Search results for " Mild cognitive impairment"

showing 10 items of 29 documents

Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGA…

2007

Objectives To investigate whether amnestic mild cognitive impairment (aMCI) is characterised by restriction in instrumental activities of daily living (IADL). Further, to examine the role of comorbidity and cognitive performance on IADL changes in aMCI subjects. Methods The study included 132 subjects with aMCI and 249 subjects with no cognitive impairment (NCI), consecutively enrolled as outpatients in a multicentric Italian clinical-based study, the ReGAl Project. All subjects underwent a comprehensive evaluation including clinical examination, laboratory screening, neuroimaging and cognitive and behavioral assessments. Functional status was evaluated by the Lawton's Instrumental Activiti…

GerontologyMalemedicine.medical_specialtyActivities of daily livingSettore MED/25 - PSCHIATRIAComorbidityNeuropsychological Testsbehavioral disciplines and activitiesDisability EvaluationMental ProcessesRating scaleExecutive functionmental disordersmedicine80 and overHumansEffects of sleep deprivation on cognitive performanceCognitive performanceAgedGeriatricsCognitive evaluation theoryAged 80 and overDepressive DisorderCognitive disorderActivities of daily livingMild cognitive impairmentCognitionmedicine.diseaseComorbidityActivities of daily living; Cognitive performance; Comorbidity; Executive function; Mild cognitive impairment; Activities of Daily Living; Aged; Aged 80 and over; Amnesia; Comorbidity; Depressive Disorder; Disability Evaluation; Female; Humans; Male; Mental Processes; Neuropsychological Tests; Geriatrics and Gerontology; Psychiatry and Mental HealthPsychiatry and Mental HealthSettore MED/26 - NeurologiaFemaleactivities of the day livingAmnesiaGeriatrics and GerontologyPsychologyhuman activities
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Anxiety symptoms and mild cognitive impairment among community-dwelling older adults from low- and middle-income countries.

2021

Abstract Aim Anxiety may be a risk factor for mild cognitive impairment (MCI) but there is a scarcity of data on this association especially from low- and middle-income countries (LMICs). Thus, we investigated the association between anxiety and MCI among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa), and the mediational effect of sleep problems in this association. Methods Cross-sectional, community-based, nationally representative data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria. Multivariable logistic regression analy…

GerontologyMalemedicine.medical_specialtyChina*Low- and middle-income countriesIndia*EpidemiologyAnxietyLower riskLogistic regressionGhanaOddsRussia03 medical and health sciencesSouth Africa0302 clinical medicineSmith L. Jacob L. López-Sánchez G. F. Butler L. Barnett Y. Veronese N. Soysal P. Yang L. Grabovac I. Tully M. A. et al. -Anxiety symptoms and mild cognitive impairment among community-dwelling older adults from low- and middle-income countries.- Journal of affective disorders cilt.291 ss.57-64 2021*Anxiety*Sleep problemsEpidemiologymental disordersPrevalenceMedicineDementia*Mild cognitive impairmentHumansCognitive DysfunctionRisk factorAssociation (psychology)Developing CountriesMexicoAgedbusiness.industryMiddle Agedmedicine.disease030227 psychiatryAnxiety Mild cognitive impairment Low- and middle-income countries Sleep problems EpidemiologyPsychiatry and Mental healthClinical PsychologyCross-Sectional StudiesAnxietyFemaleIndependent Livingmedicine.symptombusiness030217 neurology & neurosurgeryJournal of affective disorders
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STUDIO DI SEGMENTAZIONE MORFOVOLUMETRICA IN PAZIENTI CON DECLINO COGNITIVO LIEVE, MALATTIA DI ALZHEIMER E MALATTIA DI PARKINSON

Magnetic Resonance Imaging (MRI) voxel-based morphometry (VBM) Alzheimer Disease (AD) Parkinson Disease (PD) Mild Cognitive Impairment (MCI)Settore MED/37 - Neuroradiologiarisonanza magnetica (MRI) segmentazione morfovolumetrica (VBM) malattia di Alzheimer (AD) malattia di Parkinson PD) declino cognitivo lieve (MCI)Settore MED/36 - Diagnostica Per Immagini E Radioterapia
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Electrocortical networks in Parkinson's disease patients with Mild Cognitive Impairment. The PaCoS study

2019

Abstract Introduction Parkinson's Disease (PD) is frequently associated with cognitive dysfunction ranging from Mild Cognitive Impairment (PD-MCI) to dementia. Few electrophysiological studies are available evaluating potential pathogenetic mechanisms linked to cognitive impairment in PD since its initial phases. The objective of the study is to analyze electrocortical networks related with cognitive decline in PD-MCI for identifying possible early electrophysiological markers of cognitive impairment in PD. Methods From the PaCoS (Parkinson's disease Cognitive impairment Study) cohort, a sample of 102 subjects including 46 PD-MCI and 56 PD with normal cognition (PD-NC) was selected based on…

