Search results for " Integra"
showing 10 items of 2527 documents
Power monitoring in dielectric-loaded surface plasmon-polariton waveguides
2011
We report on propagating mode power monitoring in dielectric-loaded surface plasmon-polariton waveguides (DLSPPWs) by measuring the resistance of gold stripes supporting the DLSPPW mode propagation. Inevitable absorption of the DLSPPW mode in metal causes an increase in the stripe temperature and, thereby, in its resistance whose variations are monitored with an external Wheatstone bridge being accurately balanced in the absence of radiation in a waveguide. The investigated waveguide configuration consists of a 1-µm-thick and 10-µm-wide polymer ridges tapered laterally to a 1-µm-wide ridge placed on a 50-nm-thin and 4-µm-wide gold stripe, all supported by a magnesium fluoride substrate. Usi…
Fiber-coupled dielectric-loaded plasmonic waveguides.
2010
Fiber in- and out-coupling of radiation guided by dielectric-loaded surface plasmon-polariton waveguides (DLSPPWs) is realized using intermediate tapered dielectric waveguides. The waveguide structures fabricated by large-scale UV-lithography consist of 1-microm-thick polymer ridges tapered from 10-microm-wide ridges deposited directly on a magnesium fluoride substrate to 1-microm-wide ridges placed on a 50-nm-thick and 100-microm-wide gold stripe. Using fiber-to-fiber transmission measurements at telecom wavelengths, the performance of straight and bent DLSPPWs is characterized demonstrating the overall insertion loss below 24 dB, half of which is attributed to the DLSPPW loss of propagati…
Geostatistical 3-dimensional integration of measurements of soil magnetic susceptibility.
2010
In soil magnetometry, two types of measurements are usually performed. The first type is measurements performed on the soil surface, frequently using an MS2D sensor. The second type includes measurements of magnetic susceptibility carried out in the soil profile, usually to a depth of about 30 cm. Up to now, such measurement results were analyzed separately. However, it is possible and advantageous to integrate these two types of measurements. The goal of the study was to integrate measurements of magnetic susceptibility performed on the soil surface and in the soil profile. More specifically, the goal was to obtain 3-dimensional spatial distributions of magnetic susceptibility of the topso…
Clinical practice guideline for the integrated management of major trauma by the Italian National Institute of Health: process and methods
2021
Background. Major trauma describes serious injuries requiring lifesaving interventions or resulting in long-term disability; it represents about 8% of all deaths worldwide. Specific guidelines can help reduce deaths and disabilities, provided they adhere to high quality and trustworthiness standards. This article aims at introducing the development process of the Istituto Superiore di Sanità, ISS (Italian National Institute of Health) guideline for major trauma integrated management. Methods. We applied the ISS methodological standards including the GRADE-ADOLOPMENT approach for adoption, adaptation, and de novo development of trustworthy guidelines. Results. The scope was formulated by the…
Decision Committee Learning with Dynamic Integration of Classifiers
2000
Decision committee learning has demonstrated spectacular success in reducing classification error from learned classifiers. These techniques develop a classifier in the form of a committee of subsidiary classifiers. The combination of outputs is usually performed by majority vote. Voting, however, has a shortcoming. It is unable to take into account local expertise. When a new instance is difficult to classify, then the average classifier will give a wrong prediction, and the majority vote will more probably result in a wrong prediction. Instead of voting, dynamic integration of classifiers can be used, which is based on the assumption that each committee member is best inside certain subar…
Dynamic Integration of Decision Committees
2000
Decision committee learning has demonstrated outstanding success in reducing classification error with an ensemble of classifiers. In a way a decision committee is a classifier formed upon an ensemble of subsidiary classifiers. Voting, which is commonly used to produce the final decision of committees has, however, a shortcoming. It is unable to take into account local expertise. When a new instance is difficult to classify, then it easily happens that only the minority of the classifiers will succeed, and the majority voting will quite probably result in a wrong classification. We suggest that dynamic integration of classifiers is used instead of majority voting in decision committees. Our…
On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches
2019
The need to facilitate the complex management of cardiometabolic diseases (CMD) has led to the detection of many biomarkers, however, there are no clear explanations of their role in the prevention, diagnosis or prognosis of these diseases. Molecules associated with disease pathways represent valid disease surrogates and well-fitted CMD biomarkers. To address this challenge, data from multi-omics types (genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, and nutrigenomics), from human and animal models, have become available. However, individual omics types only provide data on a small part of molecules involved in the complex CMD mechanisms, whereas, here, we pr…
Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors
2020
Abstract Objectives This study evaluated the emergence of mutations associated with integrase strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in human immunodeficiency virus type 1 (HIV-1) infected patients treated with this drug class. Methods The emergence of INSTI-RMs and integrase evolution (estimated as genetic distance between integrase sequences under INSTI treatment and before INSTI treatment) were evaluated in 107 INSTI-naive patients (19 drug-naive and 88 drug-experienced) with two plasma genotypic resistance tests: one before INSTI treatment and one under INSTI treatment. A logistic regression analysis was performed to evaluate factors associ…
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenot…
2021
The key role of APP for Alzheimer pathogenesis is well established. However, perinatal lethality of germline knockout mice lacking the entire APP family has so far precluded the analysis of its physiological functions for the developing and adult brain. Here, we generated conditional APP/APLP1/APLP2 triple KO (cTKO) mice lacking the APP family in excitatory forebrain neurons from embryonic day 11.5 onwards. NexCre cTKO mice showed altered brain morphology with agenesis of the corpus callosum and disrupted hippocampal lamination. Further, NexCre cTKOs revealed reduced basal synaptic transmission and drastically reduced long-term potentiation that was associated with reduced dendritic length …
Impaired semantic processing during sentence reading in children with dyslexia: combined fMRI and ERP evidence
2008
Developmental dyslexia is a specific disorder of reading acquisition characterized by a phonological core deficit. Sentence reading is also impaired in dyslexic readers, but whether semantic processing deficits contribute is unclear. Combining spatially and temporally sensitive neuroimaging techniques to focus on semantic processing can provide a more comprehensive characterization of sentence reading in dyslexia. We recorded brain activity from 52 children (16 with dyslexia, 31 controls) with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in two separate counterbalanced sessions. The children silently read and occasionally judged simple sentences with seman…