Search results for " Inference"

Comparing various concepts of function prediction. Part 1.

1974

Prediction: f(m+1) is guessed from given f(0), ..., f(m). Program synthesis: a program computing f is guessed from given f(0), ..., f(m). The hypotheses are required to be correct for all sufficiently large m, or with some positive frequency. These approaches yield a hierarchy of function prediction and program synthesis concepts. The comparison problem of the concepts is solved.

On speeding up synthesis and prediction of functions

1974

Inferring slowly changing dynamic gene-regulatory networks

2014

Dynamic gene-regulatory networks are complex since the interaction patterns between its components mean that it is impossible to study parts of the network in separation. This holistic character of gene-regulatory networks poses a real challenge to any type of modelling. Graphical models are a class of models that connect the network with a conditional independence relationships between the random variables. By interpreting the random variables as gene activities and the conditional independence relationships as functional non-relatedness, graphical models have been used to describe gene-regulatory networks. Whereas the literature has been focused on static networks, most time-course experi…

Optimization of Linearized Belief Propagation for Distributed Detection

2020

In this paper, we investigate distributed inference schemes, over binary-valued Markov random fields, which are realized by the belief propagation (BP) algorithm. We first show that a decision variable obtained by the BP algorithm in a network of distributed agents can be approximated by a linear fusion of all the local log-likelihood ratios. The proposed approach clarifies how the BP algorithm works, simplifies the statistical analysis of its behavior, and enables us to develop a performance optimization framework for the BP-based distributed inference systems. Next, we propose a blind learning-adaptation scheme to optimize the system performance when there is no information available a pr…

Recent statistical advances and applications of species distribution modeling

2019

En el mundo en que vivimos, producimos aproximadamente 2.5 quintillones de bytes de datos por día. Esta enorme cantidad de datos proviene de las redes sociales, Internet, satélites, etc. Todos estos datos, que se pueden registrar en el tiempo o en el espacio, son información que puede ayudarnos a comprender la propagación de una enfermedad, el movimiento de especies o el cambio climático. El uso de modelos estadísticos complejos ha aumentado recientemente en el contexto del estudio de la distribución de especies. Esta complejidad ha hecho que los procesos inferenciales y predictivos sean difíciles de realizar. El enfoque bayesiano se ha convertido en una buena opción para lidiar con estos m…

Genomic divergence landscape in recurrently hybridizing Chironomus sister taxa suggests stable steady state between mutual gene flow and isolation

2021

Abstract Divergence is mostly viewed as a progressive process often initiated by selection targeting individual loci, ultimately resulting in ever increasing genomic isolation due to linkage. However, recent studies show that this process may stall at intermediate stable equilibrium states without achieving complete genomic isolation. We tested the extent of genomic isolation between two recurrently hybridizing nonbiting midge sister taxa, Chironomus riparius and Chironomus piger, by analyzing the divergence landscape. Using a principal component‐based method, we estimated that only about 28.44% of the genomes were mutually isolated, whereas the rest was still exchanged. The divergence land…

Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology

2019

Recent advances in cytometry have radically altered the fate of single-cell proteomics by allowing a more accurate understanding of complex biological systems. Mass cytometry (CyTOF) provides simultaneous single-cell measurements that are crucial to understand cellular heterogeneity and identify novel cellular subsets. High-dimensional CyTOF data were traditionally analyzed by gating on bivariate dot plots, which are not only laborious given the quadratic increase of complexity with dimension but are also biased through manual gating. This review aims to discuss the impact of new analysis techniques for in-depths insights into the dynamics of immune regulation obtained from static snapshot …

3 ′-5 ′ crosstalk contributes to transcriptional bursting

2019

Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bay…

Book Review: Statistical Inference as Severe Testing

2019

Estimating the Bayesian posterior distribution of indirect effects in causal longitudinal mediation analysis

Many research studies aim to unveil the causal mechanism underlying a particular phenomenon; mediation analysis is increasingly used for this scope, and longitudinal data are particularly suited for mediation since they ensure the correct temporal order among variables and the time spanning allows the causal effects to unfold. This explains the rise of interest in the topic of longitudinal mediation analysis. Many approaches have been proposed to cope with longitudinal mediation (Fosen et al., 2005; Lin et al., 2017), among which mixed-effect modelling. In a recent paper, Bind et al. (Biostatistics, 2016) made use of generalised mixed effect models and provided conditions for the identifiab…