Male0301 basic medicinemedicine.medical_specialtyParkinson's diseaseQuantitative EEGElectroencephalographyAudiology03 medical and health sciences0302 clinical medicinemental disordersmedicineHumansDementiaCognitive DysfunctionNeuropsychological assessmentCognitive declineTomographyAgedElectrocortical networkElectrocortical networksmedicine.diagnostic_testbusiness.industryParietal lobeMild cognitive impairmentElectroencephalographyParkinson DiseaseCognitionMiddle Agedmedicine.disease030104 developmental biologyNeurologyFrontal lobeDisease ProgressionFemaleNeurology (clinical)Nerve NetElectrocortical networks; Mild cognitive impairment; Parkinson's disease; Quantitative EEG; Neurology; Geriatrics and Gerontology; Neurology (clinical)Geriatrics and GerontologyOccipital lobebusiness030217 neurology & neurosurgeryParkinsonism & Related Disorders
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Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries

2021

Background-\ud \ud The limited available literature suggests that sleep problems are linked to an increased risk of mild cognitive impairment (MCI). However, this association has been little studied to date in low-income settings.\ud \ud Objective-\ud \ud To investigate the association between sleep problems and MCI in a large sample of adults from six low-and middle-income countries (LMICs).\ud \ud Design-\ud \ud Cross-sectional.\ud \ud Setting-\ud \ud Study on Global Ageing and Adult Health (SAGE).\ud \ud Subjects-\ud \ud 32,715 individuals aged ≥50 years with preservation in functional abilities [age range 50–114 years; 51.7% females].\ud \ud Methods-\ud \ud MCI was defined using the Nat…

MaleAging*Low- and middle-income countries[SDV]Life Sciences [q-bio]Middle-aged adultsPsychological interventionSleep problemsLogistic regressionBiochemistry0302 clinical medicineEndocrinology*Sleep problemsPrevalence*Mild cognitive impairmentMedicine030212 general & internal medicineCognitive impairmentMorning*Older adultsAged 80 and overLow- and middle-income countriesMiddle AgedSleep in non-human animals3. Good healthOlder adultsFemaleSleep Wake Disorders*DementiaOdds03 medical and health sciencesmental disordersGeneticsHumansDementiaCognitive DysfunctionDeveloping CountriesMolecular BiologyAged*Middle-aged adultsbusiness.industryMild cognitive impairmentCell Biologymedicine.diseaseCross-Sectional StudiesAgeingSmith L. Shin J. I. Jacob L. Carmichael C. López Sánchez G. F. Oh H. Butler L. T. Barnett Y. Pizzol D. Tully M. A. et al. -Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries.- Experimental gerontology ss.111513 2021DementiaMild cognitive impairment Dementia Sleep problems Low- and middle-income countries Middle-aged adults Older adultsbusiness030217 neurology & neurosurgeryDemographyExperimental Gerontology
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Vascular Risk Factors in Mild Cognitive Impairment Subtypes. Findings from the ReGAl Project.

2007

Abstract Background and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MR…

MaleBrainNeuropsychological TestsMagnetic Resonance ImagingRisk AssessmentSeverity of Illness IndexIschemic Attack TransientRisk FactorsSurveys and QuestionnairesCognitive impairment Mild cognitive impairment subtypes Vascular risk factors White-matter lesionsActivities of Daily LivingPrevalenceHumansFemaleSettore MED/26 - NeurologiaAtrophyCognition DisordersAged
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The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population.

2011

Objective: To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: i) MCI severity, ii) time of assessment, iii) interaction with other factors. Methods: 764 cognitively healthy elderly living in the community, from the Kungsholmen Project. Participants were assessed by direct interview to detect low mood. Subjects were then followed for six years to identify those who developed MCI. People with incident MCI were followed for a further three years to assess progression to dementia. Results: People with low mood at baseline had a 2.7-fold (95% Confidence Interval [CI] 1.9-3.7) increased risk of developing …

MaleDatabases FactualApolipoprotein E4behavioral disciplines and activitiesProdromeCohort Studiesmild cognitive impairmentmental disordersmedicinedepression; epidemiology; mild cognitive impairment; dementiaDementiaHumansCognitive declineAgedSex CharacteristicsMood DisordersCognitive disorderProdromal StageCognitionmedicine.diseaseDiagnostic and Statistical Manual of Mental DisordersPsychiatry and Mental healthMoodData Interpretation StatisticaldepressionDisease ProgressionEducational StatusRegression AnalysisSurgeryepidemiologySettore MED/26 - NeurologiaDementiaFemaleNeurology (clinical)AmnesiaPsychologyCognition DisordersCohort studyClinical psychologyFollow-Up StudiesJournal of neurology, neurosurgery, and psychiatry
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The role of mind theory in patients affected by neurodegenerative disorders and impact on caregiver burden

