Search results for " Formation"

Groupe de travail sur l'analyse régionale de la relation formation-emploi : problématiques et méthodes

1990

International audience; Depuis une vingtaine d'années, et plus encore depuis la mise en place de la décentralisation, des systèmes d'aide à la décision sont demandés par les décideurs régionaux et locaux en matière de formation initiale et continue. Pour tirer les leçons des expériences passées et formuler des propositions pour le développement des observatoires régionaux de l'emploi et de la formation, prévus dans le cadre des contrats de Plan Etat - Région, le C.E.R.E.Q. a pris l'initiative de réunir un groupe de travail, dont les premières réflexions sont relatées ici. Il insiste particulièrement sur la prise en compte de l'évolution socio-économique des comportements et des stratégies d…

La didactique clinique : un champ scientifique pour analyser les pratiques de formation

2023

The transmembrane receptor Uncoordinated5 (Unc5) is essential for heart lumen formation in Drosophila melanogaster

2011

AbstractTransport of liquids or gases in biological tubes is fundamental for many physiological processes. Our knowledge on how tubular organs are formed during organogenesis and tissue remodeling has increased dramatically during the last decade. Studies on different animal systems have helped to unravel some of the molecular mechanisms underlying tubulogenesis. Tube architecture varies dramatically in different organs and different species, ranging from tubes formed by several cells constituting the cross section, tubes formed by single cells wrapping an internal luminal space or tubes that are formed within a cell. Some tubes display branching whereas others remain linear without interse…

Mass Accretion Processes in Young Stellar Objects: Role of Intense Flaring Activity

2014

According to the magnetospheric accretion scenario, young low-mass stars are surrounded by circumstellar disks which they interact with through accretion of mass. The accretion builds up the star to its final mass and is also believed to power the mass outflows, which may in turn have a significant role in removing the excess angular momentum from the star-disk system. Although the process of mass accretion is a critical aspect of star formation, some of its mechanisms are still to be fully understood. On the other hand, strong flaring activity is a common feature of young stellar objects (YSOs). In the Sun, such events give rise to perturbations of the interplanetary medium. Similar but mo…

Angular Pseudomomentum Theory for the Generalized Nonlinear Schr\"{o}dinger Equation in Discrete Rotational Symmetry Media

2009

We develop a complete mathematical theory for the symmetrical solutions of the generalized nonlinear Schr\"odinger equation based on the new concept of angular pseudomomentum. We consider the symmetric solitons of a generalized nonlinear Schr\"odinger equation with a nonlinearity depending on the modulus of the field. We provide a rigorous proof of a set of mathematical results justifying that these solitons can be classified according to the irreducible representations of a discrete group. Then we extend this theory to non-stationary solutions and study the relationship between angular momentum and pseudomomentum. We illustrate these theoretical results with numerical examples. Finally, we…

Factors influencing the interaction of herpes simplex virus glycoprotein C with the third component of complement.

1992

The factors influencing the interaction of herpes simplex virus (HSV) glycoprotein C (gC) with the third component of complement (C3) were investigated in this study. The ability of gC of HSV type 1 (gC-1) to bind to the C3b fragment of C3 was found to be influenced by cell specific processing of gC-1 in a different manner, binding being remarkably enhanced in some cell lines following removal of sialic acid residues. Testing several intertypic recombinants of HSV we found that only strains expressing gC-1 exhibited binding to C3b, even though their genome consisted mainly of HSV-2 sequences in some recombinants. Expression of type-2 glycoproteins gB, gD, gE, gG, gH, and gI did not alter th…

De nouveaux acteurs en EPS : les personnels venus de la Jeunesse et des Sports (1964-fin des années 70)

2015

National audience; L'article s'intéresse aux profils et aux actions des inspecteurs principaux pédagogiques en EPS de la mise en place de l'inspection pédagogique à la fin des années 1970.

Injection of donor-derived splenic dendritic cells plus a nondepleting anti-CD4 monoclonal antibody to prolong primary skin graft survival indefinite…

2010

Abstract We have previously shown that injection of donor-derived Fischer rat OX62+ dendritic cells plus an anti-CD4 monoclonal antibody generates donor-specific CD4+CD25+FoxP3+ regulatory T cells in Lewis rats spleens. The regulatory T cells indefinitely prolonged the survival of skin graft from Fischer rat and abrogated the antidonor antibody response. We have now shown that an injection of 2 × 10 6 donor-derived OX62+ dendritic cells plus 2 mg nondepleting anti-CD4 monoclonal antibody (W3/25) at 28 days before grafting induced indefinite skin graft survival in this combination; whereas an injection on day −1 prolonged it only to 50 days. This effect is donor specific. In both cases, we s…

Cellular and humoral immune responses against cancer: implications for cancer vaccines.

1991

The key issue in tumor immunology is to identify antigens as target structures for a cancer-selective immunological attack in the tumor-bearing host, resulting in tumor rejection. There is a growing detailed understanding of structural and regulatory gene alterations giving rise to candidate rejection antigens and peptides in tumor cells. As well as reviewing the development of new adjuvant and recombinant vector systems, new approaches are suggested for the construction of cancer vaccines.

Microarray analysis of antibodies induced with synthetic antitumor vaccines : specificity against diverse mucin core structures

2017

Glycoprotein research is pivotal for vaccine development and biomarker discovery. Many successful methodologies for reliably increasing the antigenicity toward tumor-associated glycopeptide structures have been reported. Deeper insights into the quality and specificity of the raised polyclonal, humoral reactions are often not addressed, despite the fact that an immunological memory, which produces antibodies with cross-reactivity to epitopes exposed on healthy cells, may cause autoimmune diseases. In the current work, three MUC1 antitumor vaccine candidates conjugated with different immune stimulants are evaluated immunologically. For assessment of the influence of the immune stimulant on a…