Search results for " Protocols"
showing 10 items of 761 documents
Lazy consensus for networks with unknown but bounded disturbances
2007
We consider stationary consensus protocols for networks of dynamic agents. The measure of the neighbors' state is affected by Unknown But Bounded disturbances. Here the main contribution is the formulation and solution of what we call the isin-consensus problem, where the states are required to converge in a tube of ray isin asymptotically or in finite time.
Out-of-Band Signaling Scheme for High Speed Wireless LANs
2007
In recent years, the physical layer data rate provided by 802.11 Wireless LANs has dramatically increased thanks to significant advances in the modulation and coding techniques employed. However, previous studies show that the 802.11 MAC operation, namely the distributed coordination function (DCF), represents a limiting factor: the throughput efficiency drops as the channel bit rate increases, and a throughput upper limit does indeed exist when the channel bit rate goes to infinite high. These findings indicate that the performance of the DCF protocol will not be efficiently improved by merely increasing the channel bit rate. This paper shows that the DCF performance may significantly bene…
Visually Perceived Distance Judgments: Tablet-Based Augmented Reality Versus the Real World
2016
Does visually perceived distance differ when objects are viewed in augmented reality (AR), as opposed to the real world? What are the differences? These questions are theoretically interesting, and the answers are important for the development of many tablet- and phone-based AR applications, including mobile AR navigation systems. This article presents a thorough literature review of distance judgment experimental protocols, and results from several areas of perceptual psychology. In addition to distance judgments of real and virtual objects, this section also discusses previous work in measuring the geometry of virtual picture space and considers how this work might be relevant to tablet A…
Implementation and Deployment Evaluation of the DMAMAC Protocol for Wireless Sensor Actuator Networks
2016
Abstract The increased application of wireless technologies including Wireless Sensor Actuator Networks (WSAN) in industry has given rise to a plethora of protocol designs. These designs target metrics ranging from energy efficiency to real-time constraints. Protocol design typically starts with a requirements specification, and continues with analytic and model-based simulation analysis. State-of- the-art network simulators provide extensive physical environment emulation, but still have limitations due to model abstractions. Deployment testing on actual hardware is therefore vital in order to validate implementability and usability in the real environment. The contribution of this article…
The patient-doctor relationship: new insights in light of the current Ministerial recommendations regarding Phase 2 of the COVID-19 pandemic
2020
Following the publication of the italian Ministerial recommendations relating to dentistry in Phase 2 of the coViD-19 pandemic (focusing on operational protocols for all dental staff), we believe that the patient/dentist relationship should increasingly take into account the heightened fears and anxious thoughts of patients. this particularly regards patients who are about to undergo dental work. Moreover, dentists should also pay close attention to recent events, which have determined the new recommendations regarding SarS-coV-2 biocontainment. Furthermore, the authors of this paper consider it appropriate to make suggestions and develop interventionist techniques regarding the interface w…
Automated Synthesis of Application-layer Connectors from Automata-based Specifications
2019
Abstract Ubiquitous and Pervasive Computing, and the Internet of Things, promote dynamic interaction among heterogeneous systems. To achieve this vision, interoperability among heterogeneous systems represents a key enabler, and mediators are often built to solve protocol mismatches. Many approaches propose the synthesis of mediators. Unfortunately, a rigorous characterization of the concept of interoperability is still lacking, hence making hard to assess their applicability and soundness. In this paper, we provide a framework for the synthesis of mediators that allows us to: (i) characterize the conditions for the mediator existence and correctness; and (ii) establish the applicability bo…
Multiple modes of cell death in neuroendocrine tumors induced by artesunate.
2020
Abstract Background The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile. Methods We evaluated the impact of ART on three NET cell lines, BON-1, QGP-1 and NCI-H727 on cellular and molecular levels. Results Our results showed that ART induced endoplasmic reticulum (ER) stress through phosphorylation of eIF2α, which further gave rise to autophagy in all three NET cell lines. Specifically, apoptosis and ferroptosis were also observed in BON-1 cells, which made BON-1 cell line more vulnerable upon ART treatment. The different sens…
Daratumumab for the Treatment of Multiple Myeloma
2018
This mini-review will summarize the present state of development of the CD38 antibody daratumumab for the treatment of multiple myeloma.
Antitumor Effects of a Combined 5-Aza-2′Deoxycytidine and Valproic Acid Treatment on Rhabdomyosarcoma and Medulloblastoma in Ptch Mutant Mice
2009
Abstract Patched (Ptch) heterozygous mice develop medulloblastoma (MB) and rhabdomyosarcoma (RMS) resembling the corresponding human tumors. We have previously shown that epigenetic silencing of the intact Ptch allele contributes to tumor formation in this model. Here, we investigated whether targeting of epigenetic silencing mechanisms could be useful in the treatment of Ptch-associated cancers. A reduction of endogenous DNA methyltransferase1 (Dnmt1) activity significantly reduced tumor incidence in heterozygous Ptch knockout mice. A combined treatment with the Dnmt inhibitor 5-aza-2′deoxycytidine (5-aza-dC) and the histone deacetlyase (HDAC) inhibitor valproic acid (VPA) efficiently prev…
Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010–present)
2021
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.Area covered: This review aims to give an overview of patents published since 2010 by analyzing the patent space and structure features of scaffolds used in those patents. It also discusses the recent clinical developments and provides perspectives on future challenges and directions in this field.Expert opinion: As a key component of the DNA damage response (DDR) pathway, DNA-PK appears to be a viable drug target for anticancer therapy. The clinical investi…