Search results for " Myocardial Infarction"

showing 10 items of 247 documents

Fibrinogen as predictor of mortality in a 42-months follow-up after acute myocardial infarction

2002

Fibrinogen mortality acute myocardial infarction
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Circulating miRNA Fingerprint and Endothelial Function in Myocardial Infarction: Comparison at Acute Event and One-Year Follow-Up.

2022

MicroRNAs (miRNA) are major regulators of intercellular communication and key players in the pathophysiology of cardiovascular disease. This study aimed to determine the miRNA fingerprint in a cohort of 53 patients with acute myocardial infarction (AMI) with non-ST-segment elevation (NSTEMI) relative to miRNA expression in healthy controls (n = 51). miRNA expression was initially profiled by miRNA array in the serum of patients undergoing cardiac catheterization during NSTEMI (n = 8) and 1 year past the event (follow-up, n = 8) and validated in the entire cohort. In total, 58 miRNAs were differentially expressed during AMI (p < 0.05), while 36 were modified at follow-up (Fisher’s exact t…

Fisiologia cel·lularMicroRNAsMyocardial InfarctionmicroRNA profile; serum biomarker; myocardial infarction; endothelial cell; let-7e; angiogenesisCytokinesEndothelial CellsHumansGeneral MedicineCirculating MicroRNAMalalties coronàriesNon-ST Elevated Myocardial InfarctionFollow-Up StudiesCells
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Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants: A multicenter case-control study in Italy

2018

Background Cardiovascular diseases are the leading causes of mortality and morbidity in Western countries. The possible synergistic effect of poor adherence to a Mediterranean diet (MD) and other risk factors for acute myocardial infarction (AMI) such as hypertension, cholesterol, ever smoker, BMI> 25, diabetes, has not been deeply studied. Design Case-control study. Methods Patients with first AMI and controls from four tertiary referral Italian centers were screened for enrolment. Dietary information was collected through a questionnaire and a MD adherence score was calculated. Physical activity and smoking habits were also registered. The Synergy Index was calculated according to Rothman…

Genetics and Molecular Biology (all)MaleMultivariate analysisMediterranean dietTertiary Care CenterMyocardial Infarctionlcsh:MedicineBlood PressureMediterranean030204 cardiovascular system & hematologyPathology and Laboratory MedicineDiet MediterraneanVascular MedicineBiochemistryGeographical locationsTertiary Care CentersHabitschemistry.chemical_compoundEndocrinology0302 clinical medicineRisk FactorsSurveys and QuestionnairesMedicine and Health SciencesSmoking HabitsSurveys and Questionnaire030212 general & internal medicineMyocardial infarctionlcsh:ScienceMultidisciplinarySmokingMiddle AgedEuropeHyperlipidemiaItalyResearch DesignSettore MED/42HypertensionFemaleCase-Control StudieHumanResearch Articlemedicine.medical_specialtyAged; Case-Control Studies; Feeding Behavior; Female; Humans; Hypertension; Italy; Male; Middle Aged; Myocardial Infarction; Risk Factors; Smoking; Surveys and Questionnaires; Tertiary Care Centers; Diet Mediterranean; Patient ComplianceReferralEndocrine DisordersSmoking habitHypercholesterolemiaCardiologyResearch and Analysis Methods03 medical and health sciencesSigns and SymptomsDiagnostic MedicineDiabetes mellitusInternal medicineDiabetes MellitusAged; Case-Control Studies; Feeding Behavior; Female; Humans; Hypertension; Italy; Male; Middle Aged; Myocardial Infarction; Risk Factors; Smoking; Surveys and Questionnaires; Tertiary Care Centers; Diet Mediterranean; Patient Compliance; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)medicineHumansEuropean UnionNutritionAgedBehaviorCholesterolbusiness.industryRisk Factorlcsh:RCase-control studyBiology and Life SciencesFeeding Behaviormedicine.diseaseDietAgricultural and Biological Sciences (all)chemistryMetabolic DisordersCase-Control StudiesPatient Compliancelcsh:QPeople and placesbusinessPLOS ONE
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The Interplay between Child Maltreatment and Stressful Life Events during Adulthood and Cardiovascular Problems—A Representative Study

2021

Psychological stress is a major risk factor for cardiovascular diseases. While the relevance of early life stress, such as that which is due to child maltreatment (CM), is well known to impact individual stress responses in the long-term, and data on the interplay between CM and stressful events in adulthood on cardiovascular health are sparse. Here, we aimed to assess how stressful life events in adulthood are associated with cardiovascular health infarction in later life and whether this association is independent of CM. In a cross-sectional design, a probability sample of the German population above the age of 14 was drawn using different sampling steps. The final sample included 2510 pe…

