Search results for " Program"
showing 10 items of 3075 documents
Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) seminar.
2012
Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster a…
STRUMENTI E METODI PER INTEGRARE GLI ASPETTI AMBIENTALI NELLA MANUTENZIONE DEL PATRIMONIO ARCHITETTONICO
2022
La corretta e costante applicazione della manutenzione può assumere un ruolo chiave per garantire la qualità del patrimonio costruito e il soddisfacimento delle più recenti classi di requisiti ambientali. A tal fine, è necessario che le strategie che guidano la programmazione delle attività di manutenzione siano modellate sulle caratteristiche del manufatto in esame. In Italia una larga parte degli edifici risulta edificata prima del 1946 e, molti di questi seppur non strettamente tutelati dalla legge, possono presentare rilevanti caratteri morfologici o costruttivi che vanno opportunamente conservati. La manutenzione, condotta in un’ottica sistemica e multiscalare, comprendendo interventi …
Ancestral Reconstruction and Investigations of Genomic Recombination on some Pentapetalae Chloroplasts
2019
Abstract In this article, we propose a semi-automated method to rebuild genome ancestors of chloroplasts by taking into account gene duplication. Two methods have been used in order to achieve this work: a naked eye investigation using homemade scripts, whose results are considered as a basis of knowledge, and a dynamic programming based approach similar to Needleman-Wunsch. The latter fundamentally uses the Gestalt pattern matching method of sequence matcher to evaluate the occurrences probability of each gene in the last common ancestor of two given genomes. The two approaches have been applied on chloroplastic genomes from Apiales, Asterales, and Fabids orders, the latter belonging to Pe…
Programmi di clemenza e azione risarcitoria: convivenza possibile?
2014
This work stems from the European Directive on antitrust damages actions and enquires on the need to preserve the effectiveness of antitrust public and private enforcement within the framework of the relationship between the leniency programmes and actions for damages. As is well known, the leniency programmes allow companies involved in an agreement prohibited by competition law to cooperate with competent Antitrust Authority in order to disclose such an infringement and obtain the immunity or a reduction from fines. This generates the need to preserve the secrecy of leniency statements in order to not deter companies from using such a programme. The Directive provides, inter alia, that na…
L'Autorità garante della concorrenza e del mercato ei prgrammi di clemenza
2010
A distanza di tre anni dall'introduzione dei programmi di clemenza nella legge antitrust italiana, si impone una riflessione sui problemi aperti dalla loro adozione e applicazione. Il contributo li esamina, comparando il sistema italiano con quello comunitario e con gli altri sistemi vigenti nell'ambito dell'ECN. Evidenzia, quindi, alcuni aspetti critici della disciplina italiana, relativi all'accesso dei terzi alle dichiarazioni confessorie e alla documentazione allegata.
Antitumoural Properties of Benzannelated Seven -Membered 5-fluorouracil Derivatives and Related Open Analogues. Molecular Markers for Apoptosis and C…
2005
Attention is increasingly being focussed on the cell cycle and apoptosis as potential targets for therapeutic intervention in cancer. We prepared a series of bioisosteric benzannelated seven-membered 5-FU O,N-acetals to test them against the MCF-7 human breast cancer cell line. Benzo-fused seven-membered O,O-acetals or their acyclic analogues led to the expected 5-FU O,N-acetals (or aminals), in addition to six- and 14-membered aminal structures and acyclic compounds. All the cyclic aminals provoked a G0/G1-phase cell cycle arrest, whereas Ftorafur, a known prodrug of 5-FU, and 1-[2-(2-hydroxymethyl-4-nitrophenoxy)-1-methoxyethyl]-5-fluorouracil (11) induced an S-phase cell cycle arrest. Al…
A Tool for Predicting the Dynamic Response of Biotrickling Filters for VOC Removal
2016
This article presents the development of a MATLAB® computer program to simulate the performance of biotrickling filters. Since these filters behave differently during spraying and nonspraying cycles, the presented simulation tool is built on top of a mathematical description of each situation. The resulting variable-structure model is then used as the basis for simulation experiments. The model presented herein represents the first attempt to take into account the variable spraying pattern usually found in industrial installations. Overall, the software is flexible and easy to use, allowing the user to specify the emission concentration pattern, the gas concentration pattern, as well as the…
Life Cycle Assessment of an Ambitious Renovation of a Norwegian Apartment Building to nZEB Standard
2018
Author's accepted manuscript. The upgrading of building infrastructure to modern standards represents a key tool for reducing global energy demand and emissions from buildings. In Norway, building upgrades have been prioritized despite the relatively low carbon intensity of the Norwegian energy mix through various incentive programs and continual improvement in building standards. Prioritizing upgrades is important as up to 90% of the existing Norwegian building stock is expected to remain standing by the year 2050. The overall impact of upgrading buildings is expected to be a net benefit to the environment but this is primarily in operation, and many studies on energy do not include the ma…
Scenario optimization asset and liability modelling for individual investors
2006
We develop a scenario optimization model for asset and liability management of individual investors. The individual has a given level of initial wealth and a target goal to be reached within some time horizon. The individual must determine an asset allocation strategy so that the portfolio growth rate will be sufficient to reach the target. A scenario optimization model is formulated which maximizes the upside potential of the portfolio, with limits on the downside risk. Both upside and downside are measured vis- `a-vis the goal. The stochastic behavior of asset returns is captured through bootstrap simulation, and the simulation is embedded in the model to determine the optimal portfolio. …
Sampling methods for low-frequency electromagnetic imaging
2007
For the detection of hidden objects by low-frequency electromagnetic imaging the linear sampling method works remarkably well despite the fact that the rigorous mathematical justification is still incomplete. In this work, we give an explanation for this good performance by showing that in the low-frequency limit the measurement operator fulfils the assumptions for the fully justified variant of the linear sampling method, the so-called factorization method. We also show how the method has to be modified in the physically relevant case of electromagnetic imaging with divergence-free currents. We present numerical results to illustrate our findings, and to show that similar performance can b…