Search results for " Opera"

Gli obblighi di comportamento degli operatori finanziari nei contratti di credito ai consumatori relativi a beni immobili residenziali

Improving e-economy by regional governments

2014

Purpose – The purpose of this paper is to analyse and assess a government support programme for business innovation in a very peripherical European region: the Spanish region of Andalucía. Design/methodology/approach – Endogenous development approach is used to categorize the main public and private actions included in the government ICT support programme. Cross-time analysis has been carried out by using three territorial indicators of diffusion and effective use of ICT: the physical aspect, refereed to the infrastructures used as a base for the information society development (infrastructures, technology and equipment); the actors and their degree of organization (firms present on the in…

Delphi method applied to horticultural cooperatives

2012

PurposeAgricultural cooperatives have been able to become a strong and consolidated organizational form, although the new challenges of globalization and trade liberalization require changes in the strategic approach. The requirements of the distribution companies, consumers and government about the concentration of demand, traceability, food safety and respect for the environment had led to a thorough reorganization of agricultural food systems. So it is necessary to undertake a strategic review of horticultural cooperatives in order to conduct a strategic assessment and hence identify the strategic actions to be followed in the coming years. This paper seeks to address these issues.Design…

A method for the territorial organization of socio-sanitary services

1983

The need for a profound change in the health service has recently led to the development of a national sanitary plan, which the Italian government has submitted to the political and social forces as a midterm strategy for the transformation of the health service.

Spectral analysis of the Neumann-Poincaré operator and characterization of the stress concentration in anti-plane elasticity

2012

When holes or hard elastic inclusions are closely located, stress which is the gradient of the solution to the anti-plane elasticity equation can be arbitrarily large as the distance between two inclusions tends to zero. It is important to precisely characterize the blow-up of the gradient of such an equation. In this paper we show that the blow-up of the gradient can be characterized by a singular function defined by the single layer potential of an eigenfunction corresponding to the eigenvalue 1/2 of a Neumann–Poincare type operator defined on the boundaries of the inclusions. By comparing the singular function with the one corresponding to two disks osculating to the inclusions, we quant…

A sub-supersolution approach for Neumann boundary value problems with gradient dependence

2020

Abstract Existence and location of solutions to a Neumann problem driven by an nonhomogeneous differential operator and with gradient dependence are established developing a non-variational approach based on an adequate method of sub-supersolution. The abstract theorem is applied to prove the existence of finitely many positive solutions or even infinitely many positive solutions for a class of Neumann problems.

Everolimus With Reduced Tacrolimus Improves Renal Function in De Novo Liver Transplant Recipients: A Randomized Controlled Trial

2012

    In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) everolimus initiation with reduced-exposure tacrolimus (EVR+Reduced TAC) or (iii) standard-exposure tacrolimus (TAC Control). Randomization to TAC Elimination was terminated prematurely due to a higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced TAC was noninferior to TAC Control for the primary efficacy endpoint (tBPAR, graft loss or death at 12 months posttransplantation): 6.7% versus 9.7% (-3.0%; 95% CI -8.7, 2.6%; p<0.001 for noninferiority [12% margin]). tBPAR occurred in…

Polymorphism in the immunoglobulin-like domains of the receptor tyrosine kinase from the sponge Geodia cydonium.

1996

Sponges [Porifera] are the phylogenetically oldest phylum of the Metazoa. They are provided with both cellular and humoral allorecognition systems. The underlying molecules are not yet known. To study allorecognition in sponges we first determined the frequency of graft rejection in a natural population of the marine sponge Geodia cydonium. We then determined, for the first time at the molecular level, the degree of sequence polymorphism in segments of one molecule which may be related to sponge allorecognition and host defense: the Ig-like domains from the receptor tyrosine kinase [RTK]. Thirty six pairs of auto- and allografts were assayed, either by parabiotic attachment or insertion of …

Increased expression of the potential proapoptotic molecule DD2 and increased synthesis of leukotriene B4 during allograft rejection in a marine spon…

2000

Sponges (Porifera) are a classical model to study the events during tissue transplantation. Applying the 'insertion technique' autografts from the marine sponge Geodia cydonium fuse within 5 days. In contrast, allografts are rejected and destroyed. Here we show that during allograft rejection the cells in the grafts undergo apoptosis; 5 days after transplantation 46% of the cells show signs of apoptosis. In a previous study it was shown that during this process a tumor necrosis factor-like molecule is induced in allo- and xenografts. Molecules grouped to the superfamily of tumor necrosis factor receptors and a series of associated adapter molecules contain the characteristic death domain. T…

First report on fertility after allogeneic uterus transplantation

2010

Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.