Gerontologyobesityhypertensionstressful life eventsInfarctionStressArticleOddsDiabetes mellitusDiabetes mellitusmedicineHypertonieddc:610ObesityRisk factorChild maltreatmentchild maltreatment; stressful life events; cardiovascular problems; obesity; diabetes; hypertension; myocardial infarctionStress (Psychology)diabetesbusiness.industryStressorRGeneral MedicineOdds ratiomedicine.diseaseObesityMyocardial infarctionmyocardial infarctionCardiovascular diseasesHerzinfarktFettsuchtcardiovascular problemsHypertensionKindesmisshandlungMedicinebusinessPsychosocialDDC 610 / Medicine & healthHerzkrankheitchild maltreatmentStress PsychologicalChild abuseJournal of Clinical Medicine
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Early cardiac unloading with ImpellaCP™ in acute myocardial infarction with ventricular septal defect

2020

Abstract Despite a relative contraindication, mechanical support with Impella™ left ventricular assist device has already been described for ischaemic ventricular septal defect treatment, either as a bridge to surgery, as intraoperative mechanical haemodynamic support, or to ensure intraprocedural haemodynamic stability during device closure. We describe two cases of ventricular septal defect complicating acute myocardial infarction, where the percutaneous ImpellaCP was implanted early (differently than previously described) with the aim of preventing haemodynamic instability, while deferring surgical repair. We present a report of haemodynamic, echocardiographic, biochemical, and clinical …

Heart Septal Defects Ventricularmedicine.medical_specialtyPercutaneousAcute myocardial infarction mechanical complicationmedicine.medical_treatmentMyocardial InfarctionCase ReportLeft ventricular assist device610 Medicine & health030204 cardiovascular system & hematologyVentricular septal defectImpella11171 Cardiocentro Ticino2705 Cardiology and Cardiovascular Medicine03 medical and health sciences0302 clinical medicineInternal medicineDiseases of the circulatory (Cardiovascular) systemMedicineHumans030212 general & internal medicineMyocardial infarctioncardiovascular diseasesContraindicationImpellaSurgical repairbusiness.industryHemodynamicsAcute heart failureHeartPerioperativemedicine.diseaseRC666-701Heart failureVentricular assist deviceCardiologyHeart-Assist DevicesCardiology and Cardiovascular Medicinebusiness
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Epidemiological approach of type 2 myocardial infarction : Etiologies, characteristics, treatment and prognosis.

2020

Introduction: Type 2 Myocardial infarction (MI)has been recently defined as an imbalance between oxygen supply and demand, in the absence of atherothromthrombosis. This work aimed to describe the main etiolgies as well as epidemiological, clinical and prognostic characteristics.Method: Data from patients with type 2 MI were collected from the RICO cohort (Observatoire des Infarctus de Cote d'Or). In a complementary work, we analyzed the retrospective data of the emergency department of Dijon University Hospital.Results: Among 4,436 consecutive patients hospitalized for MI in Dijon emergency department over 3 years, 947 (21%) had type 2 MI (median age: 81 years). In the RICO cohort, 4,572 co…

Infactus du myocardeÉpidémiologieMyocardial infarctionEtiologies[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyÉtiologiesEpidemiologyTyoe 2 myocardial infarctionInfarctus de type 2PronosticPrognosis[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Early and midterm outcomes of bioresorbable vascular scaffolds for ostial coronary lesions: insights from the GHOST-EU registry.

2016

Aims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset, with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term, but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA), left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death, target vessel m…

LCX (29Target lesionMale52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostialp= 0.035)medicine.medical_treatmentMyocardial Infarction304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14Coronary Artery Disease030204 cardiovascular system & hematologyCoronary artery diseasebut their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA)0302 clinical medicineAbsorbable Implants030212 general & internal medicineMyocardial infarctionCircumflexRegistriesTissue Scaffolds32%)Drug-Eluting StentsMiddle AgedThrombosisCoronary VesselsAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA) left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death target vessel myocardial infarction or target lesion revascularisation. The database included a total of 1549 lesions in 1304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14; 16%) LCX (29; 32%) or LAD (47; 52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostial p= 0.618) post-dilation in 43% (versus 58% in the non-ostial group p= 0.008). At quantitative coronary angiography treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37] p= 0.035) but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groups respectively log-rank p= 0.005). The device-oriented composite endpoint occurred respectively in 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025 HR 2.65 [1.41-4.97]).OstiumAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subsetTreatment Outcomein 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025CardiologyFemale549 lesions in 1medicine.symptomCardiology and Cardiovascular MedicineAdultpost-dilation in 43% (versus 58% in the non-ostial groupmedicine.medical_specialtyor LAD (47HR 2.65 [1.41-4.97])but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groupsrespectivelyLesion03 medical and health sciencesPercutaneous Coronary Interventionwith higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long termleft anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular deathInternal medicinemedicineHumanstarget vessel myocardial infarction or target lesion revascularisation. The database included a total of 1Agedp= 0.008). At quantitative coronary angiographybusiness.industryPercutaneous coronary interventionp= 0.618)treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37]log-rank p= 0.005). The device-oriented composite endpoint occurredmedicine.diseaseSurgery16%)businessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

