Search results for " Library"
showing 10 items of 734 documents
The Efficacy and Safety of Topiramate in the Prevention of Pediatric Migraine: An Update Meta-Analysis
2020
Background: Migraine is the most common acute primary headache in children and adolescents. In 2014, topiramate became the first preventive drug for migraine, approved by the Food and Drug Administration (FDA) for adolescents. This meta-analysis was aimed to evaluate the efficacy and safety of topiramate in the prevention of pediatric migraine.Methods: We searched the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) databases up to June 2019 for eligible randomized controlled trials (RCTs). The primary outcomes were mean migraine days per month, ≥50% reduction rate, and Pediatric Migraine Disability Assessment Scale (PedMIDAS) scores. RevMan5.3 software…
A Lightweight Network Discovery Algorithm for Resource-constrained IoT Devices
2019
Although quite simple, existing protocols for the IoT suffer from the inflexibility of centralized infrastructures and require several configuration stages. The implementation of these protocols is often prohibitive on resource-constrained devices. In this work, we propose a distributed lightweight implementation of network discovery for simple IoT devices. Our approach is based on the exchange of symbolic executable code among nodes. Based on this abstraction, we propose an algorithm that makes even IoT resource-constrained nodes able to construct the network topology graph incrementally and without any a priori information about device positioning and presence. The minimal set of executab…
IPR gender gaps: a first look at utility model, design right and trademark filings
2018
This study extends the analysis of the gender gap in patenting into design rights, utility model (UMs) and trademarks (TMs), which are complementary methods for protecting intellectual property. The analysis is descriptive and uses register data from the Finnish patent and registration office covering the years 1982–2013. A persistent gender gap is found for all intellectual property rights. The gap has narrowed over time for national patent, design right and TM filings but not for UM filings. It is found that, in comparison to men, women are relatively less often single inventors or designers and more often members of inventor or designer teams. peerReviewed
Cloning and expression of a type IX-like collagen in tissues of the ascidian Ciona intestinalis
2002
Collagens are highly preserved proteins in invertebrates and vertebrates. To identify the collagens in urochordates, the total RNA extracted from the pharynx of the ascidian Ciona intestinalis was hybridized with a heterologous probe specific for the echinoderm Paracentrotus lividus fibrillar type I-like larval collagen. Using this probe, two main bands (i.e. 6 and 2.8 kb mRNA) were observed on Northern blot hybridization. The cDNA library prepared from poly(A)+RNA extracted from pharyngeal tissue was screened and a cDNA that specifies a type IX-like collagen was identified. This molecule presents a conceptual open reading frame for a protein containing 734 amino acids. In particular, we sh…
Molecular characterization of an inducible p-coumaric acid decarboxylase from Lactobacillus plantarum: gene cloning, transcriptional analysis, overex…
1997
By using degenerate primers designed from the first 19 N-terminal amino acids of Lactobacillus plantarum p-coumaric acid decarboxylase (PDC), a 56-bp fragment was amplified from L. plantarum in PCRs and used as a probe for screening an L. plantarum genomic bank. Of the 2,880 clones in the genomic bank, one was isolated by colony hybridization and contained a 519-bp open reading frame (pdc gene) followed by a putative terminator structure. The pdc gene is expressed on a monocistronic transcriptional unit, which is transcribed from promoter sequences homologous to Lactococcus promoter sequences. No mRNA from pdc and no PDC activity were detected in uninduced cell extracts, indicating that the…
One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary …
1994
A cDNA library was prepared from peripheral blood lymphocytes of an autoimmune patient with primary Sjögrens' syndrome. The cDNA library was screened with the patients own autoimmune serum being monospecific for the nuclear autoantigen La/SS-B. Thereby an alternative type of La mRNA was identified that differed from the known La mRNA due to an exchange of the exon 1. Sequencing of the genomic region between the exons 1 and 2 showed that the alternative 5'-end is a part of the intron. In addition, the presence of an alternative promoter site, which exists within the intron downstream of the exon 1, became evident. In consequence, the alternative La mRNA is the result of a promoter switching …
Messenger RNA Sequencing of Rare Cell Populations in the Lung and Lung-Draining Lymph Nodes
2017
Next-generation sequencing (NGS) techniques provide unique prospects for in-depth transcriptome analyses. Nevertheless, the emerging and still growing knowledge about the large diversity and heterogeneity of cells that participate in immunological responses in a tissue- and micromilieu-specific manner calls for advanced isolation and sequencing methods for the accurate quantification of gene expression in small cell populations and even individual cells from any organ or tissue. One of the major limitations in performing transcriptome analyses of rare cell populations was and still is quality and quantity of RNA that often limits analyses of complex mixtures of immune cell populations. Here…
El arte de poesía castellana. Desde el pensamiento poético de Encina hacia una colección digital de tratados poéticos
2017
This paper presents the project Poetriae, focusing on the steps already taken and on the ongoing work, as well as on its methods and future steps. Mainly, Poetriae aims at building a digital library of Medieval and Golden Age Castilian poetry treatises. It will create digital editions for them, by philologically marking up each metrical and poetic concept in an unambiguous way, in order to allow treatises to be retrievable not just by bibliographic metadata, but also by key concepts, such as poetic genre, stanza types, rhyme, etc. The project also intends to enable automatic analysis and visualizations of such data. Design and application of specific vocabularies for poetry and metrics are …
Análisis de la implementación Schema.org en el repositorio RODERIC e impacto en el posicionamiento en Google y Google Scholar
2021
espanolSe presenta la implementacion de Schema.org en el repositorio RODERIC de la Universitat de Valencia. Para el analisis del impacto de la implementacion se han definido ocho indicadores que se han analizado en Google Search y Google Scholar segun el caso: visitas, visitas a registros bibliograficos, documentos descargados, impresiones, clics, CTR, posicion media en la SERP y posicion en la SERP que fueron analizados durante dos periodos consecutivos de un ano, antes y despues de la implementacion. Los resultados obtenidos muestran resultados desiguales para ambos buscadores. En el caso de Google Search, a pesar de conseguirse un incremento considerable en el numero de impresiones (21,0…
Evaluar resultados universitarios (II).
1995
La práctica de normalización de la metodología empleada en la evaluación de resultados universitarios en España recurre a autorizadas fuentes de información de los USA. La producción de resultados de la actividad investigadora por parte de Vicerrectorados de investigación y oficinas de transferencia de resultados de investigación ofrece la oportunidad de examinar la correspondencia gastos en I + D, producción de publicaciones científicas, y de plantear la relación universidad-empresa con criterios de reflexividad propios del método documental. La evaluación de la investigación ha cambiado desde que existe el análisis de citas, siendo la experiencia española de la Comisión Nacional de Evalua…