Search results for " Library"
showing 10 items of 734 documents
Genetic determinants of ototoxicity during and after childhood cancer treatment: Protocol for the pancarelife study
2019
BACKGROUND: Survival rates after childhood cancer now reach nearly 80% in developed countries. However, treatments that lead to survival and cure can cause serious adverse effects with lifelong negative impacts on survivor quality of life. Hearing impairment is a common adverse effect in children treated with cisplatin-based chemotherapy or cranial radiotherapy. Ototoxicity can extend from high-tone hearing impairment to involvement of speech frequencies. Hearing impairment can impede speech and language and neurocognitive development. Although treatment-related risk factors for hearing loss following childhood cancer treatment have been identified, the individual variability in toxicity of…
Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia : a systematic rev…
2019
Background Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations that are frequently characterized as architectural and cytological derangements upon histological analysis. Epithelial-mesenchymal transition (EMT) has been proposed as a critical mechanism for the acquisition of the malignant phenotype in neoplastic epithelial processes. This study aims to systematically review the current findings on the immunohistochemical expression of epithelial-mesenchymal transition markers in oral potentially malignant disorders and to evaluate their possible application as biomarkers associated with the progression of oral epithelial dysplasias. Material an…
Prognostic Relevance of Objective Response According to EASL Criteria and mRECIST Criteria in Hepatocellular Carcinoma Patients Treated with Loco-Reg…
2015
Background The European Association for the Study of the Liver (EASL) criteria and the modified Response Evaluation Criteria in Solid Tumors (mRECIST) are currently adopted to evaluate radiological response in patients affected by HCC and treated with loco-regional procedures. Several studies explored the validity of these measurements in predicting survival but definitive data are still lacking. Aim To conduct a systematic review of studies exploring mRECIST and EASL criteria usefulness in predictive radiological response in HCC undergoing loco-regional therapies and their validity in predicting survival. Methods A comprehensive search of the literature was performed in electronic database…
Risk of lymph node metastasis in submucosal esophageal cancer: a review of surgically resected patients
2011
Endoscopic local procedures are increasingly applied in patients with superficial esophageal cancer as an alternative to radical oncologic resection. The objective of this article is to determine the risk of nodal metastases in submucosal (sm) esophageal cancer, comparing the two predominating histologic tumor types, squamous cell cancer (SCC) and adenocarcinoma (ADC).A query of PubMed, MEDLINE, Embase and Cochrane Library (1980-2009) using predetermined search terms revealed 675 abstracts, of which 485 full-text articles were reviewed. A total of 105 articles met the selection criteria. A review of article references and consultation with experts revealed additional articles for inclusion.…
Biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw: A systematic review
2019
Background: The goal of this paper was to identify available biomarkers to predict the onset of biphosphonate-related osteonecrosis of the jaw (BRONJ). Material and Methods: Case-control studies comparing the different concentrations of a series of molecules detected in serum and urine as matrices of BRONJ affected patients vs. non-affected were included. PRISMA guidelines for systematic reviews were used for the present paper. Two reviewers independently screened electronic databases (Medline, Web of science, and The Cochrane Library) and performed hand searches. Risk of bias assessment of selected studies was performed by the Newcastle-Ottawa Scale. This study is registered as PROSPERO CR…
Osteonecrosis of the jaws produced by sunitinib : a systematic review
2019
Background Tyrosine kinase receptor family is involved in tumor growth, pathological angiogenesis and the progression (metastasis) of cancer. Sunitinib (Sutent®) inhibits members of the tyrosine kinase receptor family affecting the induction of angiogenesis and tumor progression. It is not clear if sunitinib increases the risk of osteonecrosis of the jaws (ONJ). The aim of this study was to carry out a systematic review about ONJ related to sunitinib, describing existing cases and possible associated risk factors. Material and Methods The PubMed/MEDLINE and Cochrane Library databases were searched without date restriction up to September 2018. We included prospective and retrospective obser…
Just in case, just in time, or just don't bother? Assessment of one-shot library instruction with follow-up workshops
2015
Published version from the journal: LIBER Quarterly. Available from the publisher at: http://liber.library.uu.nl/index.php/lq/article/view/URN%3ANBN%3ANL%3AUI%3A10-1-116866 This article examines if the timing of library instruction courses is an important part of how students experience library instruction as a means of developing information literacy skills. Two student groups, belonging to different academic subjects, have received the same training and the same assessment questionnaire afterwards. One of the groups was in the middle of writing their student thesis as a part of their final year of their bachelor degree work, the other group consisted of different subjects within the human…
Analysis of B-2-C Social Media Communication in Germany
2018
In this research paper, social media marketing activities of social media accounts from German business are analyzed for the social networks Facebook, Twitter, Instagram, Xing and LinkedIn. As research objects were the context of the interaction, the used and targeted social network functionalities and the behavior of the companies selected. The selection of social media accounts for the research included companies which are currently member from the stock market indices DAX and MDAX, additional online and offline retail business, successful German sports clubs, celebrities and others businesses. Also and to be sure to evaluate high-class social media marketing, the German social media awar…
Timeliness of Open Data in Open Government Data Portals Through Pandemic-related Data: a long data way from the publisher to the user
2020
The paper addresses the “timeliness” of data in open government data (OGD) portals. It is one of the primary principles of open data, which is considered to be a success factor, while at the same time it is one 0f the biggest barriers that can disrupt users trust in data and even the desire to use the entire open data portal. However, assessing this aspect is a very difficult task that, in most cases, becomes an impossible for open data users. There is therefore a lack of comparative studies on the timeliness of data of different national open data portals. Unfortunately, 2020 gave the opportunity to find out this. It became easy enough to compare how long is the data path from the data hol…
Title: The Emergency Medicine Facing the Challenge of Open Science
2020
This article belongs to the Special Issue Data Reuse for Sustainable Development Goals.