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Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Trans…

2020

In this prospective randomized study, we compared the outcomes of single-unit umbilical cord blood transplantation (UCBT) and unmanipulated haploidentical stem cell transplantation (haplo-SCT) with post-transplantation cyclophosphamide (PTCy) in adults with hematologic malignancies. All patients received a myeloablative conditioning (MAC) regimen consisting of thiotepa, busulfan, and fludarabine, with antithymocyte globulin (ATG) added for UCBT recipients. Nineteen patients were randomized to UCBT and the other 26 to haplo-HSCT. Four patients (15%) allocated to the haplo-HSCT arm lacked a suitable donor and were crossed over to the UCBT arm. Finally, 23 underwent UCBT and 22 underwent haplo…

Adultmedicine.medical_specialtyendocrine systemHematologic malignancyTransplantation ConditioningHaploidentical transplantationGraft vs Host DiseaseContext (language use)ThioTEPAGastroenterologyMAC Regimen03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansCumulative incidenceProspective StudiesTransplantationAllogeneic stem cell transplantation clinical trial Alternative donor transplantation Haploidentical transplantation Hematologic malignancy Umbilical cord blood transplantationUmbilical cord blood transplantationbusiness.industryHematopoietic Stem Cell TransplantationHematologyAlternative donor transplantationFludarabineTransplantationRegimenAllogeneic stem cell transplantation clinical trialsurgical procedures operative030220 oncology & carcinogenesisHematologic NeoplasmsCord Blood Stem Cell TransplantationNeoplasm Recurrence LocalbusinessBusulfan030215 immunologymedicine.drug
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Melatonin Content of Human Milk: The Effect of Mode of Delivery

2020

Objective: Cesarean section rates are increasing in developed countries and could be performed as an emergency or elective procedure. Our research aim was to determine whether elective cesarean sec...

Adultmedicine.medical_specialtygenetic structuresSection (typography)BreastfeedingPediatricsMelatoninPregnancyMaternity and MidwiferymedicineHumansLactationLongitudinal StudiesProspective Studieshealth care economics and organizationsreproductive and urinary physiologyMelatoninMilk HumanCesarean SectionObstetricsbusiness.industryVaginal deliveryColostrumHealth PolicyInfant NewbornObstetrics and GynecologyDelivery Obstetricfemale genital diseases and pregnancy complicationsBreast Feedingsurgical procedures operativeMode of deliveryFemalebusinessDeveloped countrymedicine.drugBreastfeeding Medicine
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Laparoscopic En Bloc Right Diaphragmatic Peritonectomy for Diaphragmatic Endometriosis According to the Sugarbaker Technique

2016

Abstract Study Objective To evaluate the feasibility of a novel laparoscopic procedure for complete eradication of diaphragmatic endometriosis (DE). Design A retrospective multicenter study (Canadian Task Force Classification II-2). Setting University tertiary referral centre. Patients A consecutive series of 9 women with DE. Interventions Laparoscopic en bloc eradication using Sugarbaker's peritonectomy technique with or without diaphragmatic resection for DE. All surgical procedures were performed by the same surgeon in 2 tertiary referral centers (Charite University, Berlin, Germany, and Catholic University of the Sacred Heart, Foundation John Paul II, Campobasso, Italy). Measurements an…

Adultmedicine.medical_specialtymedicine.medical_treatmentDiaphragmOperative TimeEndometriosisEndometriosisDiaphragmatic breathingDiaphragmatic endometriosi03 medical and health sciencesPostoperative Complications0302 clinical medicineDiaphragmatic endometriosis; Laparoscopy; Peritonectomy; Sugarbaker's technique; Adult; Diaphragm; Endometriosis; Female; Germany; Humans; Italy; Laparotomy; Muscular Diseases; Operative Time; Postoperative Complications; Retrospective Studies; Laparoscopy; Obstetrics and Gynecology; Medicine (all)Muscular DiseasesPeritonectomyGermanyLaparotomymedicineHumansLaparoscopyDiaphragmatic endometriosisRetrospective StudiesLaparotomy030219 obstetrics & reproductive medicineSugarbaker's techniquemedicine.diagnostic_testbusiness.industryMedicine (all)Obstetrics and GynecologyRetrospective cohort studyPerioperativemedicine.diseaseSymptomatic reliefSurgeryPeritonectomySettore MED/40 - GINECOLOGIA E OSTETRICIAItaly030220 oncology & carcinogenesisFemaleLaparoscopybusinessJournal of Minimally Invasive Gynecology
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Is it really useful the Harmonic scalpel in axillary dissection for locally advanced breast cancer? A case series.

