Search results for " Primary"
showing 10 items of 453 documents
Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtu…
2003
Disintegrins represent a group of cysteine-rich peptides occurring in Crotalidae and Viperidae snake venoms, and are potent antagonists of several integrin receptors. A novel disintegrin, obtustatin, was isolated from the venom of the Vipera lebetina obtusa viper, and represents the first potent and selective inhibitor of the binding of integrin alpha(1)beta(1) to collagen IV. The primary structure of obtustatin contains 41 amino acids and is the shortest disintegrin described to date. Obtustatin shares the pattern of cysteines of other short disintegrins. However, in contrast to known short disintegrins, the integrin-binding loop of obtustatin is two residues shorter and does not express t…
Sodium Dodecylsulphate Electrophoresis
1994
Sodium dodecylsulphate (SDS) consists of an aliphatic chain of 12 C atoms to which at one end a sulphate residue is bound. It forms complexes with both the polar and non- polar amino acid residues of proteins irrespective of their sizes and shapes, leaving the primary structure uninfluenced. In electrophoresis SDS is used: a) to separate (enzyme) proteins into their monomeric constituents, b) to estimate the molecular mass of unfolded (and reduced) polypeptides, and c) to keep membrane proteins in a solubilized state.
The hedgehog receptor patched is involved in cholesterol transport.
2011
International audience; BACKGROUND: Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors, and one of the most affected Shh signaling steps found in these tumors is the regulation of the signaling receptor Smoothened by the Shh receptor Patched. In the present work, we investigated Patched activity and the mechanism by which Patched inhibits Smoothened. METHODOLOGY/PRINCIPAL FINDINGS: Using the well-known Shh-responding cell line of mouse fibroblasts NIH 3T3, we first observed that enhancement …
Flipped learning e gioia del lavoro ben fatto. Una ricerca con i futuri docenti di scuola primaria e dell'infanzia
2019
La formazione iniziale degli insegnanti richiede un approccio sistemico e modelli formativi per la promozione di interventi finalizzati a favorire negli studenti la consapevolezza del valore dello studio in un quadro orientato a favorire i risultati della formazione così come definiti dai Descrittori di Dublino e a sostenere l'apprendimento responsabile dello studente. La promozione della qualità della didattica universitaria ha come scopo fondamentale quello di garantire agli studenti un apprendimento significativo ed efficace. Initial teacher training requires a systemic approach and training models for the promotion of interventions aimed at encouraging students to evaluate the value of …
Networked Analysis of a Teaching Unit for Primary School Symmetries in the Form of an E-Book
2021
In mathematics education, technology offers many opportunities to enrich curricular contents. Plane symmetries is a topic often skipped by primary teachers. However, it is important and may be worked in attractive ways in dynamic geometry software environments. In any regular classroom there are students with different levels of mathematical attainment, some needing easy tasks while others, particularly mathematically-gifted students, need challenging problems. We present a teaching unit for plane symmetries, adequate for upper primary school grades, implemented in a fully interactive electronic book, with most activities solved in GeoGebra apps. The book allows student to choose which itin…
Cuba and Italy: a comparative study on the determinants of health in a context of limited resources
2012
Italian and Cuban healthcare systems, although operating in very different context, show some of the best evidence in the world in terms of health outcomes. The Cuban model, unique because of an historical-economic-political asset not repeatable, had oriented its development on education and health promotion through a public health approach. The aim of our study is to perform a comparison of the Italian and Cuban healthcare system through the use of health indicators validated at international level in order to identify best practices. Cuba provides health care to all residents focusing strongly on primary care and health promotion and obtains similar results to Italy despite the limited av…
Children's exploration of the concepts of home and belonging: Capturing views from five European countries.
2021
Understanding one's sense of belonging is a central part of identity formation and self-awareness; feeling safe somewhere, with specific people is identified as a basic human need. This paper explores the ideas of children from three age groups in five different European as they discussed the concepts of ‘home’ and ‘belonging’. Findings showed that the children's ideas could be organised into six interrelated aspects: Spatiality, Materiality, Multiplicity, Social Relations, Affect, and Dislocation. Whilst there were differences in the ways that the children conceptualised home across the classes, even the youngest children were able to describe their ideas using metaphors and abstract conce…
Analysis of the Multi-Application Small Light-Water Reactor (MASLWR) Design Natural Circulation Phenomena
2011
Progettazione, narrazione e analisi di pratiche didattiche di genere nel primo ciclo dell'istruzione
2017
The research contribution is part of the PRIN “Success training, inclusion and social cohesion: innovative strategies, ICT and valuation models”, coordinated by G. Domenici at national level, which ended on 28th February 2016. Within the Research unit of Palermo different assumptions have been made, including that of school failure in the first cycle which would be diminished if teachers had implemented a more careful teaching to different ways of learning of male and female pupils. Intervention refers to the process of construction, implementation, narration and analysis of thirty gender teaching practices. The first research goal has been that of producing and validating tools to provide …
La formazione degli insegnanti e le strategie per promuovere la scuola inclusiva
2020
L’educazione inclusiva per divenire una realtà tangibile nel processo educativo della scuola odierna necessita di azioni concrete e di un monitoraggio costante. La misurazione della qualità dell’inclusione rappresenta uno dei fattori fondamentali del suo sviluppo, ma sicuramente l’elemento chiave è la classe docenti, i fautori principali e primari dell’educazione inclusiva. I docenti possono realizzare l’inclusive education se opportunamente formati e se vengono offerti loro validi strumenti di autovalutazione. Formare gli insegnanti a promuovere l’inclusione direttamente nei contesti in cui operano e in relazione ai loro studenti, vuol dire garantire a ogni persona il successo formativo e …