Search results for " Pharmacy"

Vascular Endothelial Growth Factor-Releasing Microspheres Based on Poly(ε-Caprolactone-PEG-ε-Caprolactone)-b-Poly(L-Lactide) Multiblock Copolymers In…

2020

Pancreatic islet transplantation is a promising advanced therapy that has been used to treat patients suffering from diabetes type 1. Traditionally, pancreatic islets are infused via the portal vein, which is subsequently intended to engraft in the liver. Severe immunosuppressive treatments are necessary, however, to prevent rejection of the transplanted islets. Novel approaches therefore have focused on encapsulation of the islets in biomaterial implants which can protect the islets and offer an organ-like environment. Vascularization of the device’s surface is a prerequisite for the survival and proper func- tioning of transplanted pancreatic islets. We are pursuing a prevascularization s…

Vitamin K, and Anaphylactic Shock

1991

A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

2016

The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid st…

Wall collision and drug-carrier detachment in dry powder inhalers: Using DEM to devise a sub-scale model for CFD calculations

2018

Abstract In this work, the Discrete Element Method (DEM) is used to simulate the dispersion process of Active Pharmaceutical Ingredients (API) after a wall collision in dry powders inhaler used for lung delivery. Any fluid dynamic effects are neglected in this analysis at the moment. A three-dimensional model is implemented with one carrier particle (diameter 100 μm) and 882 drug particles (diameter 5 μm). The effect of the impact velocity (varied between 1 and 20 m s−1), angle of impact (between 5° and 90°) and the carrier rotation (±100,000 rad s−1) are investigated for both elastic and sticky walls. The dispersion process shows a preferential area of drug detachment located in the southe…

In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

2019

Idebenone (IDE) is a strong antioxidant that has been proposed for the treatment of skin disorders, including skin ageing. Unfavorable physico-chemical properties make IDE a poor skin permeant where effectiveness could be improved by its loading into suitable delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). In this work, we designed novel IDE-loaded NLC containing tocopheryl acetate (VitE) as a liquid component to obtain a synergic effect between IDE and VitE. The resulting NLC showed small particle sizes (24&ndash

Bronhiālās astmas ārstēšanai izmantojamo medikamentu aprite "Benu aptiekā 2" 2015. gadā

2016

Astma ir izplatīta hroniska elpceļu iekaisuma slimība, kas skar gan bērnus, gan pieaugušos. To raksturo mainīgi un atkārtoti simptomi, atgriezeniska elpceļu obstrukcija un bronhu spazmas. Astmas ārstēšanas mērķis ir iegūt klīnisko kontroli un samazināt nākotnes risku pacientam. Šī darba mērķis ir izpētīt bronhiālās astmas ārstēšanai izmantojamo medikamentu apriti Benu aptiekā 2 Rīgā 2015. gadā un to atbilstību Global Initiative for Asthma (GINA) 2016. gada vadlīnijām. Astmas terapijā ārsti visbiežāk izraksta astmas kontrolējošos medikamentus. Pieprasītākais astmu kontrolējošais medikaments ir inhalējama glikokortikoīda un ilgstošas darbības β2 agonista kombinētais medikaments flutikazons/ s…

Persisten las intoxicaciones por anís estrellado, ¿estamos dando la suficiente información?

2019

Weight Gain Induced by Long-Term Propranolol Treatment

1993

GRP-089 Implementation of a “Medication Safety” Curriculum as Part of the Continuing Education Programme For Pharmacists

2013

Background The ‘action plan for the improvement of medication safety’ issued by the German ministry of health demands a culture of safety awareness. To achieve this goal, an emphasis on medication safety should be placed in the education of health care professionals. In this context the German Society of Hospital Pharmacists (ADKA) has developed a curriculum on medication safety. Purpose A workshop has been developed to improve the awareness of health care professionals regarding medication errors and the risks involved. The tools allow the pharmacist to perform a self-contained failure analysis as a basis for a goal-oriented prevention strategy. Materials and Methods The curriculum consist…

Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying

2020

Abstract The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a new generation of solid dispersions capable to improve both formulation issues and the therapeutic effect of the final dosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, this review describes the field of solid dispersions as well as the formulation strategies available for their production. In part…