Search results for " Genes"
showing 10 items of 322 documents
Identifying modularity structure of a genetic network in gene expression profile data
2009
Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to Imatinib. Imanitib is a drug used to treat certain types of cancer that in many statistical studies has been reported to have a significant clinical effect on chronic myeloid leukemia (CML) in chronic phase as well as in blast crisis. For central module in a GGM we intend a module containing genes that are defined differently expressed.
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
MCRL: using a reference library to compress a metagenome into a non-redundant list of sequences, considering viruses as a case study
2019
Abstract Motivation Metagenomes offer a glimpse into the total genomic diversity contained within a sample. Currently, however, there is no straightforward way to obtain a non-redundant list of all putative homologs of a set of reference sequences present in a metagenome. Results To address this problem, we developed a novel clustering approach called ‘metagenomic clustering by reference library’ (MCRL), where a reference library containing a set of reference genes is clustered with respect to an assembled metagenome. According to our proposed approach, reference genes homologous to similar sets of metagenomic sequences, termed ‘signatures’, are iteratively clustered in a greedy fashion, re…
Identification of stress related genes in mussels from hydrothermal vents and cold seeps
2012
Molecular markers reflect differentiation of Fusarium oxysporum forma speciales on tomato and forma on eggplant
2013
Selective pressure induces pathogens to change their method of infection and, sometimes, causes species to become infectious. Pathogenic fungi must differentiate different morphological and physiological properties during the process of host specialization in their life cycle. In the present study, we conducted a genetic investigation and compared similarities within a generation of Fusarium oxysporum forma speciales (f. sp.) infecting tomato and forma (f.) infecting eggplants using selected ISSR and RAPD markers, two horticultural commodities belonging to the same taxon of the Solanaceae. Interestingly, genetic data showed that fungi belonging to F. oxysporum f. sp. infecting tomato have a…
Impact of assisted reproductive technologies on the regulation of imprinted genes and transposable elements in Human blood cord and placenta
2018
It is estimated that more than five million children have been born by Assisted Reproductive Technologies (ART) worldwide, representing up to 4% of all births. As around 10% of reproductive-aged couples are currently infertile, providing them with treatment options is a public health issue. However, the safety of these techniques has not been fully demonstrated. Notably, the rate of placenta-related adverse pregnancy outcomes could be increased after ART. Moreover, adverse perinatal outcomes, a higher risk of major malformations and imprinting disorders have also been reported in children born following ART. These issues combined raise the question of a potential ART-induced epigenetic vuln…
Polymorphisms of genes of TGF-beta pathway and susceptibility to colorectal cancer
2012
Background: Genetic background implicated in cytokine network may have a key role in the susceptibility to colorectal cancer (CRC). The TGF-β pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Methods: rs1800471 SNP polymorphism of TGF-ß1 rs334348 and rs334349 of TGF-βR1, rs900 of TGF-β2 and rs4522809 of TGF-β2R2 were typed in a group of 82 patients affected by sporadic CRC and in 237 age- and sex-matched healthy controls, using a competitive allele specific PCR assays (KASPar), developed by KBioscience (England). Results: No significant genetic contribution has been observed for 3 of the 5 SNPs tested. Indeed, a sign…
Mechanisms of fluid flow and fluid-rock interaction in fossil metamorphic hydrothermal systems inferred from vein-wallrock patterns, geometry and mic…
2001
Comparison of mass transfer patterns, geometry and microstructures developed within and around veins allows the interpretation of processes of fluid flow during deformation, metamorphism and mineralization. A classification of vein types based on the degree of interaction with wallrock (using petrological, geochemical or isotopic indicators) can be used to identify a range of processes, from closed system behaviour in which the vein mass is derived from local wallrock, through to open system behaviour in which the vein mass is derived externally. Microstructural characteristics, such as wallrock selvages, multiple growth events recorded by vein seams and vein crystal morphology, also help t…
Sperm imprinting integrity in seminoma patients?
2018
IF 4.990; International audience; BackgroundTesticular germ cell tumor such as seminoma is strongly associated with male reproductive problems commonly associated with the alteration of sperm parameters as described in testicular dysgenesis syndrome. Interestingly, numerous studies have reported that the precursor of germ cell cancer, germ cell neoplasia in situ (GCNIS), present similarities to fetal gonocytes, specifically characterized by global DNA hypomethylation particularly on imprinting sequences. These disorders may have a common origin derived from perturbations of embryonal programming during fetal development. Presently, there is no available information concerning the sperm DNA …