiles with the aid of a Flow Injection Analysis assembly has been applied to: (a) sulfadiazine-trimethoprim in tablets and (b) amitriptyline-perphenazine in sugar coated pills. The selected combinations are drugs which have overlapping UV-vis spectra. The officially proposed procedure from the pharmacopoeias has been adapted for the FIA methodology and derivative spectrophotometry and zero crossing. Preliminary experiments on the suitability of the simultaneous determination of both drugs were performed. The empirical profiles were adjusted by regression analysis using different approaches. The 3-parameter plot method was finally selected…

PerphenazineAmitriptylineClinical BiochemistryAnalytical chemistryAdministration OralSulfadiazinePharmaceutical ScienceDerivativeTrimethoprimDosage formAnalytical ChemistrySpectrophotometryDrug DiscoverymedicineDissolutionSpectroscopyDosage FormsFlow injection analysisAmitriptyline/perphenazineChromatographymedicine.diagnostic_testChemistryDetectorDrug CombinationsSolubilitySpectrophotometryFlow Injection AnalysisPerphenazinemedicine.drugJournal of Pharmaceutical and Biomedical Analysis
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