Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies

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RESEARCH PRODUCT

Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies

Luisa Tesoriere Alessandro Attanzio Giulia Culletta Marco Tutone Anna Maria Almerico Mario Allegra Maria A. Livrea

subject

Models Molecular Pyridines Opuntia ficus Phytochemicals Context (language use)Antioxidant potential 01 natural sciences Mice Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Multi target Cell Line Tumor Neoplasms Settore BIO/10 - Biochimica Betalain Drug Discovery Animals Humans Cell Proliferation 030304 developmental biology Inflammation Indicaxanthin Multi-target compound Poly-pharmacology Antioxidant Antiinflammatory Antitumoral Antiproliferative Neuromodulator Molecular modelling Pharmacology Biological Products 0303 health sciences Dose-Response Relationship Drug Molecular Structure Traditional medicine 010405 organic chemistry Natural compound Organic Chemistry Opuntia General Medicine Antineoplastic Agents Phytogenic Settore CHIM/08 - Chimica Farmaceutica Betaxanthins 0104 chemical sciences Mice Inbred C57BL Neuroprotective Agents Phytochemical chemistry Blood-Brain Barrier Fruit Drug Screening Assays Antitumor Indicaxanthin

description

Abstract Over the latest years phytochemical consumption has been associated to a decreased risk of both the onset and the development of a number of pathological conditions. In this context indicaxanthin, a betalain pigment from Opuntia ficus-indica fruit, has been the object of sound research. Explored, at first, for its mere antioxidant potential, Indicaxanthin is now regarded as a redox-active compound able to exert significant poly-pharmacological effects against several targets in a number of experimental conditions both in vivo and in vitro. This paper aims to provide an overview on the therapeutical effects of indicaxanthin, ranging from the anti-inflammatory to the neuro-modulatory and anti-tumoral ones and favored by its high bioavailability. Moreover, biochemical and molecular modelling investigations are aimed to identify the pharmacological targets the compound is able to interact with and to address the challenging development in the future research.

year	journal	country	edition	language
2019-10-01	European Journal of Medicinal Chemistry

https://doi.org/10.1016/j.ejmech.2019.07.006