2012

BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Se…

LOCIMyocardial Infarction030204 cardiovascular system & hematologychemistry.chemical_compound0302 clinical medicineHigh-density lipoproteinGene Frequencyplasma HDL cholesterol ; mendelian randomisation ; MIHDL cholesterolsingle nucleotide polymorphismRisk FactorsGENETIC-VARIANTSARTERY-DISEASEProspective StudiesMyocardial infarction0303 health sciencesHDL cholesterol; myocardial infarction; single nucleotide polymorphismISCHEMIC CARDIOVASCULAR-DISEASEGeneral Medicine3. Good healthCardiologylipids (amino acids peptides and proteins)medicine.medical_specialtyDalcetrapibSingle-nucleotide polymorphismPolymorphism Single Nucleotide03 medical and health sciencesInternal medicinemedicineHumansCORONARY-HEART-DISEASEGenetic Predisposition to DiseaseMETAANALYSIS030304 developmental biologyBLOOD CHOLESTEROLbusiness.industryCholesterolCholesterol HDLCase-control studyCholesterol LDLLipaseOdds ratioMendelian Randomization Analysismedicine.diseaseENDOTHELIAL LIPASEATHEROSCLEROSISchemistryCase-Control StudiesbusinessHIGH-DENSITY-LIPOPROTEINBiomarkersEvacetrapibThe Lancet
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Left bundle branch block and myocardial infarction, a diagnosis not always easy: Our experience and review of literature

2012

The occurrence of left bundle branch block (LBBB) is quite common in clinical practice. The changes in cardiac repolarization, caused by this disorder of electric conduction, may mask the presence of an acute myocardial infarction (AMI), delaying the diagnostic-therapeutic iter, with an important impact on prognosis. We describe the case of a woman of 59 years with LBBB, came to our observation for a constrictive chest pain associated with dyspnea. The diagnostic workup for suspected acute coronary syndrome (ACS), initially conducted only on the analysis of the electrocardiogram (negative TnI at entry), showed the presence of coronary arteries free of stenosis. However, the diagnostic confi…

Left Bundle Branch Block (LBBB)medicine.medical_specialtyAcute coronary syndromebusiness.industryLeft bundle branch blockMyocardial InfarctionElectrocardiography in myocardial infarctionmedicine.diseaseChest painElectrocardiogramCoronary arteriesStenosismedicine.anatomical_structureInternal medicinemedicineCardiologyIn patientcardiovascular diseasesMyocardial infarctionmedicine.symptombusinessWorld Journal of Cardiovascular Diseases
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ST segment elevations: Always a marker of acute myocardial infarction?

2013

AbstractChest pain is one of the chief presenting complaints among patients attending Emergency department. The diagnosis of acute myocardial infarction may be a challenge. Various tools such as anamnesis, blood sample (with evaluation of markers of myocardial necrosis), ultrasound techniques and coronary computed tomography could be useful. However, the interpretation of electrocardiograms of these patients may be a real concern. The earliest manifestations of myocardial ischemia typically interest T waves and ST segment. Despite the high sensitivity, ST segment deviation has however poor specificity since it may be observed in many other cardiac and non-cardiac conditions. Therefore, when…

Lung Diseasesmedicine.medical_specialtyBenign early repolarizationRD1-811Gastrointestinal DiseasesChest pain Differential diagnosis ECG Myocardial infarction ST segmentReview ArticleChest painDiagnosis DifferentialChest painElectrocardiographyCardiac Conduction System DiseaseHeart Conduction SystemInternal medicineT wavemedicineHumansST segmentDiseases of the circulatory (Cardiovascular) systemMyocardial infarctionBrugada SyndromeAnamnesisbusiness.industryECGElectrocardiography in myocardial infarctionArrhythmias CardiacEmergency departmentmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareMyocardial infarctionCardiovascular DiseasesST segmentRC666-701CardiologyDifferential diagnosisSurgerymedicine.symptombusinessCardiology and Cardiovascular MedicineIndian Heart Journal
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