Search results for " MODELLI"

Effetto della risoluzione spaziale della mesh sulla modellazione delle frane attivate da precipitazione

2018

Le frane attivate da precipitazione sono, tra tutti gli eventi di dissesto idrogeologico, quelle che probabilmente si verificano con più frequenza. Il verificarsi di tali frane, soprattutto per la velocità con cui inizia e si sviluppa il fenomeno, può comportare conseguenze, a volte anche gravi, per le persone e le cose. In un tale scenario è chiaro che risulta di fondamentale importanza munirsi di strumenti per la previsione del fenomeno nel tentativo di prevenirne e/o mitigarne il rischio che questo comporta. L’utilizzo di modelli idrologici spazialmente distribuiti e a base fisica accoppiati con modelli di stabilità è, oggigiorno, uno tra i metodi più ricorrenti per la valutazione del ri…

Modelización computacional cardiaca

2020

Resumen Las enfermedades cardiovasculares tienen en la actualidad un gran impacto social y economico y constituyen una de las principales causas de mortalidad y morbilidad. Los modelos computacionales personalizados del corazon estan demostrando ser utiles tanto para ayudar a comprender los mecanismos subyacentes a las patologias cardiacas como para optimizar su tratamiento prediciendo la respuesta del paciente. En este contexto, se ha puesto en marcha la Red Espanola de Investigacion en Modelizacion Computacional Cardiaca (V-Heart SN). El objetivo general de V-Heart SN es el desarrollo de un modelo computacional multifisico y multiescala integrado del corazon. Este objetivo general se abor…

Modelización computacional cardiaca

2020

[EN] Cardiovascular diseases currently have a major social and economic impact, constituting one of the leading causes of mortality and morbidity. Personalized computational models of the heart are demonstrating their usefulness both to help understand the mechanisms underlying cardiac disease, and to optimize their treatment and predict the patient's response. Within this framework, the Spanish Research Network for Cardiac Computational Modelling (VHeart-SN) has been launched. The general objective of the VHeart-SN network is the development of an integrated, modular and multiscale multiphysical computational model of the heart. This general objective is addressed through the following spe…

A stochastic model of mutant growth

1987

Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and m…

2019

Abstract Over the latest years phytochemical consumption has been associated to a decreased risk of both the onset and the development of a number of pathological conditions. In this context indicaxanthin, a betalain pigment from Opuntia ficus-indica fruit, has been the object of sound research. Explored, at first, for its mere antioxidant potential, Indicaxanthin is now regarded as a redox-active compound able to exert significant poly-pharmacological effects against several targets in a number of experimental conditions both in vivo and in vitro. This paper aims to provide an overview on the therapeutical effects of indicaxanthin, ranging from the anti-inflammatory to the neuro-modulatory…

A3 adenosine receptor: Homology modeling and 3D-QSAR studies

2012

Adenosine receptors (AR) belong to the superfamily of G-protein-coupled receptors (GPCRs). They are divided into four subtypes (A1, A2A, A2B, and A3) [1], and can be distinguished on the basis of their distinct molecular structures, distinct tissues distribution, and selectivity for adenosine analogs [2,3]. The hA3R, the most recently identified adenosine receptor, is involved in a variety of intracellular signaling pathways and physiological functions [4]. Expression of A3R was reported to be elevated in cancerous tissues [5], and A3 antagonists have been proposed for therapeutic treatments of cancer. The recent literature availability of crystal structure of hA2A adenosine receptor (PDB c…

Modelling the enantioresolution capability of cellulose tris(3,5-dichlorophenylcarbamate) stationary phase in reversed phase conditions for neutral a…

2018

[EN] To the best of our knowledge, the prediction of the enantioresolution ability of polysaccharides-based stationary phases in liquid chromatography for structurally unrelated compounds has not been previously reported. In this study, structural information of neutral and basic compounds is used to model their enantioresolution levels obtained from an immobilised cellulose tris(3,5-dichlorophenylcarbamate) stationary phase in reversed phase conditions. Thirty-four structurally unrelated chiral drugs and pesticides, from seven families, are studied. Categorical enantioresolution levels (RsC, 0 = no baseline enantioresolution and 1 = baseline enantioresolution) are established from the expe…

Statistical Analysis of Biological Models with Uncertainty

2020

In this contribution relevant biological models, based on random differential equations, are studied. For the sake of generality, we assume that the initial condition and the biological model parameters are dependent random variables with arbitrary probability distributions. We present a general methodology that enables us to provide a full probabilistic description of the solution stochastic process for each stochastic model. The statistical analysis is performed through the calculation of the first probability function by applying the random variable transformation technique. From the first probability density function, we can calculate any one-dimensional moment of the solution, includin…

Metadata-Oriented Language Model in Translingual Retrieval of Digital Data

2015

Translingual retrieval relies on processing a source language to retrieve digital document content in a target language. From the perspective of successful browsing digital catalogues, probability of retrieving the full text document in a language other than the query language is close to zero owning to the fact that it is not only the library collection, but especially a problem of matching the index terms with the query keywords which are assumed to be their translation equivalents. In addition, hardly any digital library system is incorporated with a translation component. As a result, such a matching is rather coincidental. Our approach to the translingual document retrieval problem is …

The Multiscale Stochastic Model of Fractional Hereditary Materials (FHM)

2013

Abstract In a recent paper the authors proposed a mechanical model corresponding, exactly, to fractional hereditary materials (FHM). Fractional derivation index 13 E [0,1/2] corresponds to a mechanical model composed by a column of massless newtonian fluid resting on a bed of independent linear springs. Fractional derivation index 13 E [1/2, 1], corresponds, instead, to a mechanical model constituted by massless, shear-type elastic column resting on a bed of linear independent dashpots. The real-order of derivation is related to the exponent of the power-law decay of mechanical characteristics. In this paper the authors aim to introduce a multiscale fractance description of FHM in presence …