Search results for " Rats"
showing 10 items of 110 documents
Erythropoietin and its lost receptor [8]
2007
The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model.
2015
International audience; To investigate the effect of nitric oxide on tumor development, we established a rat tumor xenograft model in zebrafish embryos. The injected tumor cells formed masses in which nitric oxide production could be detected by the use of the cell-permeant DAF-FM-DA (diaminofluorophore 4-amino-5-methylamino-2'-7'-difluorofluorescein diacetate) and DAR-4M-AM (diaminorhodamine-4M). This method revealed that nitric oxide production could be co-localized with the tumor xenograft in 46% of the embryos. In 85% of these embryos, tumors were vascularized and blood vessels were observed on day 4 post injection. Furthermore, we demonstrated by qRT-PCR that the transplanted glioma ce…
Taste for fat: the 6th taste modality
2016
IF 4.066; International audience
Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food co…
2011
The impact of early exposure to endocrine disruptor mixtures on mammary gland development is poorly known. Here, we identify the effects of a conception to weaning exposure of rats to the phytoestrogen genistein (G) and/or the antiandrogen vinclozolin (V) at 1 mg/kg-d, alone or in association. Using several approaches, we found that G- and GV-exposed rats displayed significantly greater epithelial branching and proliferation, wider terminal end buds than controls at PND35, as well as ductal hyperplasia and periductal fibrosis. Focal branching defects were present in V-exposed rats. An increased ER and AR expression was observed in G- and CV- as compared to V-exposed rats at PND35. Surprisin…
Ventilatory conditioning by self-stimulation in rats: A pilot study
1994
International audience; This article describes an experimental attempt to condition breathing pattern in rats. In this experiment, a freely moving rat was first rewarded by an electrical stimulation of the medial forebrain bundle whenever inspiratory duration (TI) exceeded 300 ms. A bidirectional control was then used: TIs longer than 400 ms were rewarded, and then TIs shorter than 300 ms were rewarded. The frequency of TIs longer than 300 ms increased when this event was rewarded, further increased when TIs above 400 ms were rewarded, and decreased during reversal conditioning (TI < 300 ms). At the beginning of the experiment, stimulation caused increased arousal and motor activity, but af…
Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food co…
2012
The impact of early exposure to endocrine disruptor mixtures on mammary gland development is poorly known. Here, we identify the effects of a conception to weaning exposure of rats to the phytoestrogen genistein (G) and/or the antiandrogen vinclozolin (V) at 1 mg/kg-d, alone or in association. Using several approaches, we found that G- and GV-exposed rats displayed significantly greater epithelial branching and proliferation, wider terminal end buds than controls at PND35, as well as ductal hyperplasia and periductal fibrosis. Focal branching defects were present in V-exposed rats. An increased ER and AR expression was observed in G- and CV- as compared to V-exposed rats at PND35. Surprisin…
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
2017
Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence o…
Acides gras des phospholipides plaquettaires et des lipides plasmatiques chez le rat obése Zucker
1988
AbstractThe purpose of this work was to see whether hyperlipaemia observed in genetically obese Zucker rats (fa/fa) was associated with differences in fatty-acid composition of plasma triacylglycerols, plasma phospholipids and of platelet phospholipids, in comparison with the control lean rats (Fa/-).Results showed that plasma triacylglycerols and phospholipids were increased in obese rats. In triacylglycerols, the amount of saturated and monounsaturated fatty acids was highly increased whereas the amount of the n-6 and n-3 polyunsaturated fatty acids was little modified. In plasma phospholipids, saturated and monounsaturated fatty acids were also increased, as were the n-3 fatty acids (exc…
SULL'IMPIEGO SPERIMENTALE DI UN COLLANTE BIOLOGICO NELLE ANASTOMOSI INTESTINALI NEL RATTO IN ACCRESCIMENTO
1980
The problems that arise in the preparation of the anastomoses of channelicular organs have not found a unique solution. In fact, when it is necessary to proceed to the synthesis of very small gauge hollow organs as in the accreting subjects (infants) the risk of formation of a stenosis is always present despite the various techniques practiced. In recent years several experimental researches have been carried out in order to verify the validity of biological adhesives in intestinal anastomoses in rapidly growing animals. For this purpose we have chosen the rat whose rapidity of somatic growth permits an evaluation in times contained
Patterns matter: continuous Vs intermittent access to ethanol differently affects withdrawal behavioural phenotype and maternal care in female rats.
2014
Modeling voluntary ethanol consumption in female rats is crucial for gaining further insight in gender-related vulnerability to alcohol. Since ethanol effects depend not only on the amount consumed, but also on drinking pattern, this study aimed at assessing the influence of continuous and intermittent ethanol self-administration on peculiar aspects of female behavioural repertoire during withdrawal and relapse. Female rats undergoing a 15-week-long, 20% ethanol continuous or intermittent (3days/week) access, respectively named CARs and IARs, were tested for alcohol intake (gr/kg) and preference. During withdrawal we assessed: novelty and reward preference in novel object exploration and sa…