Search results for " Home"
showing 10 items of 868 documents
A new actor involved in hypothalamic glucose detection : the Transient Receptor Potential Canonical (TRPC) channels
2015
Hyperglycemia is detected and integrated by the mediobasal hypothalamus (MBH) which, in turn, inhibits food intake and triggers insulin secretion. The MBH houses specialized glucose-sensitive (GS) neurons, which directly or indirectly modulate their electrical activity in response to changes in glucose level. In a first study, we hypothesized that indirect detection of glucose by MBH GS neurons involves the secretion of endozepine by astrocytes, a gliotransmitter known to inhibit food intake in response to hyperglycemia. The present work shows that endozepines selectively activate anorexigenic MBH pro-opiomelanotortine (POMC) neurons. In the second study, we show that the direct detection o…
Long-Term Behavioral Programming Induced by Peripuberty Stress in Rats Is Accompanied by GABAergic-Related Alterations in the Amygdala
2014
Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implicated in anxiety and mood disorders. Abnormal amygdala functioning has also been detected following stress exposure and is also implicated in anxiety and social disorders. However, the amygdala is not a unitary structure; it includes several nuclei with different functions and little is known on the potential differences the impact of early life stress may have on this system within different amygdaloid nuclei. We aimed here to evaluate pote…
IMPROVEMENT IN REDOX HOMEOSTASIS AFTER CYTOREDUCTIVE SURGERY IN COLORECTAL ADENOCARCINOMA
2021
Colorectal cancer (CRC) as one the most common cancer type is associated with oxidative stress. Surgery is the only curative modality for early-stage CRC. The aim of this study was to evaluate the oxidative damage biomarkers as well as enzymatic and nonenzymatic antioxidants in patients with CRC before and after tumor resection and in healthy controls. 60 patients with stage I/II colorectal adenocarcinoma and 43 healthy controls were recruited in this study. We measured plasma levels of oxidative damage biomarkers, including advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), malondialdehyde (MDA), and oxidized low-density lipoprotein (ox-LDL) at baseline and…
A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis
2021
Adult organisms must sense and adapt to environmental fluctuations. In high-turnover tissues such as the intestine, these adaptive responses require rapid changes in gene expression that, in turn, likely involve posttranscriptional gene control. However, intestinal-tissue-specific microRNA (miRNA)-mediated regulatory pathways remain unexplored. Here, we report the role of an intestinal-specific miRNA, miR-958, that non-cell autonomously regulates stem cell numbers during tissue homeostasis and regeneration in the Drosophila adult midgut. We identify its downstream target cabut, the Drosophila ortholog of mammalian KLF10/11 transcription factors, which mediates this miR-958 function by promo…
Design of Photovoltaic System for Rural Electrification in Rwanda
2017
Master's thesis Renewable Energy ENE500 - University of Agder 2017 In this century of accelerated development in various domains, some African countries are still facing a challenge of lack of power due to its scarce in some places, where by the main source of power (generation of electricity) is hydro since thermal and fuel are still on a small scale. This problem results in less productivity and economic decline of some countries like Rwanda which is among African countries that are at a very high speed in development, the grid lines from distant places are stack and they are few compared to the need of electricity in all corners of the country, especially in rural areas whereby each hous…
Predictors of Job Satisfaction among Staff in Residential Settings for Persons with Intellectual Disabilities: A Comparison between Three Residential…
2010
Background This cross-sectional study aims to assess whether there are differences in staff job satisfaction, including organizational and individual characteristics, between three residential models for adults with intellectual disabilities (small residential home, group home and institution) and to investigate the organizational and individual variables associated with staff job satisfaction. Methods A standardized self-administered questionnaire (Job Satisfaction Survey) was distributed together with demographic questions between April 2007 and June 2007. In total, 1301 staff members completed the questionnaire. Results We found that staff working at small homes had a significantly hi…
Parental Monitoring and Youth's Binge Behaviors: The Role of Sensation Seeking and Life Satisfaction
2019
Framed within an ecological perspective of the onset of adolescent problem behaviors, the current study explored the joint role of parent-adolescents’ relationships and youth's individual factors in binge eating and drinking. Firstly, in line with pieces of research highlighting the beneficial impact of effective parenting on youth development, the present paper sought to enhance the knowledge about the positive influence of parental monitoring on youth's binge drinking and eating. Moreover, since literature evidenced that the explanatory mechanisms of the association between parental monitoring and binge behaviors are not fully explored, the study focused on the potential intervening role …
Europeans' willingness to pay for ending homelessness: A contingent valuation study.
2020
The purpose of this study is to assess the utility value European citizens put on an innovative social program aimed at reducing homelessness. The Housing First (HF) model involves access to regular, scattered, independent and integrated housing in the community with the support of a multidisciplinary team. Currently, HF is not implemented by most European countries or funded by healthcare or social plans, but randomised controlled trials have stressed significant results for improved housing stability, recovery and healthcare services use. The broader implementation of HF across Europe would benefit from a better understanding of citizens' preferences and "willingness to pay" (WTP) for med…
Assessing the Costs of Home Palliative Care in Italy: Results for a Demetra Multicentre Study
2022
Background: The sustainability of palliative care services is nowadays crucial inasmuch as resources for palliative care are internationally scarce, the funding environment is competitive, and the potential population is growing. Methods: The DEMETRA study is a multicentre prospective observational study, describing the intensity of care and the related costs of palliative home care pathways. Results: 475 patients were enrolled as recipients of specialized palliative home care. The majority of recipients were cancer patients (89.4%). The mean duration of palliative care pathways was 46.6 days and mean home care intensity coefficient equal to 0.6. The average daily cost of the model with the…
Selected Elements of Lifestyle and the Level of Functional Fitness in Older Women.
2022
Background: The appropriate level of functional fitness is a very important element for seniors to maintain self-reliance in daily life. The aim of this research was to assess sociodemographic differences, selected elements of lifestyle, and functional fitness in the older residents of social welfare homes and community dwellers Methods: The analysed group comprised 693 women aged 65–79, including 173 subjects living in social welfare homes and 520 community-dwelling women. Basic anthropometric features were measured, and functional fitness was assessed using the Senior Fitness Test. Basic sociodemographic characteristics, as well as data on health self-assessment and selected elements of l…