2020

Abstract Background Theory of Mind (ToM) is defined as the ability to understand mental and emotional state. This ability is assessed also in neurodegenerative disease. Few studies have investigated the impact that social cognition of patients could have on caregiver burden. The aim of this study was to investigate a possible correlation in level of social cognition impairment between patients with different neurodegenerative disorders and their caregivers with possible impact on caregivers burden. Methods we enrolled 48 patients with dementia divided in different groups: Fronto-Temporal Dementia (FTD), Alzheimer Disease (AD), and Mild Cognitive Impairment (MCI) and also the three groups of…

MaleEmotionsTheory of MindDiseaseFronto-temporal dementia03 medical and health sciences0302 clinical medicineSocial cognitionAlzheimer DiseasePhysiology (medical)Theory of mindmental disordersActivities of Daily Livingmedicine80 and overDementiaHumansIn patientCognitive DysfunctionAlzheimer disease; Caregiver; Dementia; Fronto-temporal dementia; Mild cognitive impairment; Theory of mind; Activities of Daily Living; Aged; Aged 80 and over; Alzheimer Disease; Caregivers; Cognitive Dysfunction; Emotions; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurodegenerative Diseases; Theory of MindAgedAged 80 and overbusiness.industryMild cognitive impairmentNeurodegenerative DiseasesGeneral MedicineCaregiver burdenMiddle Agedmedicine.diseaseCaregiverDistressNeurologyCaregivers030220 oncology & carcinogenesisFrontotemporal DementiaSurgeryDementiaFemaleNeurology (clinical)Alzheimer's diseasebusiness030217 neurology & neurosurgeryClinical psychology
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The association between objective vision impairment and mild cognitive impairment among older adults in low- and middle-income countries

2021

Aim: The association between visual impairment and mild cognitive impairment (MCI) has not been investigated to date. Thus, we assessed this association among older adults from six low- and middle-income countries (LMICs) (China, India, Ghana, Mexico, Russia, and South Africa) using nationally representative datasets. Methods: Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Visual acuity was measured using the tumbling ElogMAR chart, and vision impairment (at distance and near) was defined as visual acuity worse than 6/18 (0.48 logMAR) in the better-seeing eye. The definition of MCI was based on the National Institute on Aging…

MaleGerontologyChinaAgingmedicine.medical_specialtyVisual acuitygenetic structuresEpidemiology[SDV]Life Sciences [q-bio]Visual impairmentVision impairmentLogistic regressionOdds03 medical and health sciences0302 clinical medicineEpidemiologyPrevalenceHumansMedicineDementiaCognitive Dysfunction030212 general & internal medicineAssociation (psychology)Developing CountriesAgedLow- and middle-income countriesbusiness.industryMild cognitive impairmentmedicine.diseaseeye diseasesSmith L. Shin J. I. Jacob L. López-Sánchez G. F. Oh H. Barnett Y. Pardhan S. Butler L. Soysal P. Veronese N. et al. -The association between objective vision impairment and mild cognitive impairment among older adults in low- and middle-income countries.- Aging clinical and experimental research 2021Vision impairment Mild cognitive impairment Older adults Low- and middle-income countries EpidemiologyCross-Sectional StudiesAgeingOlder adultsFemaleGeriatrics and Gerontologymedicine.symptombusiness030217 neurology & neurosurgeryAging Clinical and Experimental Research
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Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment

2015

Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmediated damage. Objective: We assessed activity and expression of ACO2 extracted from blood lymphocytes of subjects with AD, mild cognitive impairment (MCI), older adults with normal cognition (OCN, age >= 65 years), and younger adults with normal cognition (YCN, age < 65 years). Plasma levels and activities of antioxidants were also measured. Methods: Blood samples were collected from 28 subjects with AD, 22 with MCI, 21 OCN, and 19 YCN. ACO2 act…

MalePathologyantioxidantAntioxidantmedicine.medical_treatmentLymphocyteMitochondrionmedicine.disease_causePolymerase Chain ReactionPathogenesisVitamin Eoxidative stressLymphocytesaconitase (aconitate hydratase)Aconitate Hydratasereactive oxygen speciesGeneral NeuroscienceACO2General MedicineAlzheimer's diseasemitochondriaPsychiatry and Mental healthClinical Psychologyantioxidantsmedicine.anatomical_structureDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer diseaseAlzheimer's diseaseAzheimer diseasereactive nitrogen speciemedicine.medical_specialtyaconitase (aconitate hydratase); Alzheimer disease; antioxidants; free radicals; lymphocyte; mild cognitive impairment; mitochondria; oxidative stress; reactive nitrogen species; reactive oxygen speciesBlotting Westernfree radicalslymphocytemild cognitive impairmentInternal medicinemedicineHumansCognitive DysfunctionRNA MessengerAgedfree radicaloxidative strebusiness.industryVitamin EAconitasimedicine.diseasereactive nitrogen speciesEndocrinologyGeriatrics and GerontologyAlzheimer's disease; Aconitasi; oxidative stress; Aconitase (aconitate hydratase) Azheimer disease antioxidants free radicals lymphocyte mild cognitive impairment mitochondria oxidative stress reactive nitrogen species reactive oxygen speciesMental Status SchedulebusinessBiomarkersOxidative stressJournal of Alzheimer's Disease
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