Search results for " OD"
showing 10 items of 1206 documents
Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold
2020
Background In periodontal patients with jawbone resorption, the autologous bone graft is considered a "gold standard" procedure for the placing of dental prosthesis; however, this procedure is a costly intervention and poses the risk of clinical complications. Thanks to the use of adult mesenchymal stem cells, smart biomaterials, and active biomolecules, regenerative medicine and bone tissue engineering represent a valid alternative to the traditional procedures. Aims In the past, mesenchymal stem cells isolated from periodontally compromised gingiva were considered a biological waste and discarded during surgical procedures. This study aims to test the osteoconductive activity of FISIOGRAF…
Sustained oscillations in the MAP kinase cascade.
2016
Abstract The MAP kinase cascade is a network of enzymatic reactions arranged in layers. In each layer occurs a multiple futile cycle of phosphorylations. The fully phosphorylated substrate then serves as an enzyme for the layer below. This paper focuses on the existence of parameters for which Hopf bifurcations occur and generate periodic orbits. Furthermore it is explained how geometric singular perturbation theory allows to generalize results from simple models to more complex ones.
Octopamine Shifts the Behavioral Response From Indecision to Approach or Aversion in Drosophila melanogaster
2018
Animals must make constant decisions whether to respond to external sensory stimuli or not to respond. The activation of positive and/or negative reinforcers might bias the behavioral response towards approach or aversion. To analyze whether the activation of the octopaminergic neurotransmitter system can shift the decision between two identical odor sources, we active in Drosophila melanogaster different sets of octopaminergic neurons using optogenetics and analyze the choice of the flies using a binary odor trap assay. We show that the release of octopamine from a set of neurons and not acetylcholine acts as positive reinforcer for one food odor source resulting in attraction. The activat…
Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery
2019
The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application a…
Lamotrigine use in pregnancy and risk of orofacial cleft and other congenital anomalies
2016
Objective: To test previous signals of a risk of orofacial cleft (OC) and clubfoot with exposure to the antiepileptic lamotrigine, and to investigate risk of other congenital anomalies (CA).Methods: This was a population-based case–malformed control study based on 21 EUROCAT CA registries covering 10.1 million births (1995–2011), including births to 2005 in which the clubfoot signal was generated and a subsequent independent study population of 6.3 million births. A total of 226,806 babies with CA included livebirths, stillbirths, and terminations of pregnancy following prenatal diagnosis. First-trimester lamotrigine monotherapy exposure in OC cases and clubfoot cases was compared to other …
Space-filling vs. Luzin's condition (N)
2013
Let us assume that we are given two metric spaces, where the Hausdorff dimension of the first space is strictly smaller than the one of the second space. Suppose further that the first space has sigma-finite measure with respect to the Hausdorff measure of the corresponding dimension. We show for quite general metric spaces that for any measurable surjection from the first onto the second space, there is a set of measure zero that is mapped to a set of positive measure (both measures are the Hausdorff measures corresponding to the Hausdorff dimension of the first space). We also study more general situations where the measures on the two metric spaces are not necessarily the same and not ne…
$\Omega$-symmetric measures and related singular integrals
2019
Let $\mathbb{S} \subset \mathbb{C}$ be the circle in the plane, and let $\Omega: \mathbb{S} \to \mathbb{S}$ be an odd bi-Lipschitz map with constant $1+\delta_\Omega$, where $\delta_\Omega>0$ is small. Assume also that $\Omega$ is twice continuously differentiable. Motivated by a question raised by Mattila and Preiss in [MP95], we prove the following: if a Radon measure $\mu$ has positive lower density and finte upper density almost everywhere, and the limit $$ \lim_{\epsilon \downarrow 0} \int_{\mathbb{C} \setminus B(x,\epsilon)} \frac{\Omega\left((x-y)/|x-y|\right)}{|x-y|} \, d\mu(y) $$ exists $\mu$-almost everywhere, then $\mu$ is $1$-rectifiable. To achieve this, we prove first that if …
Integrability of orthogonal projections, and applications to Furstenberg sets
2022
Let $\mathcal{G}(d,n)$ be the Grassmannian manifold of $n$-dimensional subspaces of $\mathbb{R}^{d}$, and let $\pi_{V} \colon \mathbb{R}^{d} \to V$ be the orthogonal projection. We prove that if $\mu$ is a compactly supported Radon measure on $\mathbb{R}^{d}$ satisfying the $s$-dimensional Frostman condition $\mu(B(x,r)) \leq Cr^{s}$ for all $x \in \mathbb{R}^{d}$ and $r > 0$, then $$\int_{\mathcal{G}(d,n)} \|\pi_{V}\mu\|_{L^{p}(V)}^{p} \, d\gamma_{d,n}(V) \tfrac{1}{2}$ and $t \geq 1 + \epsilon$ for a small absolute constant $\epsilon > 0$. We also prove a higher dimensional analogue of this estimate for codimension-1 Furstenberg sets in $\mathbb{R}^{d}$. As another corollary of our method,…
Visible parts of fractal percolation
2009
We study dimensional properties of visible parts of fractal percolation in the plane. Provided that the dimension of the fractal percolation is at least 1, we show that, conditioned on non-extinction, almost surely all visible parts from lines are 1-dimensional. Furthermore, almost all of them have positive and finite Hausdorff measure. We also verify analogous results for visible parts from points. These results are motivated by an open problem on the dimensions of visible parts.
Medium-Term Culture of Primary Oral Squamous Cell Carcinoma in a Three-Dimensional Model: Effects on Cell Survival Following Topical 5-Fluororacile D…
2012
Since the activity of several conventional anticancer drugs is restricted by resistance mechanisms and dose-limiting side-effects, the design of formulations for local application on malignant lesions seems to be an efficient and promising drug delivery approach. In this study, the effect of locally applied 5-FU on cell death was evaluated both in a SCC4/HEK001 model and in a newly proposed 3D outgrowth model of oral squamous cell carcinoma (OSCC). Initially, the optimal drug dose was established by delivery of solutions containing different amounts of 5-FU. The solution containing 1% (w/v) of 5-FU resulted effective in inducing cell death with complete eradication of cell colonies. Buccal …