Search results for " Library"
showing 10 items of 734 documents
The Engineering of a Compression Boosting Library: Theory vs Practice in BWT Compression
2006
Data Compression is one of the most challenging arenas both for algorithm design and engineering. This is particularly true for Burrows and Wheeler Compression a technique that is important in itself and for the design of compressed indexes. There has been considerable debate on how to design and engineer compression algorithms based on the BWT paradigm. In particular, Move-to-Front Encoding is generally believed to be an "inefficient " part of the Burrows-Wheeler compression process. However, only recently two theoretically superior alternatives to Move-to-Front have been proposed, namely Compression Boosting and Wavelet Trees. The main contribution of this paper is to provide the first ex…
SeroGRID: an improved method for the rapid selection of antigens with disease related immunogenicity
2003
Screening of cDNA expression libraries derived from human tumors with autologous sera (SEREX) permits the definition of immunogenic antigens in individual cancer patients. However, only a minority of SEREX-derived cDNA clones show a clear cancer-relatedness in the sense that circulating autoantibodies to them occur exclusively in the sera of tumor patients but not in healthy individuals. Evaluation of multiple SEREX-defined clones in serological assays using panels of allogeneic sera from cancer patients as well as appropriate control groups is an important step towards focussing on the relevant antigens. This in turn is the basis for defining disease parameters of diagnostic and prognostic…
On constrained Volterra cubic stochastic operators
2020
We consider constrained Volterra cubic stochastic operators and construct several Lyapunov functions for the constrained Volterra cubic stochastic operators. We prove that such kind operators do no...
Managing patients taking edoxaban in dentistry
2017
Background Anticoagulation therapy is used in several conditions to prevent or treat thromboembolism. A new group of oral anticoagulants with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. The Food and Drug Administration has approved edoxaban, dabigatran, rivaroxaban and apixaban. Their advantages include: predictable pharmacokinetics, drug interactions and limited food, rapid onset of action and short half-life. However, they lack a specific reversal agent. Material and methods This paper examines the available evidence regarding rivaroxaban and sets out proposals for clinical guidance of dental practitioners t…
Impact of functional mandibular advancement appliances on the temporomandibular joint : a systematic review
2015
Background Although many orthodontists have no doubts about the effectiveness of functional appliances for mandibular advancement, the impact on the temporomandibular joint (TMJ) is still in dispute. The objective of this systematic review is to examine the main effects on the TMJ of using functional appliances, both in healthy patients and in patients with a pre-existing disorder. Material and Methods A systematic review of the literature was conducted in accordance with the PRISMA guidelines. Only systematic reviews, meta-analyses, randomized clinical trials (RCTs), case-control studies and cohort studies were included. A detailed language-independent electronic search was conducted in th…
A functional analysis of ACP-20, an adult-specific cuticular protein gene from the beetle Tenebrio. Role of an intronic sequence in transcriptional a…
2004
0962-1075 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't; A gene encoding the adult cuticular protein ACP-20 was isolated in Tenebrio. It consists of three exons interspersed by two introns, intron 1 interrupting the signal peptide. To understand the regulatory mechanisms of ACP-20 expression, ACP-20 promoter-luciferase reporter gene constructs were transfected into cultured pharate adult wing epidermis. Transfection assays needed the presence of 20-hydroxyecdysone, confirming that ACP-20 is up-regulated by ecdysteroids. Analysis of 5' deletion constructs revealed that three regions are necessary for high levels of transcription. Interaction experiments between i…
Clustering-Based Protocol Classification via Dimensionality Reduction
2015
We propose a unique framework that is based upon diffusion processes and other methodologies for finding meaningful geometric descriptions in high-dimensional datasets. We will show that the eigenfunctions of the generated underlying Markov matrices can be used to construct diffusion processes that generate efficient representations of complex geometric structures for high-dimensional data analysis. This is done by non-linear transformations that identify geometric patterns in these huge datasets that find the connections among them while projecting them onto low dimensional spaces. Our methods automatically classify and recognize network protocols. The main core of the proposed methodology…
No association between the cystatin C gene polymorphism and Alzheimer's disease: a case-control study in an Italian population.
2005
Cystatin C is an amyloidogenic protein found together with beta-amyloid in cerebral arteriolar walls of both patients with Alzheimer's Disease (AD) and conghopilic amyloid angiopathy. Several findings implicate cystatin C in the pathogenesis of vascular diseases. Recent genetic association studies proposed cystatin C gene (CST3) as a susceptibility factor for AD, although other reports did not replicate this finding. We conducted a case-control study including 192 probable AD cases and 192 age- and sex-matched controls to test the association between CST3 and AD. Possible interaction between CST3 and age at onset of AD or apolipoprotein E (APOE) was also examined. No significant differences…
Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics
2018
Abstract Background Acute asthma attack is a frequent condition in children. It is one of the most common reasons for emergency department (ED) visit and hospitalization. Appropriate care is fundamental, considering both the high prevalence of asthma in children, and its life-threatening risks. Italian Society of Pediatrics recently issued a guideline on the management of acute asthma attack in children over age 2, in ambulatory and emergency department settings. Methods The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology was adopted. A literature search was performed using the Cochrane Library and Medline/PubMed databases, retrieving studies in Englis…
Nonradioactive Detection of Differentially Expressed Genes Using Complex RNA or DNA Hybridization Probes
1999
The analysis of differential gene expression has become increasingly important in recent years. Typically, differentially expressed genes are identified in a primary screening procedure, yielding candidate genes whose differential expression has to be verified. We provide a highly sensitive, efficient and nonradioactive differential screening procedure to analyze numerous candidate genes in a single step. This comprises labeling of poly(A)+ RNA of the cell types analyzed with DIG Chem-Link and differential hybridization to the candidate genes fixed on dot blots. DIG Chem-Link allows, to our knowledge, for the first time efficient and direct nonradioactive labeling of RNA in vitro. Advantag…