Search results for " MIR"
showing 10 items of 304 documents
Plazmas miRNS kā multiplās sklerozes biomarķieri
2018
Vairākos pētījumos ir atklātas miRNS, tajā skaitā cirkulējošas miRNS, kuru daudzums ir izmainīts multiplā sklerozē. miRNS kā jaunu biomarķieru izpēte šai slimībai varētu palīdzēt diagnosticēt un prognozēt tās attīstību agrīnā stadijā. Šajā pētījumā ir prezentēti mūsu dati par dažām miRNS, kas tikadetektētas MS pacientu asins plazmā, kā izmainītas. Mēs salīdzinājām miRNS ekspresijas līmeņus MS un tās apakštipos ar veselo kontroli, lai atrastu potenciālās miRNS, kas var tikt izmantotas, kā MS biomarķieri. Galvenais mērķis bija validēt sekvenēšanas rezultātā atlasītās miRNS, kuru daudzums bija izmainīts MS pacientu asins plazmā neatkarīgā pacientu kopā. miRNS 484, kuras daudzums bija visvairāk…
Genetic and Molecular Characterization of The Human Osteosarcoma 3AB-OS Cancer Stem Cell Line: A Possible Model For Studying Osteosarcoma Origin and …
2013
Finding new treatments targeting cancer stem cells (CSCs) within a tumor seems to be critical to halt cancer and improve patient survival. Osteosarcoma is an aggressive tumor affecting adolescents, for which there is no second-line chemotherapy. Uncovering new molecular mechanisms underlying the development of osteosarcoma and origin of CSCs is crucial to identify new possible therapeutic strategies. Here, we aimed to characterize genetically and molecularly the human osteosarcoma 3AB-OS CSC line, previously selected from MG63 cells and which proved to have both in vitro and in vivo features of CSCs. Classic cytogenetic studies demonstrated that 3AB-OS cells have hypertriploid karyotype wit…
Disabilità visiva e neuroni specchio
2009
Il seguente lavoro ha come obiettivo quello indagare, il possibile coinvolgimento del sistema dei neuroni specchio nella disabilità visiva, cercando di analizzare, in particolare, come il soggetto non vedente possa comprendere e conoscere l’azione degli altri privato dal corpus di informazioni provenienti dal canale visivo. L’ipotesi da verificare è se nei soggetti con disabilità visiva e nei soggetti con sviluppo tipico venga messo in gioco e con quale modalità, lo stesso sistema di neuroni specchio unitario (visivo-uditivo) per il riconoscimento dell’azione. Inoltre, lo studio dovrebbe consentire di verificare se la disabilità visiva ad esordio precoce (congenita) è in grado di aumentare …
Mimonoside D: a new triterpenoid saponin from Mimosa diplotricha Sauvalle (Fabaceae)
2021
A new triterpenoid saponin (Mimonoside D: 3-O-��-L-arabinopyranosyl-3��-hydroxyolean-12-en-28-oic acid 28-O-��-D-xylopyranosyl-(1���2)-��-D- glucopyranoside ester (1)) was isolated from the aerial parts of Mimosa diplotricha Sauvalle together with nine known compounds: 7,4���-dihydroxyflavone (2), kaempferol (3), lupeol (4), betulinic acid (5), ��-sitosterol (6), ��-sitosterol-3-O-��-D-glucopyranoside (7), lutein (8), 5,2���-dihydroxy-7,4���,5���-trimethoxyflavone (9) and vitexin (10). Their structures were elucidated on the basis of spectroscopic (1 D and 2 D nuclear magnetic resonance) and high-resolution mass spectrometric data as well as by comparison of their spectral data with those o…
Orgānu un audu izņemšana no cilvēka - cilvēktiesību pārkāpums?
