Search results for " OUTCOMES"
showing 10 items of 356 documents
Translating results from the cardiovascular outcomes trials with glucagon-like peptide-1 receptor agonists into clinical practice: Recommendations fr…
2022
Glucagon-like peptide-1 (GLP-1) receptor agonists mimic the action of the endogenous GLP-1 incretin hormone, improving glycaemic control in type 2 diabetes mellitus (T2DM) by increasing insulin secretion and decreasing glucagon secretion in a glucose-dependent manner. However, as cardiovascular (CV) morbidity and mortality is common in patients with T2DM, several trials with the use of GLP-1 receptor agonists (RAs) have been performed focusing on endpoints related to cardiovascular disease rather than metabolic control of T2DM. Following the positive cardiovascular effects of liraglutide, dulaglutide and semaglutide observed in these trials, major changes in T2DM management guidelines have …
Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics: Patient character…
2021
Background: Treatment resistant depression (TRD; failure to respond to ≥2 treatments) affects ~20% of patients with major depressive disorder (MDD). Real-world data could help describe patient characteristics and TRD disease burden, to assess the unmet needs of TRD patients in Europe. Methods: This observational study collected data from adults with moderate to severe TRD initiating a new treatment for depression, according to local standards of care. At baseline, socio-demographic characteristics, medical history, prior and current treatments were recorded. Disease severity, health-related quality of life (HRQoL), functionality and productivity were assessed. Results: Overall, 411 eligible…
Impact of reslizumab on outcomes of severe asthmatic patients: current perspectives.
2018
Approximately 5%-10% of asthmatics suffer from severe asthma. New biological treatments represent a great opportunity to reduce asthma burden and to improve asthma patients' lives. Reslizumab will soon be available in several European countries. This anti-IL-5 IgG4/kappa monoclonal antibody, administered intravenously at a dose of 3 mg/kg over 20-50 minutes every 4 weeks, has been shown to be safe and effective in patients with 400 eosinophils/mu L or more in their peripheral blood. The clinical effects in reducing asthma exacerbations and in improving the quality of life and lung function are clear, but further research is needed to determine the best biological compound for a specific clu…
Shadows under the North Star- The inequality developing in Finnish school education
2018
In Finland, the National Core Curriculum for Basic Education is supposed to ensure equal opportunity for enrollment to upper secondary education by defining the learning objectives for each school subject at the end of basic education. The first nine years of education in Finland are described locally as ‘basic education’. Having equal learning opportunity as the leading ideal of educational equity implies that no statistically significant differences should prevail between groups, such as genders or regions. This study sets out to map the fulfilment of equality via two research questions: How do learning outcomes at the end of basic education vary across certain background variables in thr…
The Long term Outcomes of Early Educational Differentiation in France
2016
International audience
International perspectives on radiology practice metrics: Australia, France, Germany, Japan, New Zealand, Spain, the UK and USA.
2014
INTRODUCTION The delivery of health care around the world is remarkably diverse in 2015. A comparison of the approximately 200 national entities on the planet reveals marked differences in national measures, both on the input side, such as health care spending, and in outcomes, such as life span. Using the percentage of gross domestic product as a metric for comparing health care spending, the current variation among nations is almost an order of magnitude, from the Marshall Islands and the United States at close to 20% to Myanmar at about 2% [1]. Outcomes are also highly variable, with an almost 2-fold difference in life span between the best and worst nations [2]. Within the nations repre…
Personal Employability and employment outcomes in a university sample: a study before and after COVID-19
2021
[EN] Labour market uncertainty makes difficult to get (and keep) a high-quality job even for graduate students. Moreover, this situation has been worsened due to the COVID-19 pandemic. The aim of this study is to test the influence that personal employability has on maintaining (or being able to find a new) high-quality job in a sample of young university graduates that faced the job market crisis caused by the COVID-19 pandemic. We focus on the four personal employability dimensions of Fugate et al.’s (2004) model: career identity, personal adaptability, human capital, and social capital. Our hypotheses state that the four dimensions of employability are positively related with employment …
Expanding education through user charges : what can be achieved in Malawi and other LDCs ?
1986
International audience; Two features mark the education sector in many LDCs today: first, education is publicly provided; and second. governments are faced with severe financial constraints. As a result, enrollmrnts are confined to low Ievels, and there is excess demand. To mitigate these adverse outcomes, we consider user charges as a means to mobilize additional resources for education. Under the circumstances that characterize most LDCs. we show that (i) families are willing to pay for education: (ii) the resources collected through user charges could finance a sizable expansion of education; and (iii) scholarships can offset the equity effects of user charges.
Fairness Considerations in Labor Union Wage Setting : A Theoretical Analysis
2012
We consider a theoretical model in which unions not only take the outside option into account, but also base their wage-setting decisions on an internal reference, called the fairness reference. Wage and employment outcomes and the shape of the aggregate wage-setting curve depend on the weight and the size of the fairness reference relative to the outside option. If the fairness reference is relatively high compared to the outside option, higher wages and lower employment than in the standard model will prevail. If hit by an adverse technology shock, the economy will then react with a stronger downward adjustment in employment, whereas real wages are more rigid than in the standard model. W…
Relative age at school entry, school performance and long-term labour market outcomes
2015
This article examines the impact of relative age at school entry on school performance, educational attainment and labour market outcomes later in life. We find that the advantages of maturity at school entry are short-lived with relative age having no impact on the years of formal education, adulthood earnings or employment. Our findings are consistent with the view that assumes modest maturity effects in countries where formal education begins late and there are no ability-differentiated learning groups at initial grades. peerReviewed