Search results for " Middle"
showing 10 items of 1097 documents
Durability of Dolutegravir-Based Regimens: A 5-Year Prospective Observational Study
2021
This study evaluates the frequency and causes of dolutegravir (DTG) discontinuation along 5 years of follow-up, in both antiretroviral treatment (ART)-naive and experienced people living with HIV (PLWH). This is a prospective multi-center cohort study enrolling PLWH on DTG from July 2014 until November 2020. DTG-durability was investigated using the Kaplan-Meier survival curve. The Cox proportional-hazards model was used for estimating the hazard ratio (HR) of DTG discontinuation for any cause, and for adverse events (AEs). Nine hundred sixty-three PLWH were included, 25.3% were women and 28.0% were ART-naive. Discontinuations for any causes were 10.1 [95% confidence interval (95% CI) 8.9-1…
Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.
2009
Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…
Mapping routine measles vaccination in low- and middle-income countries
2021
The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhoo…
Cernay-lès-Reims (Marne). Cernay-lès-Reims « le Bas de la Noue Saint Rémy » zone 9 [notice archéologique]
2019
Localisée en limite SE de l’agglomération rémoise, sur la commune de Cernay-les-Reims, l’emprise de l’opération porte sur une surface de 11 300 m2. Cette neuvième concentration de vestiges, fouillée sur un parc d’activité, correspond à un établissement rural de l’Antiquité tardive, prolongé à l’époque médiévale par une zone d’activité artisanale. Ces deux occupations se développent le long d’un axe de circulation qui perdure vraisemblablement de l’Antiquité à la première guerre mondiale.
Bar-sur-Aube (Aube). 13 rue Beugnot et 2, 4, 10 rue du Prieuré [notice archéologique]
2019
Un projet immobilier de réhabilitation de l’îlot du prieuré Saint-Pierre (dépendance de l’abbaye Saint-Claude dans le Jura), accolé à l’église éponyme, au NO de la ville ancienne de Bar-sur-Aube, a entraîné la prescription d’un diagnostic archéologique sur les deux « cours » concernées par le projet et sur une analyse du potentiel archéologique conservé en élévation. Ce diagnostic a montré d’importants aménagements médiévaux encore conservés au sein du prieuré Saint-Pierre dont la création est antérieure au milieu du XIIe s., tant dans les élévations que dans les données stratigraphiques. Bien que les remaniements modernes et contemporains soient conséquents, et caractéristiques d’une opéra…
Il dibattito sull’architettura religiosa normanna in Sicilia. Tradizione o innovazione?
2013
Il contributo ripercorre le tappe e presenta le teorie relative al dibattito sui caratteri di innovazione e quelli tradizionali dell'architettura normanna siciliana con riferimento alle strutture latine e quelle greche. The contribution retraces the stages and presents the theories related to the debate on the character of innovation and of tradition Norman architecture in Sicily with reference to the structures Latin and Greek ones.
Accuracy of Transient Elastography in Assessing Fibrosis at Diagnosis in Naïve Patients With Primary Biliary Cholangitis: A Dual Cut-Off Approach
2021
Background & aims Liver fibrosis holds a relevant prognostic meaning in primary biliary cholangitis (PBC). Non-invasive fibrosis evaluation using vibration-controlled transient elastography (VCTE) is routinely performed. However, there is limited evidence on its accuracy at diagnosis in PBC. We aimed to estimate the diagnostic accuracy of VCTE in assessing advanced fibrosis at disease presentation in PBC. Approach & results We collected data from 167 consecutive treatment-naive PBC patients who underwent liver biopsy(LB) at diagnosis at six Italian centers. VCTE examinations were completed within 12 weeks of LB. Biopsies were scored by two blinded expert pathologists, according to Ludwig sy…
A long-snouted late Eifelian arthrodire from Aragon (Spain)
2021
Carolowilhelmina geognostica Carls, 1995 is a large arthrodire (Placodermi) from the Tortodus kockelianus Conodont Zone, late Eifelian, in the Eastern Iberian Cordillera in southern Aragon. The somewhat incomplete but articulated skull is preserved, showing a long tubular rostral plate, very small postnasal plates, low toothless inferognathals, and a small, slender and flat parasphenoid. Supraorbital and central sensory lines meet their antimeres at the midline of the skull, forming a straight double line. Lines along the ventral surface of the rostral plate probably belong to the suborbital branches of the infraorbital sensory lines. The combination of characters of Carolowilhelmina points…
Body mass index categories and anxiety symptoms among adults aged =?50 years from low and middle income countries.
2021
Background: Body weight may be a risk factor for anxiety; however, there is a scarcity of studies on this association in older adults especially from low and middle income countries (LMICs). Therefore, we investigated the association between body mass index (BMI) and anxiety symptoms among adults aged ≥ 50 years from 6 LMICs. Methods: Cross-sectional, community-based, nationally representative data from the World Health Organization (WHO) Study on global AGEing and adult health (SAGE) were analyzed. The BMI was based on measured weight and height and was categorized as: < 18.5 kg/m2 (underweight), 18.5–24.9 kg/m2 (normal weight), 25.0–29.9 kg/m2 (overweight), 30.0–34.9 kg/m2 (obesity cla…
Current trends on subtotal petrosectomy with cochlear implantation in recalcitrant chronic middle ear disorders
2023
Objective. To establish the safety and effectiveness of subtotal petrosectomy with cochlear implantation in patients affected by chronic middle ear disorders to refractory to previous surgical treatments. Methods. A multicentre, retrospective study was conducted on patients affected by recalcitrant chronic middle ear disorders who underwent cochlear implantation in combi-nation with subtotal petrosectomy. Patients’ details were collected from databases of 11 Italian tertiary referral centres. Additionally, a review of the most updated literature was carried out. Results. 55 patients were included with a mean follow-up time of 44 months. Cholestea-toma was the most common middle ear recurren…