Search results for " Local"
showing 10 items of 2101 documents
Unravelling the Mysteries of the [3+2] Cycloaddition Reactions
2018
Resolving Binding Events on the Multifunctional Human Serum Albumin
2020
Abstract Physiological processes rely on initial recognition events between cellular components and other molecules or modalities. Biomolecules can have multiple sites or mode of interaction with other molecular entities, so that a resolution of the individual binding events in terms of spatial localization as well as association and dissociation kinetics is required for a meaningful description. Here we describe a trichromatic fluorescent binding‐ and displacement assay for simultaneous monitoring of three individual binding sites in the important transporter and binding protein human serum albumin. Independent investigations of binding events by X‐ray crystallography and time‐resolved dyn…
Civic resielience : botanical gardens in North America, birth, development, and enviromental awarness
2023
The chapter explores from a historical perspective the birth of botanical gardens in North America, considered a significant part of the ecological network system and of the green and blue 'infrastructure'. This important system opposes geographical risk, which must be organically dealt with in programmes, plans and strategies that protect the landscape, prevent risks, and strengthen short-, medium- and long-term actions, also involving local Communities, integrating the vision to the different scales of intervention and projects. The Botanical Garden, seen here as an 'Open Work', has an important role not only because it preserves botanical specimens that come from all over the world, but …
Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H…
2020
Abstract Objectives Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and survival outcomes for R/M HNSCC in the real-world setting. Materials and methods A multi-site retrospective chart review was conducted in Europe (Germany, United Kingdom, Italy, Spain), Asia Pacific (Australia, South Korea, Taiwan), and Latin/North America (Brazil and Canada) to identify patients who initiated first-line systemic therapy for R/M HNSCC between January 2011 and December 2013. Patients were followed through December 2015 to collect clinical characte…
Les commissions de quartier à l’heure de l’engagement écocitoyen, à Dijon : entre communication stratégique publique locale et construction d’un espa…
2018
This doctoral thesis in Information and Communication Science explores the question of eco-citizen commitment in the neighborhood commissions of Dijon. Many academic or more popular publications in different fields of research (Information and Communication Science, social and environmental psychology, political science, law, philosophy, ecology, etc.) have addressed this issue in recent years. Once the actors of the question had been defined (the inhabitants, elected officials, technicians, representatives of structures and associations, etc.), it was possible to study different instances of participatory democracy in Dijon. The following question ensued : "How are the neighborhood commiss…
Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor
2014
Brain mitochondrial activity is centrally involved in the central control of energy balance. When studying mitochondrial functions in the brain, however, discrepant results might be obtained, depending on the experimental approaches. For instance, immunostaining experiments and biochemical isolation of organelles expose investigators to risks of false positive and/or false negative results. As an example, the functional presence of cannabinoid type 1 (CB1) receptors on brain mitochondrial membranes (mtCB1) was recently reported and rapidly challenged, claiming that the original observation was likely due to artifact results. Here, we addressed this issue by directly comparing the procedures…
Angiogenesis-related prognosis in patients with oral squamous cell carcinoma-role of the VEGF +936 C/T polymorphism.
2014
BACKGROUND: The aim of the study was the immunohistological assessment of VEGF-single nucleotide polymorphism (SNP)-related angiogenic activity in oral squamous cell carcinoma (OSCC) in correlation with prognosis. METHODS: Fifty OSCC samples were immunostained with CD31-antibodies. Mean microvessel density (MVD) and staining intensity were determined and associated with clinicopathological/prognostic features as well as with the VEGF +936C/T SNP. RESULTS: A significant higher MVD could be seen for T3 and T4 compared with T1 and T2, N > 0 vs. N0 as well as G3–G4 vs. G1–G2 OSCCs (all: P < 0.05). A higher MVD was also associated with increased and earlier rates of local relapses, more metastas…
Nucleon localization function in rotating nuclei
2020
Background: An electron localization function was originally introduced to visualize bond structures in molecules. It became a useful tool to describe electron configurations in atoms, molecules and solids. In nuclear physics, a nucleon localization function (NLF) has been used to characterize clusters in light nuclei, fragment formation in fission and pasta phases in the inner crust of neutron stars. Purpose: We use the NLF to study the nuclear response to fast rotation. Methods: We generalize the NLF to the case of nuclear rotation. The extended expressions involve both time-even and time-odd local densities. Since current density and density gradient contribute to the NLF primarily at th…
La calle y el espacio público en la pintura gótica hispana
2001
En los siglos finales de la Edad Media los pintores comenzaron a utilizar su propio entorno como fuente de inspiración para ambientar la historia sagrada. En concreto en la Península Ibérica se han conservado algunas obras en cuyo fondo se reproducen, con mayor o menor fidelidad, calles y plazas de aspecto claramente medieval. El objeto del presente artículo es analizar esas vistas en su doble vertiente: como encuadramiento de las escenas y como elementos de la realidad, observando los modelos que se seguían resaltando la validez de estas fuentes iconográficas para el estudio de la vida cotidiana en el pasado.
Recurrences following treatment of proliferative verrucous leukoplakia: A systematic review and meta-analysis.
2021
Objective A systematic review and meta-analysis was made of the incidence of recurrences in patients with proliferative verrucous leukoplakia subjected to different types of treatment. Methods The study was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. A literature search was made in the Medline (PubMed), EMBASE and Web of Science databases, together with a manual search, covering the period from 1985 to January 2020, with no language restrictions. Studies were included if they described treatments applied to at least 10 patients with the corresponding outcomes. Methodological quality was evaluated using Jadad sca…