Search results for " PUM"
showing 10 items of 412 documents
Uso degli inibitori di pompa protonica in un Policlinico Universitario
2012
Summary Introduction Proton pump inhibitors (PPIs) are highly prescribed drugs in Italy and in particular in the Sicilian region but little is known about their use in the hospital setting. Materials and methods PPI utilization and related costs were reviewed retrospectively by examining the pharmaceutical records of drug dispensation to the various wards of the Policlinico Universitario P. Giaccone of Palermo in 2010. Differences in the prescribing rates and drug preferences among the different clinical wards were analyzed. Results A total of 20,420 patients were hospitalized at the Policlinico of Palermo in 2010. Overall, the consumption of PPIs was 120 DDD/100 bed-days for the year 2010 …
Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources.
2006
Aims To compare information on drug–drug interactions (DDIs) reported on two standard drug-related information sources (Summary of Product Characteristics and Drugdex system by Micromedex), by assessing the prevalence and predictors of potential DDI with proton pump inhibitors (PPIs) in general practice. Methods From the ‘Caserta-1’ Local Health-Service database, 156 general practitioners (GPs) were recruited. From more than 180 000 individuals registered on their lists, we selected patients receiving co-prescription of PPI and medications at interaction risk, according to the Italian Summary of Product Characteristics (SPC) of PPI and Drugdex information, during the year 2003. Thereafter, …
Clinical pharmacology and safety profile of esomeprazole, the first enantiomerically pure proton pump inhibitor
2001
Awareness of important differences in the pharmacological profile of individual optical isomers of chiral drugs led to the development of esomeprazole, the S-isomer of omeprazole, a new pharmacological entity designed to improve the clinical outcome of available proton pump inhibitors in the management of acid-related disorders. The superior acid control achieved by esomeprazole is mainly due to an advantageous metabolism compared with racemate omeprazole, leading to improved bioavailability and to enhanced delivery of the drug to the gastric proton pump.
Vibrational relaxation of Na2 molecules in a triplet state: collisional transfer from a mixed A 1Σu+ − b3Πu gateway level to long-lived levels of b 3…
1997
Abstract Collision-induced vibrational transitions of Na2 within the b 3Π1u state have been observed in a free jet expansion, using two CW dye lasers for the pump and probe steps. The b-state is entered by the pump laser using a low mixed ( A 1 Σ u + − b 3 Π u ) level as a gateway. The occupations of various v′,J′-levels are studied as functions of the position in the flowing gas. The radiative lifetimes of Na2 in levels which had been populated by vibrational relaxation are found to be very long (> 4 μs). Cross-sections are estimated for vibrationally inelastic collisions with Na and Ar atoms.
The multixenobiotic resistance mechanism in the marine sponge Suberites domuncula: its potential applicability for the evaluation of environmental po…
1996
Experiments were carried out with the marine sponge Suberites domuncala to determine whether sponges may express - like mammalian tumor cells a multidrug-like transporter system. The results demonstrate that sponge cells possess such a protective system termed multixenobiotic resistance (MXR) pump or P-glycoprotein-like pump, The protein was identified by antisera for the mammalian P170 multidrug resistance protein as a 130 kDa molecule, Binding studies were performed with H-3-vincristine (H-3-VCR) and membrane vesicles ; this process is ATP-dependent and inhibited by verapamil, which is known to reverse the multidrug-resistance phenotype in mammalian systems, Accumulation experiments were …
Gigahertz Single-Electron Pumping Mediated by Parasitic States
2018
In quantum metrology, semiconductor single-electron pumps are used to generate accurate electric currents with the ultimate goal of implementing the emerging quantum standard of the ampere. Pumps based on electrostatically defined tunable quantum dots (QDs) have thus far shown the most promising performance in combining fast and accurate charge transfer. However, at frequencies exceeding approximately 1 GHz, the accuracy typically decreases. Recently, hybrid pumps based on QDs coupled to trap states have led to increased transfer rates due to tighter electrostatic confinement. Here, we operate a hybrid electron pump in silicon obtained by coupling a QD to multiple parasitic states, and achi…
Mechanism of porous core electroosmotic pump flow injection system and its application to determination of chromium(VI) in waste-water.
1999
An electroosmotic pump flow injection system is introduced in this paper. According to electroosmotic theory, the pump's properties were described. A large flow range (mul min(-1)-ml min(-1)), moderate carrier pressure (0.15 MPa), reduced performance voltage (500 V) and stable flow rate (RSD3.0% in 4 h) are the main properties of the pump. NH(4)OH (0.35 mM) was used as carrier for improving the pump's flow stability. The electroosmotic efficiency of the pump's medium, porous core, can be recovered and regenerated. A sandwich zone was used for sample and reagent introduction in order to adapt to the pump performance. Flow injection-spectrophotometry was employed for the determination of Cr(V…
Electrostrictive limit in the detection of weak stimulated Raman signals in gases
1997
0377-0486; It is shown experimentally that, in stimulated Raman spectroscopy, electrostriction induced by the pump laser gives rise to a non-resonant signal detected on the probe laser. This phenomenon limits the detectivity of the experiment. A qualitative interpretation is given. (C) 1997 by John Wiley & Sons, Ltd.
DSC: software tool for simulation-based design of control strategies applied to wastewater treatment plants.
2011
This paper presents a computer tool called DSC (Simulation based Controllers Design) that enables an easy design of control systems and strategies applied to wastewater treatment plants. Although the control systems are developed and evaluated by simulation, this tool aims to facilitate the direct implementation of the designed control system to the PC of the full-scale WWTP (wastewater treatment plants). The designed control system can be programmed in a dedicated control application and can be connected to either the simulation software or the SCADA of the plant. To this end, the developed DSC incorporates an OPC server (OLE for process control) which facilitates an open-standard communic…
Analysis of Thermal Comfort Conditions and Actual Energy Efficiency for Different Heating Systems in Test Buildings
2015
The aim of this study is detailed analysis of long-term monitoring data on thermal comfort conditions and energy efficiency in small test buildings equipped with different heating systems. Calculations of PPD index and local thermal discomfort factors, as well as actual energy efficiency ratios for different heat pump systems are provided for the test buildings during three weeks of the heating season. It is shown that the type of heating system has an influence not only on heating energy needs, but also on thermal comfort conditions in the room.