2017

Background. The seroma is one of the most common complications in the axillary lymph nodal dissection (different surgical approaches have been tried to reduce the seroma incidence). In our study we evaluate the outcome of patients using or not the ultrasonic scalpel (Harmonic scalpel) according to a standardized surgical technique. Patients and Methods. From January 2011 to December 2015 120 patients underwent axillary dissection for breast cancer. Patients were divided in two groups: patients belonging to the first group underwent Harmonic scalpel dissection and patients belonging to the second group underwent classical dissection. Each group consisted of 60 patients. Quadrantectomy (QUAD)…

Adultmedicine.medical_specialtymedicine.medical_treatmentHarmonic scalpelBreast NeoplasmsAxillary dissection03 medical and health sciences0302 clinical medicineBreast cancerHematomaBreast CancermedicineHarmonic scalpelHumansAxillary dissection; Breast Cancer; Harmonic scalpel; Volume drainage; SurgeryAgedAged 80 and overbusiness.industryVolume drainageMiddle Agedmedicine.diseaseSurgerybody regionsDissectionsurgical procedures operativeLymphedema030220 oncology & carcinogenesisSeromaLymphatic MetastasisAxillaLymph Node ExcisionSurgery030211 gastroenterology & hepatologyFemaleOriginal ArticlebusinessQuadrantectomyMastectomyIl Giornale di chirurgia
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Does the use of fibrin glue prevent seroma formation after axillary lymphadenectomy for breast cancer? A prospective randomized trial in 159 patients.

2010

Background Seroma formation frequently occurs in patients who have undergone axillary lymphadenectomy. The aim of the study was to evaluate the effect of fibrin glue in the prevention of seroma formation after axillary lymphadenectomy. Materials and Methods Hundred fifty-nine breast cancer patients about to undergo quadrantectomy or mastectomy plus axillary lymphadenectomy were enrolled in the study and randomized into two groups. Fibrin glue spray applied to the axillary fossa plus placement of closed suction drainage were used in 80 patients (group A); placement of closed suction drainage was only used in 79 patients (group B). Results Group A patients showed a slight advantage with regar…

Adultmedicine.medical_specialtymedicine.medical_treatmentseroma formationBreast NeoplasmsFibrin Tissue AdhesiveSuctionlaw.inventionbreast cancerBreast cancerPostoperative ComplicationsRandomized controlled triallawmedicineHumansIn patientProspective StudiesFibrin glueMastectomyAgedAged 80 and overbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseSurgeryfibrin glueSettore MED/18 - Chirurgia Generalesurgical procedures operativeSeromaOncologyAxillary LymphadenectomySeromaAxillaLymph Node ExcisionSurgeryFemaleTissue Adhesivesaxillary lymphadenectomybusinessQuadrantectomyMastectomyJournal of surgical oncology
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Postrenal anuria in pelvic or acetabular injury: a report of three cases.

1996

Renal failure due to obstruction by a retroperitoneal hematoma is a rarely discussed complication in pelvic or acetabular fractures. Three cases of this obstructive uropathy are presented. They were successfully treated with removal of the hematoma and draining of the retroperitoneal space.

Adultmedicine.medical_specialtyurologic and male genital diseasesAnuriaRetroperitoneal hematomaFractures BoneHematomamedicineRetroperitoneal spaceHumanscardiovascular diseasesRetroperitoneal SpacePelvic BonesObstructive uropathyAgedHematomabusiness.industryAccidents TrafficAcetabulumMiddle Agedmedicine.diseaseAcetabulumSurgerybody regionssurgical procedures operativemedicine.anatomical_structurecardiovascular systemAnuriamedicine.symptomComplicationbusinessKidney diseaseThe Journal of trauma
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Novel preoperative predictive score to evaluate lymphovascular space involvement in endometrial cancer: an aid to the sentinel lymph node algorithm.

