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Umowa o ponoszenie opłat za pobyt w domu pomocy społecznej w orzecznictwie sądów administracyjnych
2016
Implementación de un modelo de atención integral a residencias
2019
Introduction: La incidencia y la prevalencia de patologias cronicas son un reto para los sistemas de salud cuya progresion se preve que aumentara de forma simultanea al envejecimiento poblacional. Short description of practice change implemented: Se presenta un Modelo de Atencion Integral a Residencias en el que, ademas de los niveles asistenciales convencionales (residencias, atencion primaria y hospitalaria) se incorpora el soporte de la Unidad Domiciliaria de Atencion Integral a Residencias (UDAIR), como elemento clave para la continuidad de cuidados y la atencion integrada. Aim and theory of change: Los objetivos principales son mejorar la atencion de las personas que residen en insti…
Relationship between energy metabolism and bone metabolism: a pilot study on gymnasts
Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects w…
2020
Aim: The primary objective of this pilot study was to evaluate the effect of non-surgical periodontal treatment. The secondary aim was to evaluate the effect of dietary therapy on both parameters of oxidative stress in leukocytes and leukocyte-endothelial cell interactions in an obese population. Methods: This was a pilot study with a before-and-after design. Forty-nine obese subjects with periodontitis were randomized by means of the minimization method and assigned to one of two groups, one of which underwent dietary therapy while the other did not. All the subjects underwent non-surgical periodontal treatment. We determined periodontal, inflammatory and oxidative stress parameters&mdash
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.
2015
Objectives:\ud The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.\ud \ud Methods:\ud Pharmacological manipulation of the activity of CRF receptors, CRF1 and CRF2, was performed in 3T3L1 white pre-adipocytes and T37i brown pre-adipocytes during in vitro differentiation. The expression of genes of the CRF/urocortin system and of markers of white and brown adipocytes was evaluated along with mitochondrial biogenesis and cellular oxygen consumption. Metabolic evaluation of corticosterone-deficient or supplemented Crhr1-null (Crhr1−/−) mice and their wild-type controls was performed alo…
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice
2021
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both male and female Negr1−/− mice receiving a standard or high fat diet (HFD). We found that 6 weeks of HFD leads to higher levels of blood glucose in Negr1−/− mice. In the glucose tolerance test, HFD induced phenotype difference only in male mice
Le petit appétit du grand âge
2018
National audience
Vieillissement, adaptation alimentaire au grand âge et petit appétit : le petit mangeur âgé
2018
Atteindre un âge canonique de 100 ans avec toutes les fonctions cognitives et physiques de l'âge adulte est le souhait de chacun. Pour autant, avec le vieillissement, l'héritage génétique, les conditions de vie durant la vie adulte et certains accidents de la vie peuvent faire basculer des personnes âgées plus rapidement que d'autres vers la dépendance, la dénutrition, la fragilité. Simone de Beauvoir écrivait « la sénescence n'est pas une pente que chacun descend à la même vitesse. C'est une volée de marches irrégulières que certains dégringolent plus vite que d'autres ». Le vieillissement a ses surprises et pour un même âge de 90 ans, alors que certains peuvent rivaliser avec les plus jeu…
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2013
Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…
Reliability of Frail and Barthel Tests for Detecting Frailty in Palliative Oncological Patients in a Home Hospitalization Unit: A Comparative Study.
2022
Cancer is a condition that can increase the risk of frailty. In addition, palliative oncological patients in home hospitalization can find their activities of daily living affected. The main objective was to measure the degree of frailty in the oncological population in home hospitalization comparing Barthel and Frail-VIG Indexes. This is a descriptive cross-sectional study. A sample of oncological patients in home hospitalization (n = 50) that included 27 men and 23 women were recruited, and disability due to frailty was measured using the VIG frailty index and the Barthel scale for Activities of Daily Living (ADLs). Spearman’s correlation coefficients were categorized as weak (rs &l…