Search results for " Genetics"

The Time Course of Emotional Responses to Music

2005

Two empirical studies investigate the time course of emotional responses to music. In the first one, musically trained and untrained listeners were required to listen to 27 musical excerpts and to group those that conveyed a similar emotional meaning. In one condition, the excerpts were 25 seconds long on average. In the other condition, excerpts were as short as 1 second. The groupings were then transformed into a matrix of emotional dissimilarity that was analyzed with multidimensional scaling methods (MDS). We compared the outcome of these analyses for the 25-s and 1-s duration conditions. In the second study, we presented musical excerpts of increasing duration, varying from 250 to 20 s…

D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

2009

The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.

Chloroplast signal length requirement reflects the outer membrane and TOC complex dimension

2015

Background and Purpose: The evolution of an efficient preprotein targeting and translocation system was a central prerequisite for the endosymbiotic integration of a -proteobacteria and cyanobacteria as cellular organelles. Today, it is widely accepted that during evolution most (pre-)proteins destined for these two organelles were equipped with an N-terminal targeting signal for localization. While multiple modes of evolution of these extensions are currently discussed, all evolved signals serve the same function – forming a signal for targeting to the correct organelle and translocation across both membranes. We aimed to generalize the current idea for the length requirement of the N-term…

Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

2016

Fusion energy research has in the past 40 years focused primarily on the tokamak concept, but recent advances in plasma theory and computational power have led to renewed interest in stellarators. The largest and most sophisticated stellarator in the world, Wendelstein 7-X (W7-X), has just started operation, with the aim to show that the earlier weaknesses of this concept have been addressed successfully, and that the intrinsic advantages of the concept persist, also at plasma parameters approaching those of a future fusion power plant. Here we show the first physics results, obtained before plasma operation: that the carefully tailored topology of nested magnetic surfaces needed for good c…

Inhibitory Effects of the Insecticides Allethrin, Lindane, and Jacutin-Fogetten Sublimate on Photosynthetic Electron Transport

1979

Abstract The inhibitory effects of the insecticides Allethrin, Lindane, and Jacutin-Fogetten sublimate on photosynthetic electron transport of broken chloroplasts were tested. 50 μmol l-1 Allethrin caused an inhibition of 80% of the benzoquinone and ferricyanide Hill-reactions. 39 μmol l-1 Lindane inhibited the basal, coupled and uncoupled electron transport to ferricyanide up to 35%. The precipitate formed by the sublimation of Jauctin-Fogetten containing Lindane depressed electron transport much more than pure Lindane. 50 μg ml-1 of the sublimate led to an 80% inhibition of ferricyanide Hill-reaction.

Zur Methodik der Schwefelwasserstoffbestimmung in biologischem Material

1955

�ber Gef�ssabdichtung durch Rutin

1949

Pain killer without a high

2005

THC acts as a pain reliever in part by engaging a receptor in peripheral tissues, CB2. But exactly where CB2 is and how it operates has been unclear. A new study shows that cannabinoids, acting through CB2 on skin cells, stimulate the local release of endogenous opioids.

Distraction of cyclists: how does it influence their risky behaviors and traffic crashes?

2018

BackgroundUndisputedly, traffic crashes constitute a public health concern whose impact and importance have been increasing during the past few decades. Specifically, road safety data have systematically shown how cyclists are highly vulnerable to suffering traffic crashes and severe injuries derived from them. Furthermore, although the empirical evidence is still very limited in this regard, in addition to other human factors involved in cycling crashes, distractions while cycling appear to be a major contributor to the road risk of cyclists.ObjectivesThe main objectives of this study were, first, to explore the prevalence and trends of cycling distractions within an international sample o…

Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group

2016

Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected alo…