Search results for " IRON"

Standardized T2* map of normal human heart in vivo to correct T2* segmental artefacts.

2007

A segmental, multislice, multi-echo T2* MRI approach could be useful in heart iron-overloaded patients to account for heterogeneous iron distribution, demonstrated by histological studies. However, segmental T2* assessment in heart can be affected by the presence of geometrical and susceptibility artefacts, which can act on different segments in different ways. The aim of this study was to assess T2* value distribution in the left ventricle and to develop a correction procedure to compensate for artefactual variations in segmental analysis. MRI was performed in four groups of 22 subjects each: healthy subjects (I), controls (II) (thalassemia intermedia patients without iron overload), thala…

Preferential patterns of myocardial iron overload by multislice multiecho T2* CMR in thalassemia major patients.

2010

T*(2) multislice multiecho cardiac MR allows quantification of the segmental distribution of myocardial iron overload. This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty-three thalassemia major patients underwent cardiac MR. Three short-axis views of the left ventricle were acquired and analyzed using a 16-segment standardized model. The T*(2) value on each segment was calculated, as well as the global value. Four main circumferential regions (anterior, septal, inferior, and lateral) were defined. Significant segmental variability was found in the 229 patients with significant myocardial iron overload (glob…

Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses

2013

In women of fertile age, iron loss consequent to excessive menstrual discharge is by far the most frequent cause of iron-deficient anemia. However, the relationship between menstrual discharge and iron loss is poorly understood. In this prospective study, total menstrual and iron losses were assayed in a large cohort of non-anemic women and women with excessive menstrual blood losses (menorrhagia) in order to provide data useful for intervention. One hundred and five Caucasian women aged 20–45 years were recruited. Blood cell count and serum ferritin (SF) levels were determined in each case before menses. Menstrual fluid losses (MFL) were determined using a standardized pads’ weight method.…

Abdominal aortic thrombosis secondary to reactive thrombocytosis in a patient with iron deficiency anemia

2016

Multicenter validation of the magnetic resonance t2* technique for segmental and global quantification of myocardial iron

2009

Purpose To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2* technique for global and segmental measurement of iron overload in thalassemia patients. Materials and Methods Multiecho T2* sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n = 25) within 1 month. T2* images were analyzed using previously validated software. Results T2* values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2* values the correlation coefficient was 0.97, coefficients of variation (CoV…

Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines.

2012

Hookworms produce a vast repertoire of structurally and functionally diverse molecules that mediate their long-term survival and pathogenesis within a human host. Many of these molecules are secreted by the parasite, after which they interact with critical components of host biology, including processes that are key to host survival. The most important of these interactions is the hookworm's interruption of nutrient acquisition by the host through its ingestion and digestion of host blood. This results in iron deficiency and eventually the microcytic hypochromic anemia or iron deficiency anemia that is the clinical hallmark of hookworm infection. Other molecular mechanisms of hookworm infec…

Anemia in non-celiac wheat sensitivity: Prevalence and associated clinical and laboratory features.

2022

Background: Patients suffering from non-celiac wheat sensitivity (NCWS) frequently report extra- intestinal symptoms, such as anemia. Aims: We investigated the prevalence and associated clinical features of anemia in NCWS patients. Methods: Data from 244 NCWS patients, diagnosed by double-blind placebo-controlled wheat challenge, were retrospectively reviewed and compared with 2 control groups (celiac disease (CD) and irritable bowel syndrome (IBS)). Furthermore, 31 NCWS anemic patients were prospectively re-evaluated after at least 12 months on the “strict”wheat-free diet (WFD). Results: Anemia prevalence in NCWS patients was 34.8% (mean hemoglobin 10.4 ±1.4 g/dl), significantly higher tha…

Machine learning for rapid mapping of archaeological structures made of dry stones – Example of burial monuments from the Khirgisuur culture, Mongoli…

2020

11 pages; International audience; The present study proposes a workflow to extract from orthomosaics the enormous amount of dry stones used by past societies to construct funeral complexes in the Mongolian steppes. Several different machine learning algorithms for binary pixel classification (i.e. stone vs non-stone) were evaluated. Input features were extracted from high-resolution orthomosaics and digital elevation models (both derived from aerial imaging). Comparative analysis used two colour spaces (RGB and HSV), texture features (contrast, homogeneity and entropy raster maps), and the topographic position index, combined with nine supervised learning algorithms (nearest centroid, naive…

on the contrasts in the charcoal assemblage of a Late Iron Age and a Romano-British roadside settlement

2019

On the contrasts in the charcoal assemblage of a Late Iron Age and a Romano-British roadside settlement

Marks and Epigraphs on Iberian Amphorae. II

2015

Se presenta la segunda parte del repertorio de marcas y epígrafes sobre ánforas ibéricas, con la intención de completar un fenómeno heredero del mundo púnico. Se pretende ir acotando el/los posible/s significado/s de tales marcas, su distribución territorial y su marco cronológico. Las marcas incisas son, en esta ocasión, más numerosas que las impresas y se ha detectado una nueva técnica postcocción (con pintura y carbón) restringida al noreste peninsular. This paper is the second part of the repertoire of marks and epigraphs on Iberian amphorae. The goal is to complete this work, which is related to the Punic world, and know the possible meanings of such marks, their geographical distribut…