Search results for " Life."
showing 10 items of 18359 documents
Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial
2022
Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…
ESSAI RANDOMISÉ POUR ÉVALUER L’EFFICACITÉ ET LA SÉCURITÉ DE TRAITEMENTS CHEZ DES PATIENTS AMBULATOIRES ATTEINTS DE COVID-19 AYANT DES FACTEURS DE RIS…
2021
Context. The Covid-19 pandemic is of unprecedented magnitude and has had major social and health consequences. Primary care professionals, mainly general practitioners, ensure the care of most patients with Covid-19. An early-stage treatment administered to patients with risk factors for developing a severe disease could reduce hospitalization and death rates. No treatment is currently validated in this indication. Objectives. To evaluate the safety and efficacy of experimental candidate agents delivered in outpatient settings to reduce the risk of hospitalization or death in at-risk patients with early-stage proven Covid-19 and no indication for hospital admission. Methods. Multicentric, o…
Upper thermal threshold of Lepidurus arcticus (Branchiopoda, Notostraca) in lakes on the southern outreach of its distribution range
2021
Qvenild T, Fjeld E, Fjellheim A, Hammar J, Hesthagen T and Lakka H-K. 2021. Upper thermal threshold of Lepidurus arcticus (Branchiopoda, Notostraca) in lakes on the southern outreach of its distribution range. Fauna norvegica 41: 50–88. The Arctic tadpole shrimp Lepidurus arcticus has a circumpolar distribution and the Scandes (Fennoscandian Mountains) marks its southernmost limit in Europe. Within this area, 391 natural and 88 regulated lakes with L. arcticus have been identified, of which 87% are above the treeline. The lakes hosting L. arcticus decrease in altitude from south to north, which results from its temperature preferences. The majority of the locations are at a lower lake air t…
Working hours – tracking the current and future trends
2021
It is important to track the trends of future working hours, since working hours have strong associations to everyday life and work-life interaction, but also to health. In this paper we aim to track the current and future trends in working hours. We discuss the trends through the key dimensions of working hours: the length, timing, tempo and autonomy. We also consider the role of current trends of spatial changes of work. Changes in working time patterns are fostered by several driving factors: globalization and business restructuring challenging the current work organizations, new information technologies, demographic and climate change and the current and future pandemics. The past and c…
Tuottaako pohjoismainen malli hyvää työelämän laatua vielä tulevaisuudessakin?
2017
Pohjoismaat ovat perinteisesti erottuneet työelämän laatuvertailuissa Euroopan ykkösinä. Taustalla vaikuttavat työmarkkinoiden palveluvaltaisuus ja korkea työvoiman osaamistaso, mutta myös erilaiset institutionaaliset tekijät, kuten työmarkkinoiden sääntely, ammattiyhdistysliikkeen asema ja sosiaalipoliittiset ratkaisut. Työelämän laatu voi kuitenkin heikentyä, kun näitä ankkureita kierretään tai kun ne eivät tavoita kaikkien alojen työntekijöitä. Organisaatioiden uudelleenjärjestelyt, ulkoistaminen ja alihankinta sekä uusien alojen ja työnteon uusien muotojen syntyminen saattavat heikentää työelämän laatua. nonPeerReviewed
Evaluation of the animal-assisted therapy in Alzheimer's disease
2017
Animal-assisted therapy sessions have been set up in a protected unit for patients with a dementia-related syndrome. The aim is to measure the effects of animal-assisted therapy on behavioural disorders in daily life and care. The results obtained provided some interesting areas to explore and recommendations with a view to optimising the implementation of such a system.
Identification des agents pathogènes du sol associés aux altérations superficielles du tubercule de pomme de terre
2008
Alternative measures of body composition and wage premium: New evidence from Indonesia
2019
This paper examines the relationship between body composition and earnings in a developing country setting. We use body mass index, waist circumference and hip circumference. Exploiting the panel structure of our longitudinal survey, we find that along with BMI, waist circumference is related to higher earnings in Indonesia. peerReviewed
Income and Career Concerns Among Emerging Adults From Finland, Sweden, and the United Kingdom During COVID-19
2023
In this study, we examine the prevalence of income and career concerns among emerging adults in three different welfare states during COVID-19: Finland ( n = 309), Sweden ( n = 324), and the United Kingdom ( n = 343). This study also delves into how factors such as one’s self-perceived financial situation, generalized mistrust, loneliness and socio-demographics are related to emerging adults’ income and career concerns. Results showed that individuals from the United Kingdom were more likely to experience increased income and career concerns than those in Finland and Sweden. Our results also suggest that income concerns were associated with one’s current financial situation, future financi…
In-depth characterization of denitrifier communities across different soil ecosystems in the tundra
2022
Abstract Background In contrast to earlier assumptions, there is now mounting evidence for the role of tundra soils as important sources of the greenhouse gas nitrous oxide (N2O). However, the microorganisms involved in the cycling of N2O in this system remain largely uncharacterized. Since tundra soils are variable sources and sinks of N2O, we aimed at investigating differences in community structure across different soil ecosystems in the tundra. Results We analysed 1.4 Tb of metagenomic data from soils in northern Finland covering a range of ecosystems from dry upland soils to water-logged fens and obtained 796 manually binned and curated metagenome-assembled genomes (MAGs). We then sear…