2017
Darbā “Orgānu un audu izņemšana no cilvēka – cilvēktiesību pārkāpums?” tiek izpētīta likumīga cilvēka orgānu un audu transplantācija, kā arī nelikumīga orgānu un audu izņemšana, kas ir neatļauta un noziedzīga darbība. Orgānu un audu izņemšanas cilvēktiesību jautājums saasinājās pēdējo 40 gadu laikā, sakarā ar zinātnes attīstību transplantācijas jomā un cilvēktiesību lomas pieaugumu medicīnas un pacientu tiesībās. Tāpēc bakalaura darbā autore apskata orgānu un audu izņemšanas juridiskās īpatnības un tas rezultātā radītos cilvēktiesību aizskārumus. Orgānu un audu izņemšanas problēma mūsdienās ir ļoti svarīga un izplatīta, jo orgānu un audu pieprasījums ir lielāks nekā orgānu piedāvājums, tāpē…
L’educazione familiare e il consumo del cinema negli anni Cinquanta tra Nord e Sud d’Italia
2017
In questo articolo, il cinema degli anni Cinquanta viene indagato come mezzo di consumo e come strumento di socializzazione delle masse italiane, in un confronto tra il Nord industrializzato e il Sud ancora prevalentemente agricolo, ma anche tra le zone urbane e quelle rurali, tra classi e tra generi differenti. Seguendo la storia del cinema italiano nel «decennio più lungo del secolo breve», dal neorealismo al melò alla commedia, emerge che il cinema entrava nella vita delle famiglie italiane plasmandole, ridisegnando identità e costruendo nuovi immaginari. Nonostante il diverso approccio con cui le famiglie italiane andavano al cinema, questo fu vissuto come una fonte di istruzione che co…
AMBIENTE COSTRUITO E SOSTENIBILITÀ – Materiali riciclati e Design for Disassembly tra ricerca e buone pratiche
2020
In the context of environmental emergency of which the construction sector is one of the main causes – since it consumes 40% of the (embodied and operational) energy and produces about a third of the total waste – and due to the ambitious objectives set by the international community and by many countries to reduce the environmental impact of buildings during their whole life cycle, this paper wants to make a contribution to the understanding of the state of the art on cycle-based research activities, sustainable experiments and good practices that the building industry and the academy have implemented in recent years. In particular, it refers to cycle-based theoretical and experimental act…
El paisaje en la pintura costumbrista valenciana de finales del siglo XIX: estudio y catalogación de la obra de Luis Beut Lluch (1873-1929)
2016
La presente tesis doctoral, recoge la investigación en el campo de la estética, de uno de los periodos históricos y artísticos más interesantes de la pintura levantina de finales del siglo XIX. Como paso previo a presentar los objetivos, la metodología y el contenido, debemos justificar la presentación de esta investigación en la facultad de filosofía y ciencias de la educación y no en otra facultad más vinculada con las artes y la historia. Teniendo en cuenta que, temporalmente, nuestra investigación se inicia al descubrir la figura de un pintor que, a pesar de la calidad de sus obras y el reconocimiento de sus contemporáneos, no era conocido por el público en las cercanías del 150 anivers…
A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome
2013
Background: Hutchinson-Gilford progeria syndrome is a rare dominant human disease of genetic origin. The average life expectancy is about 20 years, patients’ life quality is still very poor and no efficient therapy has yet been developed. It is caused by mutation of the LMNA gene, which results in accumulation in the nuclear membrane of a particular splicing form of Lamin-A called progerin. The mechanism by which progerin perturbs cellular homeostasis and leads to the symptoms is still under debate. Micro-RNAs are able to negatively regulate transcription by coupling with the 3’ UnTranslated Region of messenger RNAs. Several Micro-RNAs recognize the same 3’ UnTranslated Region and each Micr…
L’ADULTO COME SPECCHIO. MODALITÀ COMUNICATIVE E APPRENDIMENTO
2021
Numerose ricerche sull’infanzia condotte a partire dal secolo scorso, hanno mostrato come i bambini, fin dai primi mesi di vita, siano attivi e propositivi nella interazione con gli altri esseri umani. In una prospettiva educativa, di promozione dei processi di apprendimento e di sostegno alla costruzione di una immagine di sé positiva e fiduciosa nelle proprie potenzialità, sono di grande importanza le modalità comunicative e relazionali degli adulti significativi. A tali modalità farò riferimento nel mio contributo, soffermandomi sul rispecchiamento verbale e non verbale, nelle sue diverse forme, approfondendone le ragioni teoriche e metodologiche e riflettendo su come possa attuarsi una …