Search results for " Farm"
showing 10 items of 2009 documents
STATISTICAL ANALYSIS OF A SURVEY ABOUT DIFFUSION OF BINGE DRINKING AND DRUNKOREXIA AMONG YOUNG PEOPLE
2017
Youth alcohol consumption is a major global public health concern. Previous reviews have concluded that exposure to alcohol marketing was associated with drinking initiation and higher alcohol consumption among youth. From January to May 2017, a survey has been conducted through administration of questionnaires about the diffusion of binge drinking and drunkorexia among the students of Palermo. Test was administered, during school time, to 2331 students between the ages of 13 and 20. Regarding the analysis of the questionnaires, 97.8% of student declare to have drunk at least once: their first taste of alcoholic drink happens at the age of thirteen/fourteen. They prefer to drink at the disc…
The Agr communication system provides a benefit to the populations of Listeria monocytogenes in soil
2014
International audience; In this study, we investigated whether the Agr communication system of the pathogenic bacterium Listeria monocytogenes was involved in adaptation and competitiveness in soil. Alteration of the ability to communicate, either by deletion of the gene coding the response regulator AgrA (response-negative mutant) or the signal pro-peptide AgrD (signal-negative mutant), did not affect population dynamics in soil that had been sterilized but survival was altered in biotic soil suggesting that the Agr system of L. monocytogenes was involved to face the complex soil biotic environment. This was confirmed by a set of co-incubation experiments. The fitness of the response-negat…
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
2022
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity. This research was funded by the National Na…
The widespread presence of a family of fish virulence plasmids in Vibrio vulnificus stresses its relevance as a zoonotic pathogen linked to fish farms
2021
Vibrio vulnificus is a pathogen of public health concern that causes either primary septicemia after ingestion of raw shellfish or secondary septicemia after wound exposure to seawater. In consequence, shellfish and seawater are considered its main reservoirs. However, there is one aspect of its biology that is systematically overlooked: its association with fish in its natural environment. This association led in 1975 to the emergence of a zoonotic clade within phylogenetic lineage 2 following successive outbreaks of vibriosis in farmed eels. Although this clade is now worldwide distributed, no new zoonotic clades were subsequently reported. In this work, we have performed phylogenetic, ge…
Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention.
2018
Nowadays, chemoprevention by administering natural supplements is considered an attractive strategy to reverse, suppress, or prevent the evolution of premalignant oral lesions. In particular, Barbaloin exhibits anti-proliferative, anti-inflammatory, and anti-cancer properties, and it results useful in multi-therapy with classic chemotherapeutics. Therefore, in this work, mucoadhesive buccal films, as locoregional drug delivery system able to provide a targeted and efficient therapeutic delivery of Barbaloin, are proposed. Thus, Aloin extract-loaded Eudragit (R) RL100 or Eudragit (R) RS100-based buccal films were designed in order to obtain an easily self-administrable formulation capable of…
Docking of indolo- and pyrrolo-pyrimidines to DNA. New DNA-interactive polycycles from amino-indoles/pyrroles and BMMA
2004
New indolo- and pyrrolo-pyrimidines of type 1-4 were studied for their ability to form stable complexes with DNA fragments. The calculated free energies of binding were found in the range -8.39 ÷ -16.72 Kcal/mol. The docking studies revealed a common binding mode with the chromophore intercalated between GC base pairs whereas the side chain lies along the minor groove.
Impact of Legislative Changes on the Availability of Medicines and Pharmacovigilance Activities
2021
Zāļu pieejamība ir vispārējas cilvēktiesības, tomēr tā joprojām saglabājas globāla problēma. Šajā pētījumā par objektu izvēlēts Latvijas lielākās kaimiņvalsts – Krievijas Federācijas (KF) – zāļu normatīvais regulējums, kurā 2010. gadā notika radikālas izmaiņas, kas noveda pie papildu administratīvā sloga un ietekmes uz zāļu pieejamību un farmakovigilances aktivitātēm. Tā kā Latvijas farmaceitiskajiem uzņēmumiem un citu Eiropas Savienības (ES) valstu zāļu ražotājiem KF tirgus ir nozīmīgs, tiem būtu noderīgi iegūt zinātnisku ieskatu zāļu reģistrāciju regulējošos procesos kas palīdzētu uzlabot to darbību. Pētījums ir nozīmīgs arī valsts iestāžu darbiniekiem, lai paredzētu sekas un plānotu norm…
Pharmacophore modeling e screening in silico di nuovi inibitori della proteina antiapoptotica Bcl-xl
2008
Synthesis, antiproliferative activity, and mechanism of action of new benzamido derivatives
2011
The cinnamoyl anthranilamides represent a class of biological active substances of great importance in medicinal chemistry. Moreover, despite their wide range of biological activities, a review of the literature revealed that no anticancer activity is described for this kind of substances. Starting from the 2-cinnamamido-5-iodobenzamide, resulted able to inhibit the leukemic cell line K-562 proliferation with a percent of inhibition of 74% at 10M concentration, we undertake the following structural modifications on cinnamamidobenzamide skeleton: the introduction of various substituents both on the benzamido and the cinnamamido moieties, the substitution of olefinic bond with the ethane, et…
Vitrectomía enzimática por inyección intravítrea de plasmina autóloga como tratamiento inicial del edema macular diabético difuso
2008
espanolObjetivo: Determinar si la inyeccion intravitrea de plasmina es efectiva en el tratamiento del edema macular diabetico difuso (EMDD). Diseno: Estudio piloto prospectivo, comparativo, de intervencion, serie de casos. Pacientes: Dieciocho pacientes con edema macular diabetico bilateral, recibieron como primera actuacion terapeutica una inyeccion intravitrea de plasmina en un ojo, sirviendo el ojo contralateral como control. Tratamiento: Inyeccion intravitrea de 0,2 ml de plasmina autologa bajo anestesia topica. La plasmina fue obtenida por un metodo simplificado. Principales medidas: Engrosamiento macular central (EMC) medido por tomografia de coherencia optica (OCT) y agudeza visual (…