Search results for " Farm"

Estudios de polimorfismos genéticos TNF-alfa (238 y 308), IL-10 (1082), MTHFR (677) y del DAS-28, como predictores de la respuesta al tratamiento con…

2009

La importancia de la artritis reumatoide como enfermedad crónica y progresiva, prevalente e incapacitante, plantea el problema de establecer un tratamiento efectivo y precoz para ralentizar en lo posible el curso de la enfermedad y evitar la utilización de medicamentos innecesarios teniendo en cuenta que los medicamentos biológicos de última generación no están exentos de reacciones adversas importantes.En este trabajo se aborda la capacidad de los polimorfismos en los genes del TNF-alfa en las posiciones 238 y 308, de la Interleukina-10 en la posición 1082, de gen de la metilen-tetra-hidro-folato-reductasa (MTHFR) en la posición 677, así como del indicador DAS28 como predictores de la resp…

Estudio del factor de transcripción SREBP1 en estados de resistencia a insulina

2007

Tesis doctoral del Departamento de Bioquímica y Biología Molecular

Estudio de reacciones de acoplamiento en [1,2,3]triazolo[1,5-a]piridinas. Ariltriazolopiridinas.

2006

En las últimas décadas han surgido una gran cantidad de métodos catalíticos para formar biarilos a partir de precursores monoarilos. La formación de enlaces carbono-carbono vía acoplamiento de reactivos organometálicos con haluros orgánicos o triflatos catalizado por metales de transición se ha convertido en una importante metodología de síntesis. En la actualidad, las reacciones de acoplamiento cruzado (cross-coupling), son una estrategia ampliamente generalizada para la obtención de sistemas de tipo biarilo. En el caso de las triazolopiridinas no existían ejemplos de reacciones de acoplamiento. Basándonos en la literatura descrita se decidió la aplicación de las metodologías de acoplamien…

Coherence in ultrashort light pulses and applications in temporal optics.

2008

In the last decades, the generation of lasers delivering pulses with durations in the order of femtosecond has constituted an important research topic for the Physics and Engineering communities. The characteristics of this kind of radiation, i.e., broadband spectrum, enormous temporal resolution, high peak-power with low energy average, potentially high repetition rate and high spatial coherence make it an indispensable tool in order to develop many applications in different fields of science and technology. Ultrafast laser technology is ready to offer real world applications ranging from high-tech, such us high-speed circuit testing and biological imaging, to more industrial applications …

Synthesis and antitumor activity of new 7-azaindole derivative nortopsentin analogues

2016

Formulative and stability studies of a Citrus extract to produce novel “healthy food"

2015

Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents

2022

Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance …

Ceiba speciosa (A. St.-Hil.) Seeds Oil: Fatty Acids Profiling by GC-MS and NMR and Bioactivity

2020

This study aimed to evaluate the chemical composition by gas chromatography-mass spectrometry (GC-MS) and Nuclear Magnetic Resonance (NMR) analyses, the antioxidant activities evaluated by different in vitro assays namely 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2&prime

Adipokines in obesity and metabolic diseases

2020

Adipose tissue secretes many adipokines that regulate important physiological functions. Growing studies have highlighted that these bioactive molecules may contribute to the development of metabolic and cardiovascular diseases. Adipokines exert systemic metabolic effects and independent activity on numerous cells of the cardiovascular system, including cardiomyocytes and vascular cell walls. Adiponectin shows anti-inflammatory and anti-atherosclerotic activity on blood vessels. Conversely, resistin is endowed with pro-inflammatory effects and stimulates the proliferation of smooth muscle cells, thus promoting the development of atherosclerotic plaque. Leptin plays an important role in card…

Ferulago nodosa Subsp. geniculata (Guss.) Troia & Raimondo from Sicily (Italy): Isolation of Essential Oil and Evaluation of Its Bioactivity

2020

Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area. The object of the present study is Sicilian F. nodosa subsp. geniculata (Guss.) Troia & Raimondo, classified as an endemic F. nodosa subspecies. Aerial parts of this plant species were subjected to hydrodistillation to obtain an essential oil. A total of 93 compounds were identified with 2,3,6-trimethyl benzaldehyde (19.0%), spathulenol (9.0%), (E)-caryophyllene (5.4%), and caryophyllene oxide (5.4%) as the main components. The biological activities of F. nodosa essential oil were also investigated. This oil showed an interesting antioxidant potential in a 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sul…