2020

IntroductionSentinel lymph node (SLN) dissection has been recognized as a valid tool for staging in patients with endometrial cancer. Several factors are predictors of recurrence and survival in endometrial cancer, including positive lymphovascular space invasion. The aim of this study is to formulate a pre-operative score that, in the event of no-SLN identification, may give an estimate of the true probability of lymphovascular space invasion and guide management.MethodologyThis was a multi-institutional retrospective study conducted from January 2007 to December 2017. We included all patients with any grade endometrial tumor with a complete pathological description of the surgical specime…

Adultmedicine.medical_treatmentSentinel lymph node03 medical and health sciences0302 clinical medicineMedicineHumansGrading (tumors)Lymph nodeAgedNeoplasm StagingRetrospective StudiesAged 80 and over030219 obstetrics & reproductive medicineReceiver operating characteristicbusiness.industryEndometrial cancerObstetrics and Gynecologylymph nodeMiddle Agedmedicine.diseaseLymphovascularEndometrial Neoplasmsmedicine.anatomical_structureOncology030220 oncology & carcinogenesisSLN and lympadenectomyendometrial neoplasmLymphadenectomyFemaleLymphSentinel Lymph Nodeuterine neoplasmsbusinessAlgorithmAlgorithmsInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society
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Laparoscopic aortic lymphadenectomy in left-sided inferior vena cava

2020

Transposition of the inferior vena cava (IVC), also known as left-sided IVC (LS-IVC), is a rare congenital variant which results from regression of the right supracardinal vein and persistence of the left supracardinal vein in embryonic development.[1 2][1] LS-IVC occurs in 0.2–0.5% of the general

Adultoperativemedicine.medical_specialtycervical cancermedicine.medical_treatmentVena Cava Inferiorgynecologic surgical proceduresLeft sidedInferior vena cavaGynecologic surgical proceduresLeft supracardinal vein03 medical and health sciences0302 clinical medicinelaparoscopegynecologic surgical proceduresurgical procedures operativeHumansMedicineadenocarcinoma030219 obstetrics & reproductive medicinebusiness.industryObstetrics and Gynecologysurgical proceduresSurgerylaparoscopesSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologymedicine.vein030220 oncology & carcinogenesiscardiovascular systemLymph Node ExcisionLaparoscopyFemaleLymphadenectomybusinessRight supracardinal veinInternational Journal of Gynecologic Cancer
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Robust consensus in social networks and coalitional games

2014

We study an n-player averaging process with dynamics subject to controls and adversarial disturbances. The model arises in two distinct application domains: i) coalitional games with transferable utilities (TU) and ii) opinion propagation. We study conditions under which the average allocations achieve robust consensus to some predefined target set.

Adversarial systemMathematical optimizationProcess (engineering)Game theory networks allocations robust receding horizon control.EconomicsSettore MAT/09 - Ricerca OperativaSet (psychology)Mathematical economicsGame theory
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The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity?

2018

Due to aging of the world population, older patients accessing health services are becoming continuously more frequent. This has increased the interest in assessing frailty and vulnerability in all specialties and general medicine. Although the term frailty has been recognized for over 30 years, there is not yet a universally recognized definition, and different care providers assess frailty and vulnerability with dissimilar tools, from very complex to very simple validated scales. Being treated with respect and dignity at the right time and place is the key message, as well as after undergoing a global evaluation both in urgency/emergency and in programmed surgery for all older surgical pa…

AgingSettore MED/09 - Medicina InternaFrail Elderlymedia_common.quotation_subjectVulnerability030204 cardiovascular system & hematologyRisk Assessment03 medical and health sciencesDignity0302 clinical medicineOlder patientsIntervention (counseling)HumansMedicineAging; Frailty; Morbidity; Surgery; Aged; Aged 80 and over; Frail Elderly; Humans; Surgical Procedures Operative; Frailty; Risk Assessment; Aging; Geriatrics and Gerontology030212 general & internal medicineSimplicityAgedmedia_commonAged 80 and overFrailtybusiness.industryWorld populationmedicine.diseaseSurgical riskSurgical Procedures OperativeSurgeryMedical emergencyMorbidityGeriatrics and GerontologybusinessRisk assessmentHuman
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