Search results for " PRIN"

Automated detection and localization system of myocardial infarction in single-beat ECG using Dual-Q TQWT and wavelet packet tensor decomposition.

2019

Abstract Background and objective It is challenging to conduct real-time identification of myocardial infarction (MI) due to artifact corruption and high dimensionality of multi-lead electrocardiogram (ECG). In the present study, we proposed an automated single-beat MI detection and localization system using dual-Q tunable Q-factor wavelet transformation (Dual-Q TQWT) denoising algorithm. Methods After denoising and segmentation of ECG, a fourth-order wavelet tensor (leads × subbands × samples × beats) was constructed based on the discrete wavelet packet transform (DWPT), to represent the features considering the information of inter-beat, intra-beat, inter-frequency, and inter-lead. To red…

A regular variational boundary model for free vibrations of magneto-electro-elastic structures

2011

In this paper a regular variational boundary element formulation for dynamic analysis of two-dimensional magneto-electro-elastic domains is presented. The method is based on a hybrid variational principle expressed in terms of generalized magneto-electro-elastic variables. The domain variables are approximated by using a superposition of weighted regular fundamental solutions of the static magneto-electro-elastic problem, whereas the boundary variables are expressed in terms of nodal values. The variational principle coupled with the proposed discretization scheme leads to the calculation of frequency-independent and symmetric generalized stiffness and mass matrices. The generalized stiffne…

A meshfree method for transverse vibrations of anisotropic plates

2003

A meshfree approach, called displacement boundary method, for anisotropic Kirchhoff plate dynamic analysis is presented. This method is deduced from a variational principle, which uses a modified hybrid functional involving the generalized displacements and generalized tractions on the boundary and the lateral deflection in the domain as independent variables. The discretization process is based on the employment of the fundamental solutions of the static problem operator for the expression of the variables involved in the functional. The stiffness and mass matrices obtained for the dynamic model are frequency-independent, symmetric and positive definite and their computation involves bound…

BIEM-based variational principles for elastoplasticity with unilateral contact boundary conditions

1998

The structural step problem for elastic-plastic internal-variable materials is addressed in the presence of frictionless unilateral contact conditions. Basing on the BIEM (boundary integral equation method) and making use of deformation-theory plasticity (through the backward-difference method of computational plasticity), two variational principles are shown to characterize the solution to the step problem: one is a stationarity principle having as unknowns all the problem variables, the other is a saddle-point principle having as unknowns the increments of the boundary tractions and displacements, along with the plastic strain increments in the domain. The discretization by boundary and i…

Robust stabilisation of 2D state-delayed stochastic systems with randomly occurring uncertainties and nonlinearities

2013

This paper is concerned with the state feedback control problem for a class of two-dimensional (2D) discrete-time stochastic systems with time-delays, randomly occurring uncertainties and nonlinearities. Both the sector-like nonlinearities and the norm-bounded uncertainties enter into the system in random ways, and such randomly occurring uncertainties and nonlinearities obey certain mutually uncorrelated Bernoulli random binary distribution laws. Sufficient computationally tractable linear matrix inequality–based conditions are established for the 2D nonlinear stochastic time-delay systems to be asymptotically stable in the mean-square sense, and then the explicit expression of the desired…

La cathédrale en chantier. La construction du transept de Saint-Étienne de Sens d'après les comptes de la fabrique. 1490-1517

1999

International audience

Determination of Pareto frontier in multi-objective maintenance optimization

2011

Abstract The objective of a maintenance policy generally is the global maintenance cost minimization that involves not only the direct costs for both the maintenance actions and the spare parts, but also those ones due to the system stop for preventive maintenance and the downtime for failure. For some operating systems, the failure event can be dangerous so that they are asked to operate assuring a very high reliability level between two consecutive fixed stops. The present paper attempts to individuate the set of elements on which performing maintenance actions so that the system can assure the required reliability level until the next fixed stop for maintenance, minimizing both the globa…

Droplet-to-droplet microarray for drug screening in picoliter scale

2012

Advanced Drug Screening platforms by Inkjet printing

2011

In this work, we show a low-cost, speed, microarray-based drug screening platform that employs inkjet printing drug dispensing on an enzymatic-rich surface. Mixtures of a model substrate (Dglucose)/ inhibitor (D-glucal) couple have been inkjet printed on a target enzymatic monolayer (glucose oxidase) linked to a functionalized silicon oxide solid surface [1]. It has been possible to fabricate microarrays with quality factors as high as those of conventional pin printing spotting. By a simple horseradish-based colorimetric enzymatic assay, the detection of biological activity at the single spot has been proved. The figure shows a scheme of the platform: molecular inks of the enzymatic substr…

3D-Printed Solid Dispersion Drug Products.

2019

With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further research and development is required in this area to introduce more 3D printed products into the market. Our study investigates the potential of fixed dose combination solid dispersion drug products generated via 3D printing. Two model drugs&mdash