Search results for " NANOMEDICINE"
showing 10 items of 34 documents
Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles
2014
Núria Mas,1–3 Irene Galiana,3 Silvia Hurtado,† Laura Mondragón,1–3 Andrea Bernardos,1–3 Félix Sancenón,1–3 María D Marcos,1–3 Pedro Amorós,4 Nuria Abril-Utrillas,5 Ramón Martínez-Máñez,1–3 José Ramón Murguía1,3 1Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain; 2Departamento de Química, Universidad Politécnica de Valencia, Valenci…
Alpha emitting nuclides in nuclear medicine theranostics.
2021
Theranostic applications with radio-isotopes currently are rapidly progressing and expand nuclear medicine application in clinical routine. Alpha emitting isotopes, in particular, have long been hypothesized to achieve relevant advances for the treatment of malignancies. Here, an overview of their properties and the knowledge of radiobiology is reviewed in view of clinical translation. Clinical evidence of radiopharmaceuticals based on alpha emitters is summarized with a focus on recent developments for treatment of metastasized castration resistant prostate cancer.Theranostische Anwendungen mit Radioisotopen machen derzeit rasche Fortschritte und erweitern den Einsatz der Nuklearmedizin in…
Naphthalimide imidazolium-based supramolecular hydrogels as bioimaging and theranostic soft materials
2020
1,8-Naphthalimide-based imidazolium salts differing for the alkyl chain length and the nature of the anion were synthesized and characterized to obtain fluorescent probes for bioimaging applications. First, their self-assembly behavior and gelling ability were investigated in water and water/dimethyl sulfoxide binary mixtures. Only salts having longer alkyl chains were able to give supramolecular hydrogels, whose properties were investigated by using a combined approach of fluorescence, resonance light scattering, and rheology measurements. Morphological information was obtained by scanning electron microscopy. In addition, conductive properties of organic salts in solution and gel state we…
Manganese iron oxide superparamagnetic powder by mechanochemical processing. Nanoparticles functionalization and dispersion in a nanofluid
2012
Manganese ferrite nanoparticles were synthesized using a High-Energy Ball-Milling mechanochemical method. After 1 h of milling, the process produces a material consisting of single crystalline domain nanoparticles having a diameter of about 8 nm. Chemical properties of the synthesized powders allow an easy functionalization with citric acid. Both as-obtained and functionalized samples show superparamagnetic behaviour at room temperature, and the functionalized powder is stably dispersible in aqueous media at physiological pH. The average hydrodynamic diameter is equal to similar to 60 nm. Nanoparticles obtained by the reported High-Energy Ball-Milling method can be synthesized with high yie…
Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia.
2017
Daniel Gündel,1 Mareli Allmeroth,2 Sarah Reime,1 Rudolf Zentel,2 Oliver Thews1 1Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle (Saale), 2Institute of Organic Chemistry, Johannes Gutenberg-University, Mainz, Germany Background: Polymeric nanoparticles allow to selectively transport chemotherapeutic drugs to the tumor tissue. These nanocarriers have to be taken up into the cells to release the drug. In addition, tumors often show pathological metabolic characteristics (hypoxia and acidosis) which might affect the polymer endocytosis.Materials and methods: Six different N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer structures (homopolymer as well as…
Stacking as a key property for creating nanoparticles with tunable shape: The case of squalenoyl-doxorubicin
2019
The development of elongated nanoparticles for drug delivery is of growing interest in recent years, due to longer blood circulation and improved efficacy compared to spherical counterparts. Squalenoyl-doxorubicin (SQ-Dox) conjugate was previously shown to form elongated nanoparticles with improved therapeutic efficacy and decreased toxicity compared to free doxorubicin. By using experimental and computational techniques, we demonstrate here that the specific physical properties of SQ-Dox, which include stacking and electrostatic interactions of doxorubicin as well as hydrophobic interactions of squalene, are involved in the formation of nanoassemblies with diverse elongated structures. We …
Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
2015
Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis Núñez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl), Trieste, Italy; 4Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of C…
Study of Uptake Mechanisms of Halloysite Nanotubes in Different Cell Lines
2021
Giuseppa Biddeci,1,2 Gaetano Spinelli,1 Marina Massaro,2 Serena Riela,2 Paola Bonaccorsi,3 Anna Barattucci,3 Francesco Di Blasi1 1Institute for Innovation and Biomedical Research (IRIB), CNR, Palermo, 90146, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Sect. Chemistry, University of Palermo, Palermo, 90128, Italy; 3Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 98158, ItalyCorrespondence: Francesco Di BlasiInstitute for Innovation and Biomedical Research (IRIB), CNR, Via Ugo La Malfa 153, Palermo, 90146, ItalyTel +39 0916809514Email francesco.diblasi@irib.cnr.itPurpose: Hal…
Radiation-engineered polymer nano-platforms for targeted drug delivery
2016
In the last twenty years, several nanobiomaterial-based nanocarriers, so-called nanoplatforms, have been proposed for the treatment of life- threating or quality-of-life-impairing diseases. The role of the nanocarrier is to increase drug localisation via passive and active targeting, to protect the drug from degradation and premature clearance, to facilitate its bypass through biological barriers and increase uptake by cells. For a successful translational research, the system composition should be as simple as possible, and the manufacturing processes should be fast, flexible and should enable a rapid product development from lab-scale to low cost, large-scale production. With this focus, …
Radiation-induced synthesis of nanogels: advances in research and applications
2016
From their first appearance in 1969, when Schnagel and Borwardt reported the radiochemical synthesis of poly(ethylene oxide) microgels by gamma-irradiation, the possibility of generating crosslinked micro- and nanoparticles from ”pure” aqueous solutions of macromolecules, have triggered the imagination of material scientists on the search for ”clean” processes and products for biomedical applications. Thanks to the seminal studies of Rosiak and co-workers, who have clarified, both experimentally and mechanistically, the key role of intra-molecular crosslinking in controlling the particle size, the scientific community has now a powerful tool to design and manufacture radiation-synthetized n…